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Impact of neurohormonal blockade on association between body mass index and mortality.

The prognostic impact of body mass index ( BMI) in patients following acute myocardial infarction ( AMI) may be altered by neurohormonal blockade. Methods: The impact of neurohormonal blockade on the association between BMI and mortality was examined in 5548 patients following AMI ( CONSENSUS II), 50% receiving enalapril and 7% beta- blockade, and in 4367 patients with coronary artery disease ( CA

Chemical and physical characterization of emissions from birch wood combustion in a wood stove

The purpose of this study was to characterize the emissions of a large number of chemical compounds emitted from birch wood combustion in a wood stove. Birch wood is widely used as fuel in Swedish household appliances. The fuel load was held constant during six experiments. Particles < 2.5 mum diameter were collected and the size distribution of the particles was measured. The results were compare

Snuff use associated with abdominal obesity in former smokers.

Abstract Aim: To describe the consumption of snuff in a rural male population and to explore associations between snuff use and obesity. Participants and Methods: Tobacco use was explored in 834 men aged 30-75 years old who participated in a cross-sectional population survey in the municipality of Vara (participation rate was 81%). Self-reported questionnaires assessed the habits of smoking and sn

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This thesis is an exploratory, descriptive and comparative study of teachers’ focus and teaching methods in Spanish as a third language (L3) in Sweden. The curriculum of Modern Languages emphasizes communicative competence and the purpose of the study is to examine how this is applied in the teaching of the course Spanish 4 and how the students progress during the course. Five teachers at four Sen

The epidemiology of Graves' disease: Evidence of a genetic and an environmental contribution.

Previous family and twin studies have indicated that Graves' disease has a heritable component. Family studies have also shown that some autoimmune disease cluster in families and genetic studies have been able to show shared susceptibility genes. In the present nation-wide study we describe familial risk for Graves' disease among parents and offspring, singleton siblings, twins and spouses with r

Energy policy and the role of bioenergy in Poland

Poland, as many other countries, has ambitions to increase the use of renewable energy sources. In this paper, we review the current status of bioenergy in Poland and make a critical assessment of the prospects for increasing the share of bioenergy in energy supply, including policy implications. Bioenergy use was about 4% (165PJ) of primary energy use (3900PJ) and 95% of renewable energy use (174

Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis.

BACKGROUND & AIMS: Corticosteroids alone or in conjunction with azathioprine (AZA) is the standard treatment in autoimmune hepatitis (AiH). Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT) as well as thioguanine nucleotide (TGN) and methylthioinosine monophosphate (meTIM

Cross-diagnostic validity of the Nottingham health profile index of distress (NHPD).

BACKGROUND: The Nottingham Health Profile index of Distress (NHPD) has been proposed as a generic undimensional 24-item measure of illness-related distress that is embedded in the Nottingham Health Profile (NHP). Data indicate that the NHPD may have psychometric advantages to the 6-dimensional NHP profile scores. Detailed psychometric evaluations are, however, lacking. Furthermore, to support the

Joint space width of the tibiofemoral and of the patellofemoral joint in chronic knee pain with or without radiographic osteoarthritis: a 2-year follow-up

Objectives: To assess the interval change of the minimal joint space width (MJS) in radiographs of the tibiofemoral (TF) joint and of the patellofemoral (PF) joint with a 2-year follow-up in middle-aged people with longstanding knee pain with or without radiographic osteoarthritis (OA) and to study the precision of the MJS measurements. Design: In the format of a prospective study of early OA the

Intermittent parathyroid hormone (1-34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats

Distraction osteogenesis is used both for leg lengthening and for bone transportation in the treatment of fractures and nonunions. The main problem with this method is that the time until full recovery may be up to a year, partly because of the time needed for the new formed bone to consolidate and become strong enough for weight bearing. We have studied whether intermittent parathyroid hormone (P

Integrating timescales with time-transfer functions: A practical approach for an INTIMATE database

