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Introduction Colon cancer is one of the most common forms of cancer world wide, with an incidence of almost 1 million cases anually. Surgery is a prerequisite for cure and the majority of patients are potentially curable at diagnosis. For a surgical resection to be curative the surgeon needs to remove the tumour together with all affected regional lymph nodes. How extensive the mesenteric resecti
Background Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with differentiated thyroid carcinoma (TC) risk, but strong epidemiological evidence is lacking. Methods Three hundred fifty-seven incident TC case patients (n = 300 women and 57 men; mean age at blood collection = 51.5 years) were identified in the EPIC cohort study and matched with 2 (women) or
Target-specific molecular imaging with radiolabeled antibodies has experienced a rapid growth over the past 20 years, and is now an essential tool to provide information on disease presence and extent. Despite all efforts to detect and control prostate cancer at an early stage, a number of men are still progressing to develop incurable metastatic disease. Because of this, development of new method
Background: Amyloidoses are a heterogeneous group of progressive diseases caused by tissue deposition of misfolded proteins. According to the International Classification of Diseases, hereditary amyloidosis is divided into neuropathic and non-neuropathic forms. In Sweden, neuropathic heredofamilial amyloidosis has been identified as familial amyloidotic polyneuropathy (FAP), a fatal disease that i
This thesis presents models and methods for feedback-based resource management for cyber-physical systems. Common for the scenarios considered are severe resource constraints, uncertain and time-varying conditions and the goal of enabling flexibility in systems design rather than restricting it. A brief survey on reservation-based scheduling, an important enabling technology for this thesis, is pr
BACKGROUND: Knowledge regarding characteristics and transmission of Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium and antibiotic resistance in N gonorrhoeae in Guinea-Bissau, West Africa, is entirely lacking. OBJECTIVES: To characterise N gonorrhoeae, C trachomatis and M genitalium samples from Guinea-Bissau and to define bacterial populations, possible transmission chains
Fracture Liaison Services are the best model to prevent secondary fractures. The International Osteoporosis Foundation developed a Best Practice Framework to provide a quality benchmark. After a year of implementation, we confirmed that a single framework with set criteria is able to benchmark services across healthcare systems worldwide. Introduction Despite evidence for the clinical effectivenes
The demand from the society and authority to recycle and take care of remainder products thorough out the entire product life cycle is constantly increasing. The ambition to create an environmentally friendly, cycle adjusted, waste handle with closed material and energy torrents has made it interesting to develop these kinds of processes for the biological waste torrents within the provision indus
The aim of this thesis project was to develop or lay the base for an innovative oat and chickpea based fermented product. From a previous thesis project, Glucanova AB had developed an oat and chickpea base called OatChic®. The goal of this thesis project was to evaluate the effects of fermentation on OatChic® by characterizing prototypes based on the beta-glucan content, phytic acid content, sugar
När personer i ledande ställning inom ett bolag äger stora aktieposter i bolaget brukar det tolkas som en positiv signal på de finansiella marknaderna. Samtidigt är insiders förehavanden strikt reglerade och inom EU sker detta genom marknadsmissbruksförordningen (MAR). Denna uppsats fokuserar på det så kallade handelsförbudet i artikel 19.11 MAR. Handelsförbudet innebär att personer i ledande stälA management of a company with “skin in the game”, meaning insiders owning a considerable amount of stock, is seen as a positive signal on the markets. At the same time, insider dealings is a heavily regulated area, which in the EU is constituted by the Market Abuse Regulation (MAR). The focus of this essay is on the trade prohibition in article 19.11 MAR, which stipulates that persons discharging
Land cover classification is one of the most studied topics in the field of remote sensing, involving the use of data from satellite sensors to analyze and categorize different land surface types. There are numerous satellite products available, each offering different spatial, spectral, and temporal resolutions. Consequently, several methodologies have been developed to efficiently determine land
With an increasing emphasis on sustainability, and the necessity to align with new regulations, companies face the challenge of transforming their business models to incorporate circularity. Many companies today operate according to a linear business model, where products are designed for consummation and disposal. However, to comply with new demands surrounding sustainability, companies will need
Uppsatsen belyser den problematik som omfamnar ensamkommande barns rätt till uppehållstillstånd i Sverige genom synnerligen ömmande omständigheter, särskilt med tanke på lagändringen i december 2023 som gör det svårare för barn att få uppehållstillstånd beviljat. Detta bekräftas även av statistiken som visar att en betydande minskning av beviljade ansökningar skett året efter lagändringen. UtvecklThe essay highlights the issues surrounding unaccompanied minors' right to residence in Sweden under "particularly distressing circumstances," especially in light of the legislative change in december 2023 that makes it more difficult for children to be granted residence permits. This is confirmed by statistics showing a significant decrease in approved applications in the year follo
Förekomst av tumlare och deras bytesfisk spårade med eDNA kring ön Ven i Öresund Tumlaren (Phocoena phocoena) är den enda bofasta valarten i svenska vatten. Tumlaren är hotad och under nivån för god ekologisk status i svenska vatten. Dessa marina däggdjur är svåra att studera på grund av deras höga rörlighet. Passiv akustisk övervakning, exempelvis med en F-POD, som registrerar tumlarnas klickljuThe mobility of harbor porpoise (Phocoena phocoena) makes the small, toothed whale complicated to study, especially regarding their distribution and foraging over a longer timescale. To overcome this, passive acoustic monitoring, which detects their high-frequency echolocation clicks (ranging from 125-140 kHz), offers a way to track their presence with high temporal resolution (measured as detecte
Background Obesity is increasing among patients with inflammatory bowel disease, but bariatric surgery has been rare in this group owing to concerns about worsening the inflammatory bowel disease. The aim of the study was to evaluate inflammatory bowel disease-related outcomes following bariatric surgery. Methods Nationwide cohort of all adult patients in Sweden between 2007 and 2020 with obesity
Introduction: Carbon monoxide (CO) is a leading cause of environmental poisoning in the United States with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and mitochondrial dysfunction. Currently both biomarkers and therapies for CO poisoning are limited and require new approaches. Methods: Rats (~ 300 g) were divided into four grou
Popular science summary Has climate change influenced flowering time of coltsfoot? Phenological events such as the onset of flowering during the spring are among the most sensitive indicators of climate change. Hence, phenological data have recently emerged as effective tools for studying the impact of climate change on species and ecosystems. In this study, I used records from herbaria and pub
Rationale, Aims and Objectives: Colonoscopy, though common, can be uncomfortable, necessitating routine assessment of patient experience per European guidelines. Positive patient experiences are crucial as they influence willingness for repeat procedures. Patient-reported experience measures (PREMs) effectively capture patient perspectives through surveys, empowering patients to influence healthca
Understanding the drivers of diversity and change in regional Neolithization trajectories has emerged as a major theme in World Prehistory with new insights appearing in many parts of the globe. In Northeast Asia, research on Neolithic transition over the past two decades has focused primarily on millet and rice domestication and their role in the rise of farming, social complexity, and early Chin
Background and Aims The prognosis of adult-onset type 1 diabetes (T1D) and prognostic factors are sparsely investigated. This study assessed mortality, major adverse cardiovascular events (MACE), and prognostic factors in adult-onset T1D, particularly focusing on those diagnosed at age ≥40. Methods Participants were people diagnosed with adult-onset T1D (n = 10 184) or type 2 diabetes (T2D, n = 37
