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Background: It remains clinically important to identify ER positive breast cancers likely to respond to tamoxifen (TAM) and so we aimed to select a group of biomarkers able to predict response. We also assessed whether data from different sample types [tumor microarrays (TMAs) and core biopsies] or tumor sites could be combined for biomarker studies.Methods: A total of 123 endocrine treatment naïv

BACKGROUND: Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a substantial issue in neonatal intensive care units worldwide. Current therapies to prevent or treat GMH-IVH are limited. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, and/or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonatal stud

Summary: Vertebral fractures are independent risk factors for vertebral and nonvertebral fractures. Since vertebral fractures are often missed, the relatively new introduction of vertebral fracture assessment (VFA) for imaging of the lateral spine during DXA-measurement of the spine and hips may contribute to detect vertebral fractures. We advocate performing a VFA in all patients with a recent fr

How will baby fish react to global warming? As most people have been aware of, global warming is just one of many consequences of climate change and increasing CO2-levels in the atmosphere. The oceans are experts at absorbing energy, which makes the ocean temperature rise. In many parts of the world, especially Australia, the sea surface temperatures (SSTs) are increasing rapidly today. This is e

Nitrous oxide (N2O) emissions, which primarily originate from the biological nitrogen removal process, dominate the release of greenhouse gases (GHGs) in wastewater treatment plants (WWTPs). N2O production occurs through dynamic microbial pathways that have a significant impact on the environment compared with other GHG emissions. Reducing these substantial emissions aligns with the objectives of

Den svenska rättsstaten står inför allvarliga prövningar. Det grova våldet till följd av skjutvapen har ökat markant i Sverige, och risken för tredje man att drabbad av skjutningar och detonationer på offentlig plats har ökat. Samtidigt som våldet även blivit mer hänsynslöst och likgiltigt. Antalet brott inom denna kategori ökar, men uppklaringsandelen är låg. En förklaring till den dystra statistThe Swedish rule of law is facing serious challenges. The use of firearms resulting in severe injury has increased significantly in Sweden, and the risk of third parties being affected by shootings and detonations in public places has increased. At the same time, the violence has become more ruthless and indifferent. While this type of violence is increasing, law enforcement agencies are at a loss

Unsafe food consumption is an alarming issue worldwide which is linked to the fatalities of two million people annually. Such unsafe food intertwines with the right to health of consumers in a way that every individual is ubiquitously a consumer at one point in their life and safe food is one of the determinants of the right to health. Hence, the right to safe food and the right to health of consu

Av de 70 000 personerna som blev diagnoserade med cancer i Sverige 2021, fick runt 4000 lungcancer. Lungcancer är vanligen elakartade celler som utgår från lungans slemhinna. Behandling innefattar oftast operation eller strålterapi, ibland i kombination med cellgifter eller immunterapi. Inför strålbehandling gör patienten en röntgenundersökning som ger bilder i tre dimensioner, en så kallad datorPurpose: The purpose of this master thesis was to retrospectively investigate correlation between surface and tumour motion in lung cancer patients, alongside deep learning applications of the results. Additional correlations such as age, tumour volume and anatomical placement of the tumour were also investigated. Materials and Methods: 48 lung cancer patients treated with Stereotactic Body Radia

To fully decarbonise the energy system, electrification is needed as one of the most important strategies for reducing carbon dioxide emissions in Sweden and Europe. The deployment of renewable energy resources plays a central role in electrification and will continue to increase. In January 2024, Svenska Kraftnät published a long-term market analysis with four future scenarios regarding the devel

Utländska direktinvesteringar i EU skapar arbetstillfällen och för med sig kapital samt expertis från hela världen. Utländska direktinvesteringar är dock inte helt utan risk då de även kan ge upphov till hot mot säkerheten eller allmänna ordningen i unionen. I syfte att hantera dessa risker antogs förordning (EU) 2019/452 av den 19 mars 2019 om upprättande av en ram för granskning av utländska dirForeign direct investments into the EU creates jobs and brings in capital and expertise from all over the world. However, foreign direct investments are not without risks as they can also cause threats to public policy or security in the Union. To mitigate these risks, the EU regulation 2019/452 of 19 March 2019 establishing a framework for the screening of foreign direct investments into the Unio

