Filetype
Background: Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epithelial turnover. TDLUs consist of unique parenchymal entities embedded within a fibroblast-rich lobular stroma. Here, we established and characterized a new human breast lobular fi
Most avian migrants alternate flight bouts, characterized by high metabolic rates, with stopovers, periods of fuel replenishment through hyperphagia. High-energy metabolism and excessive calorie intake shift the balance between damaging prooxidants and antioxidants toward the former. Hence, migration likely affects the oxidative balance of birds. Migratory flight indeed appears to cause oxidative
ABSTRACT: Based on the methylation status of 5 single CpG sites, a novel epigenetic classification of chronic lymphocytic leukemia (CLL) was recently proposed, classifying CLL patients into 3 clinico-biological subgroups with different outcome, termed memory like CLL (m-CLL), naïve like CLL (n-CLL), and a third intermediate CLL subgroup (i-CLL). While m-CLL and n-CLL patients at large corresponded
Phosphorylation is a protein post-translational modification (PTM) that plays an important role in cell signaling, cell differentiation, and metabolism. The hyper phosphorylated forms of certain proteins have been appointed as biomarkers for neurodegenerative diseases, and phosphorylation-related mutations are important for detecting cancer pathways. Due to the low abundance of phosphorylated prot
Background: Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts. This initially provides essential mechanical support to the heart, but eventually compromises function. Osteopontin is associated with fibrosis; however, the underlying signaling m
Lesions in the gene encoding steroid 21-hydroxylase result in congenital adrenal hyperplasia, with impaired secretion of cortisol and aldosterone from the adrenal cortex and overproduction of androgens. A limited number of mutations account for the majority of mutated alleles, but additional rare mutations are responsible for the symptoms in some patients. A total of 11 missense mutations has prev
Protandry, the earlier arrival of males at the breeding grounds relative to females, is common in migratory birds. However, due to difficulties in following individual birds on migration, we still lack knowledge about the spatiotemporal origin of protandry during the annual cycle, impeding our understanding of the proximate drivers of this phenomenon. Here, we use full annual cycle tracking data o
Purpose: This paper is based on a study of six similar buildings built in Gothenburg, Sweden, in 1971, which were in urgent need of renovation. A life cycle profit analysis shows how four competing concepts were evaluated to find a financially viable renovation concept; additionally, the environmental impacts of these renovation concepts using a life cycle assessment are presented. Design/methodol
Background: It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma. Objective: We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status. Methods: We
Migration can influence host–parasite dynamics in animals by increasing exposure to parasites, by reducing the energy available for immune defense, or by culling of infected individuals. These mechanisms have been demonstrated in several comparative analyses; however, few studies have investigated whether conspecific variation in migration distance may also be related to infection risk. Here, we a
Context: Autonomic nervous system activation mediates the increase in whole-body glucoseuptake in response to electroacupuncture but the mechanisms are largely unknown.Objective: To identify the molecular mechanisms underlying electroacupuncture-inducedglucose uptake in skeletal muscle in insulin-resistant overweight/obese women with andwithout polycystic ovary syndrome (PCOS).Design/Participants:
Aktiebolaget är en mycket framgångsrik företagsform för storskaliga och riskfyllda projekt. En egenskap som anses betydelsefull för denna egenskap är aktiebolagets vinstsyfte. Idag finns aktiebolag som ekonomiskt och i fråga om politiskt inflytane kan mäta sig med stater. Detta innebär att de kan ha stor påveran exempelvis på människors tillgång till mänskliga rättigheter. I denna kontext uppmanasThe limited liability company is a form of business associaton that has advantages that makes it attractive for large and risky business entreprises. One characteristic that is viewed as importand for this quality is that the business purpose is increased shareholder value. Today, limited liability companies exists that rival nation states on scale and political impact. As a consequence they can a
