Filetype
The number of approved antiangiogenic drugs is constantly growing and emphasizes the need for predictive biomarkers. The aim of this study was to analyze the predictive value of epidermal growth factor-like domain 7 (EGFL7) and microRNA-126 (miR126) to first-line chemotherapy combined with bevacizumab, in patients with metastatic colorectal cancer (mCRC). A total of 158 patients from two different
The aim of this essay is to examine which help a group of women with eating disorders had from thier treatment in daycare in 2004. The aim is to examine how the women have experienced this treatment and how they live today. The central questions are: what was their life situation like before the treatment, what was their experience of the treatment, how could the treatment have been better and how
One of the biggest question in physics is to investigate the early universe or big bang. 10 µs after big bang, there existed a phase of transition called QGP (Quark Gluon Plasma). In this phase of transition quarks and gluon were free from each other. In normal life neutron and proton consist of three quarks with exchanging gluons. To simulate QGP scientists has built the large accelerator at CERN
Neurofilament light chain (NfL) is a promising biomarker of axonal injury across acute and chronic neurodegeneration, which can improve drug discovery and disease monitoring models. Traditional in vivo animal models cannot fully mimic human pathophysiology of neurodegenerative diseases (NDDs), but in vitro models based on human cells solve this problem, reducing the time and cost of drug testing.
Populärvetenskaplig sammanfattning: Sen den industriella revolutionen har koldioxidhalten i atmosfären nästan fördubblats, från 280 ppm till 360 ppm. Detta har skapat stora diskussioner om hur vårt klimat kommer att påverkas. Koldioxid (CO2) är en växthusgas och med detta menas att den absorberar inkommande energi och på så sätt värmer upp vår jord. I denna studie har fokusen lagts på hur vegetatiIncreasing levels of CO2 in the atmosphere may substantially increase net primary productivity (NPP) and thereby increase carbon sequestration by terrestrial ecosystems. Realistic Free Air Carbon Enrichment (FACE) experiments tend to show a NPP enhancement of about 25% if CO2 is elevated by 200 ppm. In this study two generalized vegetation models, the Lund-Postsdam-Jena dynamic generalized vegetat
The influence of amino acid sequence and structural context on the backbone dynamics of EF-hand calcium-binding loops was investigated using 15N spin relaxation measurements on the calcium-free state of the calbindin D(9k) mutant (A14D+A15Δ+P20Δ+N21G+P43M), in which the N-terminal pseudo- EF-hand loop, characteristic of S100 proteins, was engineered so as to conform with the C-terminal consensus E
Background: Analysis of sialic acid (SA) metabolites in cerebrospinal fluid (CSF) is important for clinical diagnosis. In the present study, a high-performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) method for free sialic acid (FSA) and total sialic acid (TSA) in human CSF was validated. Methods: The method utilized a simple sample-preparation procedure of protein precipitatio
Non-exhaust wear emissions from disc brakes affect the air quality in cities throughout the world. These emissions come from the wear of the contact surfaces of both the pads and disc. The tribological and emissions performance of disc brakes strongly depend on the contact surface characteristics of the pads and discs. The surfaces of conventional pads are scorched by heating it to several hundred
The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to
In workplaces, a lot of knowledge is lost when colleagues change positions. What was once obvious to one person can be incomprehensible to the next. This problem has been encountered by Probation Labs Sweden AB with their biochemical instrument, Labbot. Labbot facilitates researchers in automating their protein analysis. It works like a multi-tool where users can perform one or several tasks in a
The aim with this bachelor thesis is to to create an understanding for how people who primary do not define themselves as men experience the community in digital networks that is separatist for them, as well as examine what significance separatism has for people's perceived sense of community. The informants’ experiences of being a part of digital feminist communities that are free from men, a
Den svenska missbruks- och narkotikamodellen bygger på en restriktiv straffrättslig kontroll med ett narkotikafritt samhälle som mål. Trots detta har Sverige idag högst narkotikarelaterad dödlighet i Europa. Portugal använder istället en modell där skademinimering är centralt och förvärv och innehav avsett för eget bruk samt eget bruk är avkriminaliserat. I dagsläget verkar också Norge ta in på et
Title: Climate Change as Experience - A Study on Climate- and Sustainability Communication in Museums Public perception on climate- and sustainability issues is shaped by how they are presented in media and by other communicative actors - like museums. This thesis explores how museum activities can increase public engagement and awareness on climate change and sustainability. The research has bee
The exponential-6 (exp-6) potential is an intermolecular pair potential that is widely used to model fluids at high densities. The path from molecular interaction to equation of state (EOS) for a gas is not straightforward however. Monte Carlo methods and molecular dynamics give accurate results but are too slow for demanding applications like detonation modelling or numerical simulations of react
Krinoidéer, eller sjöliljor, är en klass echinodermer som kan spåras tillbaka till mitten av ordovicium. Dessa växtlika marina invertebrater är antingen bottensittande eller frisimmande och representeras idag av omkring 600 arter, men gruppen var mycket större historiskt med över 6000 kända fossila arter. Patologiska eller missbildade krinoidéer är relativt vanligt förekommande i det fossila arkiv
Phase separation arises from the substitution of Y in Zr70-xAl12.5Fe17.5Yx (x = 0–25 at.%) metallic glasses (MGs), resulting in the formation of nano-amorphous domains within a glassy matrix. The glasses with x ≥ 10 show a typical liquid phase separation-induced two-glassy phase (Zr-rich and Y-rich) morphology with droplet-like microstructures (nano-amorphous domains). The size of the domains incr
The ST14A cell line was previously derived from embryonic day 14 rat striatal primordia by retroviral transduction of the temperature-sensitive SV40 large T antigen. We showed that cell division and expression of nestin persists at 33°C, the permissive temperature, whereas cell division ceases, nestin expression decreases, and MAP2 expression increases at the nonpermissive temperature of 39°C. In
Soundwalking has its roots as a meditative practice, engaged with ecological concerns. Its origin in R. Murray Schafer's work imbibes it with longing for environments free of industrial sound, and Pauline Oliveros' sound-walking practice seeks the subtle emerging from the silence. Although these progenitors of what we call soundwalking offer us a wonderful palette of listening and walking practice
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common among children. AML is characterized by aberrant proliferation of myeloid blasts in the bone marrow and impaired normal hematopoiesis. Despite the introduction of new drugs and allogeneic bone marrow transplantation, patients have poor overall survival rate with relapse as the major challeng
The supramolecular structures resulting from the complexation between the neutral-cationic block copolymer poly(ethylene oxide)- block-poly(2-(trimethylammonium)ethyl methacrylate iodide) (PEO 114- b-PTMAEMAI 95) and the bile salt sodium deoxycholate (NaDC) were investigated by dynamic light scattering, small-angle X-ray scattering, cryogenic transmission electron microscopy and proton NMR techniq
