Filetype
BACKGROUND: Effector functions of IgG antibodies (Abs) are regulated by their Fc N-glycosylation pattern. IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity of inflammatory (auto)immune disorders and have also been linked to the protection against viral infection and discussed in the context of vaccine-induced protection. In contrast, sialylated IgG Ab
Vårt övergripande forskningsmål är att hitta nya sätt att behandla patienter med metastaserande bröstcancer. Även om stora framsteg i hur vi behandlar bröstcancerpatienter har gjorts under de senaste decennierna så får många patienter fortfarande återfall och metastaserande bröstcancer är fortfarande en obotlig sjukdom. Genom att identifiera signalvägar som är aktiva i metastaser och studera rikta
Microsoft Word - Eligibility form - new version Eligibility form This eligibility form is compulsory to fill out for any exchange student who wishes to apply for courses with prerequisites at the Lund University School of Economics and Management (LUSEM) and the Faculty of Science, or courses in Engineering at the Faculty of Engineering (LTH). Required information: Name: __________________________
https://www.science.lu.se/sites/science.lu.se/files/2025-03/Eligibility_Form_LUSEM_LTH_N_2025.pdf - 2026-07-16
The MAX4 ring is intended to be the future user facility at MAXlab. The high-brilliance 3 GeV storage ring, equipped with small gap, short period superconducting undulators, demonstrates a high mean brilliance over a wide photon energy spectrum. The ring itself is defined from the routine operation of the small gap insertion devices, which is reflected in the small aperture of the ring magnets. Th
HEIMDAL will be a multi length scale neutron scattering instrument for the study of structures covering almost nine orders of magnitude from 0.01 nm to 50 mm. The instrument is accepted for construction at the European Spallation Source (ESS) and features a variable resolution thermal neutron powder diffractometer (TNPD), combined with small angle neutron scattering (SANS) and neutron imaging (NI)
Background: The development of factor (F) VIII neutralizing alloantibodies (inhibitors) is a major complication of treatment with FVIII concentrates in hemophilia A and the etiology is still poorly understood. The low-affinity Fc gamma receptors (Fc gamma R), which are expressed on immune cells, provide an important link between cellular and humoral immunity by interacting with IgG subtypes. Genet
As global warming is proceeding due to rising greenhouse gas concentrations, the Earth system moves towards climate states that challenge adaptation. Past Earth system states are offering possible modelling systems for the global warming of the coming decades. These include the climate of the mid-Pliocene (∼ 3 Ma), the last interglacial (∼ 129-116 ka) and the mid-Holocene (∼ 6 ka). The simulations
A complete reliability study of the high-frequency characteristics for nMOSFETs on InGaAs channel with Al2O3/HfO2 gate dielectric is presented. DC gate voltage stress causes an increase in the transconductance frequency dispersion. Stress induced border traps degrade the maximum DC-transconductance, but do not react at high frequencies. The main degradation characteristics of the high-frequency me
Here we unravel the structural features of human IgM and IgA that govern their interaction with the human Fc alpha/mu receptor (hFc alpha/mu R). Ligand polymerization status was crucial for the interaction, because hFc alpha/mu R binding did not occur with monomeric Ab of either class. hFc alpha/mu R bound IgM with an affinity in the nanomolar range, whereas the affinity for dimeric IgA (dIgA) was
In solid mechanics, linear structures often exhibit (local) nonlinear behavior when close to failure. For instance, the elastic deformation of a structure becomes plastic after being deformed beyond recovery. To properly assess such problems in a real-life application, we need fast and multi-query evaluations of coupled linear and nonlinear structural systems, whose approximations are not straight
Vertical graphene (VG) is a remarkable electrode material for supercapacitors due to its large specific area, open channel structures, and numerous exposed edges with high electrochemical activity. However, flexible supercapacitors with high rate performance based on VG have yet to be investigated. Here, we report flexible supercapacitors based on VG, carbon fabric (CF) current collector, and H2SO
Herpes simplex virus (HSV) induces a receptor on infected cells that is able to bind the Fc part of immunoglobulin G (IgG). We have examined some basic physicochemical and binding properties of the Fc receptor induced on HSV-1 infected green monkey kidney (GMK) cells in its interaction with rabbit IgG. Fixation of HSV-1 infected cells with glutaraldehyde, formaldehyde, acetone or ethanol did not i
The interaction between living groups A, C and G streptococci and IgG Fc was studied using human IgG, IgG Fc and IgG Fc-intermediate (Fci) fragments, chemically modified human IgG and fragment D of staphylococcal protein A (SPA). Diethylpyrocarbonate modification of His or N-acetylimidazole modification of Tyr of human IgG resulted in the loss of its capacity to inhibit the binding of radiolabelle
Lancefield extracts of 19 types of group A streptococci as well as one group C and one group G strain were examined for agglutination of human red cells coated with various anti-Rh antibodies. Fourteen extracts agglutinated one or more of the coated cell samples, while five did not. The agglutination was inhibited by Fc but not by Fab fragments of human IgG. After mouse passages, three of the non-
Insectivore classification has been one of the most controversial problems in mammalian systematics. Evolutionary relationships among the six extant families, Talpidae (moles), Soricidae (shrews), Erinaceidae (hedgehogs), Tenrecidae (tenrecs), Chryosochloridae (golden moles), and Solenodontidae (solenodons), have remained uncertain based on morphological data. Animals classified within the order L
The properties of embedded V2-clauses in Mainland Scandinavian, as opposed to non-V2 clauses, have been a topic of much debate recently. This paper defends the view that all V2 clauses have illocutionary force, which for a declarative clause means that it is asserted. First clauses embedded under the predicate types identified by Hooper & Thompson (1973) are discussed, and it is shown that the