Wind energy is one of the fastest growing renewable energies in Sweden. To support this growth, it is essential to give stakeholders, such as investors, municipalities and policy planers, access to high accuracy and high-resolution wind speed data. Essential components for an accurate wind energy potential prediction are the average long-term wind speed and the probability of occurrence of wind
För att uppnå nationella klimat- och miljömål måste den förnybara elproduktionen i Sverige öka inom de närmaste decennierna. Det svenska elcertifikatsystemet är ett marknadsbaserat finansiellt stödsystem med målet att skapa incitament till en ökad förnybar elproduktion. Uppsatsen syftar till att förmedla en överblick av elcertifikatsystemet som är reglerat genom lagen (2011:1200) om elcertifikat. In order to achieve the national climate and environmental objectives, the renewable energy production in Sweden must increase within the next few decades. The Swedish green certificate system (Sw: elcertifikatsystemet) is a market-based financial support system aimed at creating incentives for increased renewable energy production. The purpose of this thesis is to present an overview of the elect
This thesis investigates the climate impact of a newly constructed residential complex in Oceanhamnen, Helsingborg, through an extended life cycle assessment (LCA) covering both building and non-building elements such as road infrastructure, inner courtyards, external installations, that area often overlooked in conventional assessments. The aim is to develop a replicable method to quantify the gl
Mitt kandidatarbete handlar om att representera den elektromagnetiska fälttensorn med matematiska objekt som kallas spinorer, bland annat genom att undersöka hur de transformeras när man byter referenssystem. Den här texten ska försöka förklara vad något av det där betyder, och sedan varför det är intressant för teoretiska fysiker. Vi börjar med transformationer. I våran vardag är vi vana med attThis thesis presents a way of representing electric and magnetic fields directly as linear combinations of products of components of Weyl spinors, without using a four-potential. First it is shown that when Lorentz transforming the spinors, these fields transform according to the tensor transformation of the electromagnetic fields. Then, by explicitly expressing the spinors in terms of a four-mome
The increasing global demand for sustainable energy has sparked interest in combining renewable technologies to leverage their synergies. This thesis presents a pre-feasibility study of a combined offshore wind and wave energy farm located off the coast of Galicia, Spain. In collaboration with Wavepiston, a Danish developer of wave energy converters (WECs), the study evaluates the integration of t
Lake Victoria is Africa’s largest freshwater lake by area shared by three countries: Uganda, Kenya, and Tanzania. The lake supports the economic development of the region through transport and fishing as well as recreational and tourism activities in the three countries. The main ports on the lake are Kisumu, Mwanza, Bukoba, Entebbe, Portbell, and Jinja served by several train ferry services for b
När EU-kommissionens direktiv Corporate Sustainability Due Diligence Directive (CSDDD) röstades igenom i juli 2024 förändrades spelplanen för företag verksamma inom den Europeiska unionen (EU). CSDDD omvandlar det tidigare frivilliga ansvaret att leva upp till Corporate Social Responsibility (CSR) till att bli juridiskt bindande regler. Företag som omfattas av CSDDD är skyldiga att utföra tillbörlWhen the European Commission’s Corporate Sustainability Due Diligence Directive (CSDDD) was voted through in July 2024, the playing field for companies operating within the European Union (EU) changed. The CSDDD transforms the previously voluntary responsibility to adhere to Corporate Social Responsibility (CSR) into legally binding regulations. Companies subject to the CSDDD are required to perfo
För att möjliggöra omställningen från fossila kolväten har bioolja identifierats som ett viktigt verktyg. Bioolja refererar till ämnen med liknande egenskaper som traditionellt petroleum, men som produceras genom kontrollerad förbränning (pyrolys) av jord- och skogsbruksavfall. Bioolja har stor potential, eftersom dess kemisk-fysikaliska likhet till de fossila kolväten som redan används som bränslAn important stepping stone in transitioning from a fossil-fuel based transportation system is the production of bio-fuels such as bio-oils. For bio-oils to be commercially viable, catalytic upgrading via hydrodeoxygenation is required, typically using Ni-Mo oxide or sulfide catalysts. To optimise such processes, a thorough understanding of the catalyst is required. Spark discharge generation (SDG