För erhållande av flyktingstatus krävs det att den sökandes skyddsbehov kan hänföras till någon av de skyddsgrundande egenskaperna i flyktingdefinitionen. Om den sökande har en välgrundad fruktan för förföljelse av en annan anledning är hen alltså inte flykting. Då den sökande anför ett skyddsbehov sur place på grund av konversion fokuseras bedömningen på om den sökandes skyddsbehov är hänförligt In order to obtain refugee status, it requires that the applicant's need for protection attributes to one of the grounds of persecution in the refugee definition. Thus, if the refugee has a well-founded fear for other reasons, they are not a refugee. When the applicant states a need for protection sur place, for purposes of religious conversion, the refugee status determination focuses on whet

GABAergic Neurotrasmission – A “cross-talker” between inflammation and neural plasticity in stroke Stroke is a leading cause of disability and no pharmacological treatment is currently available to promote recovery in suffering patients. A major part of research is focusing on finding new biological targets which can be pharmacologically intervened with, providing favorable results in facilitatin

The aim of the project was to develop a methodology for the chromatographic analysis able to identify the key odorants in meaty food products. The approach was based on the analysis of an already in market product and the theoretical background of the meaty flavors sensorially. Firstly, a custom-made flavor was created for the experiments covering as much as possible a broad area of compounds prec

I syfte att ge innehavaren av en patenträttighet möjlighet att snabbt få stopp på ett pågående patentintrång innehåller patentlagen (1967:837) regler om interimistiska vitesförbud mot intrångsgörare. Ett sådant förbud gäller till dess att slutlig dom meddelats eller domstolen beslutat något annat. Detta förfarande är väl använt inom patenträtten, och blir i praktiken ofta ett slutligt avgörande avIn order to provide a patent holder a possibility to quickly stop an ongoing patent infringement, the Swedish Patent act (1967:837) includes provisions on preliminary injunctions. A preliminary injunction is in effect until a final judgement has been given, or the court has decided otherwise. This procedure is well used in patent law, and in practice often becomes the final solution to a legal dis

Rockfalls occur around Sweden every year and the country lacks a national risk evaluation and an adequate regulatory framework for construction related to this natural hazard. The aim of this study is to address this problem by mapping areas under possible threat of rockfalls, considering two fundamental aspects: i) identification of the source areas and ii) estimation of the runout zones. The stu

När grundläggningen för en byggnad ska dimensioneras är snittkrafter och sättningar som kommer att uppstå i konstruktionen av stor betydelse. Det finns därför ett behov av att kunna beräkna dessa krafter och sättningar på ett säkert och relativt enkelt sätt.All buildings need a foundation that supports the structure. Since a layer of soil is most often in between a structure and the bedrock, a soil-structure interaction between the foundation and the soil beneath occurs. This interaction is of great importance when it comes to predicting the sectional forces that will arise in a structure, along with the settlement that occurs. Therefore the need to

Gut microbiota play a central role in metabolism for example in blood glucose homeostasis and appetite regulation. This thesis provides a prospect of using the bacterium Prevotella copri as a probiotic to help maintain a healthy gut microbiota as many evidences points towards probiotics to have a great potential as preventative agents or therapeutics for type 2 diabetes. In the first part of the tAccording to the World Health Organization (WHO) nearly 8.5% of the global population is affected by metabolic diseases such as type 2 diabetes and obesity which are one of the major causes of death and disability worldwide. This causes a huge financial burden on the healthcare system globally. Therefore, there is an urgent need to prevent, delay and treat these diseases and their debilitating com

We live in a busy world, where the demand of ready-to-eat (RTE) salad products has increased rapidly in a relatively short time. Despite of being an easy and fast way to add more vegetables to the daily diet, RTE salads have a serious underlying risk and the amount of vegetable-derived foodborne disease outbreaks has been increasing. The aim of the present study is to protect plants against contam

The importance of sterilization processes has been a major topic in the food manufacturing industry since it preserves the quality and provides longer shelf-life by preventing microbiological recontamination of products. Aseptic packaging is an alternative technique to pack commercially sterile products into containers with a very low recontamination rate, thus, the entire production chain must be

Den europeiska varumärkesrätten är under förändring och nyligen antog Europaparlamentet ett nytt varumärkesdirektiv och en ny varumärkesförordning. En av de frågor som har varit mest omdiskuterad inför förändringarna är huruvida det räcker med användning av ett varumärke i en medlemsstat för att det territoriella kriteriet som är kopplat till bedömningen av verkligt bruk ska anses uppfyllt i artikThe European trademark law is under revision and recently the European Parliament adopted a new Community Trademark Regulation and a new Trademark Directive. One of the most discussed issues concerning the new legislation is weather it is sufficient to use a trademark in one member state to fulfill the requirement of genuine use in Article 15.1 in the Community Trademark Regulation. Previously the