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Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
Background: HIV-related stigma interventions targeting adolescents living with HIV (ALHIV) are limited. When available, most of these interventions operate at a single socioecological level and target a single stigma domain, and participatory design is rare. Objective: This study aimed to explore the psychosocial support intervention needs of ALHIV from the perspectives of adolescents, caregivers,
Disinhibition of the mechanistic target of rapamycin (mTOR) pathway has been observed in patients with loss-of-function variants in the disheveled, Egl-10, and pleckstrin domain-containing protein 5 (DEPDC5), and nitrogen permease regulator-like proteins 2 and 3 (NPRL2, and NPRL3) genes, which encode the components of GTPase activating protein Activity Toward Rags Complex 1 (GATOR1) complex. Evero
Lipid nanoparticles of reversed internal phase structures, such as cubic micellar (I2) structure show good drug loading ability of peptides and proteins as well as some small molecules. Due to their controllable small size and inner morphology, such nanoparticles are suitable for drug delivery using several different administration routes, including intravenous, intramuscular and subcutaneous inje
The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rational design of synthetic ligands. Here we report the high- to ultrahigh-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand-fre
Background Hyperandrogenicity in women is a risk factor for cardiovascular disease and noninsulin-dependent diabetes mellitus (NIDDM). Estradiol alone decreases hyperandrogenicity and have beneficial effects on glucose metabolism and plasma lipids in postmenopausal women with type 2 diabetes. Objectives To analyse effects on glucose homeostasis and plasma lipids by 2 mg estradiol and 1 mg noreth
Purpose Although there is evidence for interaction between epidermal growth factor receptor ( EGFR) and estrogen receptor ( ER), it is still not clear how this affects response to endocrine therapies like tamoxifen. Here we assess the relationship between EGFR expression and tamoxifen response, with a new quantitative technology. Patients and Methods A tissue microarray was constructed from breast
Purpose: This trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group compares the use of high-dose therapy (HDT) as part of primary treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus etoposide followed by involved-field (IF) radiotherapy in a randomized, multicenter, phase III study. Patients and Methods: Three hundred twelve patients with "aggressive"
Objective: Hairdressers have an increased risk for airway symptoms especially when using hairbleaching powder containing persulfate. To minimize exposure, dust-free bleaching powder (DFP) has been made available. We studied the effects of regular powder (RP) or DFP on the airway symptoms of hairdressers with hair-bleaching associated rhinitis. Methods: Twelve hairdressers each performed three hair
Objectives: The aims of this study were to quantify salivary concentrations of bisphenol A (BPA) and to assess if presence of dental composite fillings is associated with higher BPA levels in saliva. Materials and methods: Twenty individuals with six or more tooth surfaces filled with polymer-based dental materials (composite group) and 20 individuals without any polymer-based materials (control g
Background:Expression of the chemokine CXCL14 has previously been shown to be elevated in the tumour stroma of, for example, prostate and breast cancer. Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. However, the prognostic significance of compartment-specific expression of CXCL14 has not been studied.Methods:CXCL14 mRNA expression
In the Western world, consumption of soft drinks has increased the last three decades and is partly responsible for the epidemic-like increase in obesity. Soft drinks, originally sweetened by sucrose, are now sweetened by other caloric sweeteners, such as fructose. In this study, we investigated the short-term effect of sucrose, glucose or fructose solutions on food intake and body weight in rats,
PURPOSE: Human epidermal growth factor receptor 2 (HER2) gene amplification or protein overexpression (HER2 positivity) defines a clinically challenging subgroup of patients with breast cancer (BC) with variable prognosis and response to therapy. We aimed to investigate the heterogeneous biologic appearance and clinical behavior of HER2-positive tumors using molecular profiling. PATIENTS AND METHO
This study focuses on the hygroscopic properties of submicrometer aerosol particles emitted from two small-scale district heating combustion plants (1 and 1.5 MW) burning two types of biomass fuels (moist forest residue and pellets). The hygroscopic particle diameter growth factor (Gf) was measured when taken from a dehydrated to a humidified state for particle diameters between 30 350 nm (dry siz
Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles gene
Macroscopic phase separation in covalent sodium polyacrylate (PA) networks following the absorption of cetyltrimethylammonium bromide/chloride (CTAB/C) from aqueous solutions is studied experimentally and theoretically. The gels are shown to consist of a solvent-swollen polyelectrolyte network (core), surrounded by a dense surface phase (skin) of polyion/surfactant complexes. The effect of core sw
Internationella dataöverföringar stödjer den globala ekonomin, underlättar internationellt samarbete och främjar ekonomisk expansion. Denna ökade produktivitet innehåller dock risker, nämligen stora risker för kränkningar av den personliga integriteten. I en tid som domineras av tekniska framsteg har regeringar, inom EU och i tredjeländer, potential att överträda individers integritet på en nära gInternational data transfers serve to support the global economy, facilitating international collaboration and economic expansion. However this increased productivity comes at a cost, namely amplified personal data privacy and security risks. In an era dominated by rapid technological advancements, the clandestine actions of intelligence agencies have the potential to infringe upon the privacy and
Despite the issue of greywater management gaining more importance around the world, espe-cially in developing countries, it still remains a challenge in non-sewered areas of South Afri-ca. For a semi-arid country, reusing greywater on a household level has great potential as an alternative water source if done properly. On a household level, the popular repurposing of greywater is for irrigation
1809 antogs en ny regeringsform i Sverige. En nyhet i denna var att den ålade kungen att skydda var och ens rätt till fri religionsutövning, vilket på ytan verkar innebära att religionsfrihet infördes. Samtidigt fanns det i kyrkolagen och missgärningsbalken regler som innebar att svenska medborgare var förbjudna att konvertera från den luthersk-evangeliska kristendomen. Det till synes paradoxala fSweden adopted a new constitution in 1809. It included an article that obligated the king to protect each and everyone’s right to freely practice their religion. This seems like an introduction of religious freedom into Swedish law. However, general law prohibited Swedish citizens from deviating from lutheranian christianity. This thesis focuses on the seemingly contradictory relationship between
Ståndssamhället var den enskilt viktigaste aspekten av det politiska livet i Sverige under 1600- och 1700-talet. I grunden baserad på religiös övertygelse nyttjades ståndssamhället för att kategorisera människor juridiskt och ge dem deras roll i samhället. Adeln, prästerna, borgarna och bönderna presenteras tillsammans med deras privilegier och deras utveckling och successiva förändring. UppsatsenThe community of estates was the most important aspect of the political sphere in Sweden during the 17th and 18th century. It was based on religious beliefs and was used to categorize peoples in a legal way and give them their purpose in society. The aristocracy, the priests, the bourgeois and the peasants are being presented together with their privileges and their development and gradual reforma