The purpose of the INTIMATE project is to integrate palaeo-climate information from terrestrial, ice and marine records so that the timing of environmental response to climate forcing can be compared in both space and time. One of the key difficulties in doing this is the range of different methods of dating that can be used across different disciplines. For this reason, one of the main outputs of

Development of sensitive immunoassays for free and total human glandular kallikrein 2

Background: Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. Methods: PSA- and hK2-specific monoclonal antibodies were used in solid-phase, two

Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice

Inhibition of dipeptidyl peptidase- 4 ( DPP- 4) is currently being explored as a new approach to the treatment of type 2 diabetes. This concept has emerged from the powerful and rapid action of the enzyme to inactivate glucagon- like peptide-1 ( GLP- 1). However, other bioactive peptides with potential influence of islet function are also substrates of DPP- 4. Whether this inactivation may add to

Echocardiographic and electrocardiographic identification of those children with hypertrophic cardiomyopathy who should be considered at high-risk of dying suddenly

Background., Hypertrophic cardiomyopathy is a common cause of sudden death in children. In this study, we aimed to identify clinical measures for stratification of this risk in childhood. Patients and methods: By means of a retrospective cohort study from six regional centres of paediatric cardiology, we identified 128 patients with hypertrophic cardiomyopathy presenting below 19 years of age, wit

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.

During the initial indolent chronic phase of chronic myeloid leukemia (CML), the t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Ph), is usually the sole cytogenetic anomaly, but as the disease progresses into the accelerated phase (AP), and eventually into aggressive blast crisis (BC), secondary aberrations, mainly unbalanced changes such as +8, i(17q), and +Ph, are frequent. To date,

Omni-kanalshandel för ett ökat konsumentvärde? - En kvantitativ studie om konsumtionsbeteende och kanalval i köpprocessen inom klädesbranschen

Bakgrund: Användning av olika handelskanaler vid köp av ett klädesplagg har ökat de senaste åren. Företag anpassar sig mer efter konsumenters växande behov av tillgänglighet och flexibilitet. Köpprocessen, från behovsupptäckt till köpbeslut, utförs bland annat i fysisk butik, online på bärbara och stationära datorer eller via mobila enheter. Konsumenter har numera blivit vana att oberoende av kontBackground: The use of different purchasing channels when looking for a piece of clothing has increased in recent years. Companies adapt to a greater extent to consumers’ growing need for accessibility and flexibility. The purchase process, from discovering needs to the decision of purchase, could be performed through physical store, online on a laptop and desktop computer, or through a mobile dev

Funktionalitetsdelning med fokus på användbarhet

In a world of multiple devices, ranging from personal computers to mobile phones, from network attached lighting to smart refrigerators, every category of devices has its typical hardware and capabilities. These capabilities are what characterize the device, but it also sets limitations on what it can do. With the assumption that the majority of all devices have some form of network connectivity,

Internetlänkning på upphovsrättens område - En rättsekonomisk analys

Denna uppsats behandlar regleringen rörande hyper- och inlinelänkar till upphovsrättsskyddat material på internet. Uppsatsen analyserar även potentiella samhällsekonomiska konsekvenser av regleringen ur ett rättsekonomiskt perspektiv. Länkar fungerar som ett verktyg för att underlätta navigering på internet. Upphovsrätten skyddar den som skapat ett litterärt eller konstnärligt verk. I Sverige reglThis essay deals with the regulation regarding inline- and hyperlinks to copyright protected material on the Internet. The essay also analyses the potential consequences of the regulation with an economic analysis of law. Links serve as a tool to navigate on the Internet. Copyright protects the author of a literary or artistic work. In Sweden this right is governed by URL. This law has been adapte

Selective Plane Illumination Microscopy Using Non-spreading Airy Beams

Recently a new field of microscopy has emerged, known as selective plane illumination microscopy (SPIM). Using a SPIM setup the sample is illuminated with a thin light sheet from the side. The selective plane illumination overcomes many problems that conventional microscopes have. Conventional microscopes illuminate the sample axially and collects the light only from the focal plane of the microsc