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Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography
Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal
Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by
Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn
4521_Ornis_Omslag 211 Ornis Svecica 12 (2002) Korta rapporter Short communications Om den smalnäbbade sim- snäppans Phalaropus lobatus häckning på jordbruksmark HANS NYSTRÖM Adjan de Jong (2002) rapporterade att han somma- ren 2001 hittade ett bo av smalnäbbad simsnäppa i Ammarnäsdeltat, Sorsele kommun. Det skedde i samband med en inventering av häckande fåglar på jordbruksmark, knuten till ”Lands
https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-1282002nystromsimsnappa.pdf - 2026-05-02
30 maj 2026 19:00 till 22:00 | Utställning, Övrigt 30 May 2026Time slots: at 19:00, at 20:00, at 21:00 (max. 15 people per session)Registration: Please register directly with the artists using the following registration form.“R9K Tuned” is a collaborative cross-disciplinary project by Jonatan Bergsman and Oda Haugerud situated between experimental music and fine arts. An artistic investigation exp
https://www.lu.se/evenemang/r9k-tuned-oda-haugerud-jonatan-bergsman - 2026-05-02
18 mars 2026 18:00 till 21:00 | Konsert, Övrigt "Dream Protocol" merges live performance with immersive sound and video installation, exploring automatism, improvisation, dreams, and the subconscious. Handwritten scores serve as a starting point, translated into sound and visual compositions that integrate grand piano, flute, vocals, electronics, and dream-inspired textual material. Music is compo
https://www.lu.se/evenemang/harmony-automatism-eva-siden-irene-gellein - 2026-05-02
Suicide in children and young adults is a leading cause of premature mortality, and there is a need to develop a more profound understanding of the factors that contribute to these deaths. This study is part of the nationwide Retrospective Investigation of Health Care Utilization in Individuals who died by Suicide in Sweden 2015, conducted at Lund University, Sweden. The aim was to examine symptomSuicide in children and young adults is a leading cause of premature mortality, and there is a need to develop a more profound understanding of the factors that contribute to these deaths. This study is part of the nationwide Retrospective Investigation of Health Care Utilization in Individuals who died by Suicide in Sweden 2015, conducted at Lund University, Sweden. The aim was to examine symptom
Infobroschyr_2016.ppt På våra ins9tu9oner arbetar vi ak9vt med jämställdhetsfrågor. Vi anser a4 det är självklart a4 alla ska behandlas lika på vår ins9tu9on. I de4a informa9onsblad ges informa9on om vårt arbete med dessa frågor samt informa9on om könsrelaterade och sexuella trakasserier. Vill du veta mer om jämställdhet och likabehandling? På följande webbplatser hi4ar du jämställdhetsrelaterad i
https://www.geologi.lu.se/sites/geologi.lu.se/files/infobroschyr_2016_ac.pdf - 2026-05-02
