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Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies

OBJECTIVES: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria.METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on

An Update on Research- & Bolar exemptions in the U.S. and Europe: Unsolved questions and new developments in an increasingly important area of law

In October 2017, the EU Commission announced a consultation on supplementary protection certificates (SPCs) and research exemptions, including Bolar-type provisions. The consultation will provide valuable input for the Commission when preparing an evaluation of the current EU legislation, and any future policy proposals on SPCs and patent exemptions, including the assessment of the impact of diffe

Influence of Internal Diffusional Limitations on the Performance of an Immobilized Enzyme in Organic Medium

The influence of mass-transfer limitations on the performance of immobilized a-chymotrypsin operating in acetonitrile medium has been investigated. The enzyme was immobilized by deposition on various porous carrier materials such as celite, polyamides of different particle sizes, controlled-pore glasses, polypropylene or polyacrylamides. When carrying out kinetically controlled peptide synthesis r

Dynamics of omnivorous crayfish in freshwater ecosystems

Popular Abstract in Swedish Det finns över 500 kräftarter i världen och vi hittar dem på alla kontinenter utom Antarktis och Arktis. I Sverige finns två arter, den inhemska flodkräftan och den introducerade signalkräftan. Signalkräftan introducerades till stor del för att ersätta förlusten av flodkräfta i många pestdrabbade vatten i södra Sverige. Att det just blev signalkräftan berodde främst på In this thesis I examine the dynamics of crayfish in streams and lakes. I have studied the influence of abiotic and biotic factors on abundance, growth, trophic position, niche breadth, and recruitment of crayfish, by conducting field studies, an outdoor channel experiment and timeseries analysis. Overall, the results show that abundance of crayfish is mostly affected by the abundance of predatory

Base deficit estimation in umbilical cord blood is influenced by gestational age, choice of fetal fluid compartment, and algorithm for calculation.

Objective: The purpose of this study was to explore the influences of gestational age, the choice of fetal fluid compartment, and the algorithm for calculation on the estimation of the base deficit in umbilical cord arterial blood Lit birth. Study design: From 1995 to 2002, cord arterial blood gases and obstetric data were available for 43,551 newborn infants at 37 + weeks of gestation (cohort 1).

The CD44(+)/CD24(-) phenotype is enriched in basal-like breast tumors

Introduction Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44(+)/CD24(-) phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is unclear whether their presence within a tumor has clinical implications. There is also a large heterogeneity between tumors, illustrated

Galactic Structure Revealed by Space Astrometry

This work demonstrates how the structure of our Galaxy, the Milky Way, can be unveiled with the use of space astrometry. It consists of two parts, of which the first is a brief introduction to the fields of Galactic structure, covering the Galaxy's stellar constituents, how the Galaxy was formed and how it has evolved over time, both chemically and kinematically. Also the workings of space astrome

On the importance of farmland as stopover habitat for migrating birds

Agricultural intensification has led to dramatic population declines among many farmland bird species. Negative effects of intensive farming in terms of decreased local habitat quality or structural simplification of farmland landscapes have reduced both reproductive outcome and winter survival of many species. Studies investigating agricultural effects on migrating birds using farmland as stopove

Group-based Parental Support in Child Health Service. Development and evaluation of a group leadership course for nurses.

The close relationship between young children’s living conditions and their healthlater in life is well documented and a safe and healthy environment during earlychildhood promotes cognitive functions and social development during the wholelifespan. Becoming a parent is a major life transition and it is sometimes described as a stressful and vulnerable time involving changes to lifestyle and routi

Age, sex, and weight at weaning influence organ weight and gastrointestinal development of weanling pigs

The present study was designed to determine the interrelationships between sex, weaning age, and weaning weight on aspects of physiological and gastrointestinal development in pigs. Forty-eight Large White x Landrace pigs were used in a factorial arrangement with the respective factors being: age at weaning ( 14 or 28 days), weight at weaning ( heavy or light), sex ( boar or gilt), and time after

Towards a capability approach to mobility : An analysis of disparities in mobility opportunities among older people

The overall aim of this thesis is to gain a clearer picture of the differences in mobility among the young-old living in Sweden’s large metropolitan regions. This thesis comprises four papers. Paper I explores the inclusion of public transport as an element of mobility among the young-old living in the Stockholm region. Paper II presents an analysis of cycling among older people in the city of Mal

