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Platelets express Toll-like receptor 4 (TLR4), and this has been shown to be responsible for the thrombocytopenia induced by lipopolysaccharide (LPS) administration in vivo. We studied the role of LPS in mediating platelet phagocytosis by THP-1 cells in vitro by flow cytometry. Opsonization of platelets with an IgG monoclonal (W6/32) antibody or with IgG autoantibody-positive sera from patients wi

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Object Shift and Event-Related Brain Potentials Mikael Rolla, Merle Hornea, Magnus Lindgrenb Department of Linguistics and Phoneticsa, Department of Psychologyb, Lund University mikael.roll@ling.lu.se 1. Introduction SWEDISH pronominal objects can either precede or follow a sentence adverb, as shown in example (1). In (1a), the pronominal object den ’it’ precedes the sentence adverb inte ’not’, wh

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_gpdb/Roll_Horne_Lindgren_CNS2007.pdf - 2026-07-20

The sports industry is one of the most challenging and constantly evolving industries, yet simultaneously, the smaller and medium-sized clubs face a severe challenge of competing against the biggest and best-known brands in the world. The sports literature is limited to marketing and studying global mega-brands; this thesis addresses the gap in strategic management literature concerning both sport

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Popular Abstract in Swedish Systemisk skleros (SSc) är en relativt ovanlig reumatologisk sjukdom som kan engagera många av kroppens organ. Sjukdomen kallas ibland också för sklerodermi. Typiskt för sjukdomen är att huden omvandlas till fibros och blir hård och stram över olika delar av kroppen. Typiskt för sjukdomen är också att drabbade patienter har försämrad funktion i sina blodkärl, framförallSystemic sclerosis (SSc) is a systemic rheumatic disease with significant mortality and morbidity. Different estimations of disease prevalence and incidence have been presented from various parts of the world. While lung involvement is a common cause of SSc-related death, a majority of SSc patients suffer from symptoms originating in the gastrointestinal (GI) tract. By combining data from a popu

The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. However, their respective roles in allergic diseases, such as rhinitis, are unclear.