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Background: Family is a crucial social institution in end-of-life care. Family caregivers are encouraged to take on more responsibility at different times during the illness, providing personal and medical care. Unpaid work can be overburdening, with women often spending more time in care work than men. Objectives: This study explored multiple views on the family’s role in end-of-life care from a
Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. The molecular and cellular mechani
Research on personality traits predicting life outcomes has typically been investigated using the Big Five factors and only occasionally their facets. However, recent research suggests that the use of items (reflecting personality nuances) can account for more predictive variance. The aim of the present study was to examine the predictive validity for various life outcomes comparing the hierarchic
Key messages▶ In the United Nations Framework Convention on Climate Change (UNFCCC), loss and damage has emerged as a third key pillar of climate policy, alongside mitigation and adaptation, to address ever-increasing climate impacts in developing countries that are particularly vulnerable to the adverse effect of climate change. ▶ Losses and damages arise when efforts to avoid or minimize climate
BackgroundMalignant hyperthermia (MH) is a rare pharmacogenetic disorder that can lead to a life-threatening reaction during general anaesthesia with triggering agents. Prompt life-saving treatment includes the immediate administration of the antidote dantrolene. This study investigated Swedish healthcare providers' awareness and adherence to guidelines and recommendations with respect to MH and w
Background: Radical cystectomy for urinary bladder cancer is a procedure associated with a high risk of complications, and poor overall survival (OS) due to both patient and tumour factors. Sarcopenia is one such patient factor. We have developed a fully automated artificial intelligence (AI)-based image analysis tool for segmenting skeletal muscle of the torso and calculating the muscle volume. M
Around 20 % of all electrical energy goes to lighting. There is a strong need to make this figure lower. Our research group has for more than a decade worked with the problem how to reduce the energy use for lighting, but at the same time provide better lighting conditions to meet human needs. The work comprises both laboratory studies and field studies. Two different tracks have been used: One th
BACKGROUND: The purpose of the present study was to evaluate the value of discussing rectal cancer patients in a multidisciplinary team (MDT).METHODS: All treated rectal cancer patients (>T1M0) diagnosed in 2006-2008 were included. According to the national guidelines, neoadjuvant (chemo)radiotherapy should be given to all rectal cancer patients. Patients were scored as "discussed" (MDT+) only if
BACKGROUND: Platelet lysate is a readily available source of growth factors, and other mediators, which has been used in a variety of clinical applications. However, the product remains poorly standardized and the present investigation evaluates the composition of platelet lysate obtained from either fresh or stored pathogen-inactivated platelet units.MATERIALS AND METHODS: Platelet pooled units (
As the adverse impacts of hydrological extremes increase in many regions of the world, a better understanding of the drivers of changes in risk and impacts is essential for effective flood and drought risk management and climate adaptation. However, there is currently a lack of comprehensive, empirical data about the processes, interactions, and feedbacks in complex human-water systems leading to
For the past two decades, the ‘Normative Power Approach’ (NPA) has affected both academic and policymaking debates on the European Union (EU) in global politics. Since its publication in the Journal of Common Market Studies in 2002, the Normative Power article has remained one of the highest cited and most influential articles in the study of European integration. Importantly, the NPA is one of th
Generation of food waste (FW) continues to be a global challenge and high on the political agenda. One of the main reasons for its generation is the absence of detailed data on the amount, timing and reasons for created waste. This paper discusses the design, the application and investigates the Internet of Things (IoT) based FW monitoring system to capture waste data during manufacturing in real-
Differential and double-differential distributions of kinematic variables of leptons from decays of top-quark pairs (tt¯) are measured using the full LHC Run 2 data sample collected with the ATLAS detector. The data were collected at a pp collision energy of s = 13 TeV and correspond to an integrated luminosity of 140 fb −1. The measurements use events containing an oppositely charged eμ pair and
Objective: We aimed to test whether region-specific factors, including spatial expression patterns of the tau-encoding gene MAPT and regional levels of amyloid positron emission tomography (PET), enhance connectivity-based modeling of the spatial variability in tau-PET deposition in the Alzheimer disease (AD) spectrum. Methods: We included 685 participants (395 amyloid-positive participants within
Understanding the mechanisms that regulate the dynamics of spatially structured populations (SSP) is a critical challenge for ecologists and conservation managers. Internal population processes such as births and deaths occur at a local level, while external processes such as dispersal take place at an inter-population level. At both levels, density dependence is expected to play a critical role.
Nanocrystalline AlxCoCrFeNi (x = 0, 0.3, 0.6, 1 mol) high-entropy alloys were synthesized by mechanical alloying (MA) and consolidated by spark plasma sintering (SPS). Single-phase face-centered cubic (FCC) structure was achieved with x = 0 and 0.3. Dual-phase body-centered cubic (BCC)/B2 + FCC structure was obtained in x = 0.6 and 1. Complete solid solution was achieved with a significantly reduc
Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorly understood. Here, we investigated the relationship between cardiorespiratory fitness (CRF), epigenetic aging, and prom
Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling. In this report, we conduct an investigation of multiple published fragmentomics methods for WGS, b