Statistical analysis of coastal morphological data sets over seasonal to decadal time scales

Statistical analysis of long-term morphological data on coastal sedimentary features provides important information on the processes governing these features and their evolution in space and time. In this paper, seasonal, yearly and decadal (i.e. long-term) behavior of coastal morphological features is derived from field data by using both simple and advanced statistical techniques. The sedimentar

BMD, clinical risk factors and their combination for hip fracture prevention

This study examined the effects of the use of clinical risk factors (CRFs) alone, BMD alone or the combination using the FRAXA (R) tool for the detection of women at risk of hip fracture. BMD tests alone selected women at higher risk and a greater number of hip fracture cases were identified compared to the use of CRFs alone. The combined use of CRFs and BMD identified fewer women above a threshol

Beteendeåtaganden vid företagskoncentrationer

Parterna till en företagskoncentration måste ofta ändra den planerade transaktionen för att kommissionen anser att den påtagligt skulle hämma den effektiva konkurrensen inom gemenskapen. Kommissionen ser helst att de berörda företagen erbjuder sig att avyttra en verksamhet för att på så vis på ett permanent sätt upprätthålla eller återställa konkurrensen på marknaden. Denna typ av strukturellt korParties to a merger often need to change their original transaction plan because the commission’s investigation shows that the merger would lead to significant impediments of the effective competition on the common market. The Commission prefers the undertakings to divest such businesses or assets necessary to permanently maintain or restore an effective competition on the common market. However,

I jakten på rättvisa

In northern Uganda, a war between the Lord’s Resistance Army (LRA) and governmnet troops has raged for more than twenty years. In this conflict, the civilian population has been made a target and subjected to mass scale torture, mutilation and murder. Almost two million people have been forced to flee their homes to reside in government protected camps for Internally Displaced Persons. In these ca

Möjligheter att begränsa utsläpp av SOx och NOx inom sjöfartssektorn- en analys av befintliga och framtida styrmedel för en hållbar utveckling.

One of the cleanest ways of transporting goods is at sea. However, the emissions from ships increase and with a wider knowledge about the environmental consequences caused by the emissions, requisite regulations are needed. This thesis deals with air emissions of sulphate (SOx) - and nitrogen oxides (NOx). These emissions cause negative environmental effects both by direct pollution and by forming

Förvaltningsdomstols utredningsansvar vid mål om tvångsvård av barn

The proceeding in Swedish public administrative courts is regulated by the förvaltningsprocesslag (law of administrative proceeding). According to the 8 § in this law the court shall investigate a case by its nature. This paragraph gives the public administrative courts a duty to investigate their cases. The same paragraph declares that when necessary, the court notifies how the investigation shou

Obehörig vinst i svensk rätt

Rättsprincipen obehörig vinst, eller vinstregeln som den också kallas, har jämfört med andra europeiska rättsordningar haft en marginell betydelse i Sverige. Även om principen under en lång period varit föremål för skarp kritik från rättevetenskapligt håll, så har den på senare tid fått förnyad aktualitet då den dykt upp i flertalet rättsfall. I uppsatsen görs därför en översyn av svensk lagstiftnUnjust enrichment has, compared to other European legal systems, played a marginal role in Sweden. The principle of unjust enrichment has for a long time been the subject of pungent criticism in the Swedish jurisprudence. However, its recent comeback in Swedish case law has given the principle renewed importance. This paper examines and analyses Swedish legislation, case law and doctrine in order

Peak Bone Mass, Lifestyle Factors and Birth Weight: A study of 25-year old women

Background: Osteoporosis is a common bone disease, which does not give symptoms until the ultimate outcome, the fragility fracture occurs. Regulation of bone mass is controlled by genetic, environmental and nutritional influences. Peak bone mass, defined as the maximum bone mass accrued, is usually reached by the third decade of life and is an important determinant of future osteoporotic fracture.

Spatio-temporal patterns in vegetation start of season across the island of Ireland using the MERIS Global Vegetation Index

Spring phenophases such as the beginning of leaf unfolding, measured in the Irish gardens of the International Phenological Garden (IPG) network, indicate an earlier spring occurrence hence a longer growing season. However, these measurements are limited to selected species of trees at a few point locations in the southern half of the country. The aim of this study was to develop a methodology, ba