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FYHR A. & AKSELSSON R. (2012) European Journal of Cancer Care Characteristics of medication errors with parenteral cytotoxic drugs Errors involving cytotoxic drugs have the potential of being fatal and should therefore be prevented. The objective of this article is to identify the characteristics of medication errors involving parenteral cytotoxic drugs in Sweden. A total of 60 cases reported
This study was undertaken to characterize the water-soluble polysaccharides isolated from an herbal tea, the leaves of L. lucidus Turcz. HPLC analysis showed that L. lucidus polysaccharides (LLPs) were mainly composed of galactose (50.1 mol %), followed by galacturonic acid (14.2 mol %), accounting for 64.3 mol % of all quantitative nine monosaccharides. Furthermore, we evaluated the systemic immu
Objective To evaluate the specificity of expression patterns of cell-free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcriptionpolymerase chain reaction assays. A total of 409 plasma samples were obtained from 364 different patients with SLE,
Background: The prognostic role of the arterial blood gas tension of carbon dioxide (PaCO2) in severe Chronic Obstructive Pulmonary Disease (COPD) remains unknown. The aim of this study was to estimate the association between PaCO2 and mortality in oxygen-dependent COPD. Methods: National prospective study of patients starting long-term oxygen therapy (LTOT) for COPD in Sweden between October 1, 2
Depending upon its organization, movement variability may reflect poor or flexible control of a motor task. We studied adult age-related differences in the structure of postural variability in manual pointing using the uncontrolled manifold (UCM) method. Participants from 2 age groups (younger: 20-30 years; older: 70-80 years; 12 subjects per group) completed a total of 120 pointing trials to 2 di
In this article, we describe a third-generation amperometric glucose biosensor working under physiological conditions. This glucose biosensor consists of a recently discovered cellobiose dehydrogenase from the ascomycete Corynascus thermophilus (CtCDH) immobilized on different commercially available screen-printed electrodes made of carbon (SPCEs), carboxyl-functionalized single-walled carbon nano
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any
Background: Outcomes for many cancer forms are associated with socioeconomic status (SES). We investigated if SES was associated with management and mortality in men with high risk prostate cancer. Material and methods: A nation-wide population-based cohort in Prostate Cancer Data Base Sweden (PCBaSe), a merged database including data on incident prostate cancer identified in the National Prostate
Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri
Model studies of the subtype B and non-subtype B integrases are still required to compare their susceptibility to antiretroviral drugs, evaluate the significance of resistance mutations and identify the impact of natural polymorphisms on the level of enzymatic reactivity. We have therefore designed the consensus integrase of the HIV-1 subtype A strain circulating in the former Soviet Union territo
A sudden unilateral loss or impairment of vestibular function causes vertigo, dizziness and impaired postural function. In most occasions, everyday activities supported or not by vestibular rehabilitation programs will promote compensation and the symptoms subside. As the compensatory process requires sensory input, matching performed motor activity, both motor learning of exercises and matching t
Ninety-one HIV-infected individuals (61 men and 30 women) were randomized to vaccination either with quadrivalent (Gardasil™) or bivalent (Cervarix™) HPV vaccine. Neutralizing and specific HPV-binding serum antibodies were measured at baseline and 12 months after the first vaccine dose. Presence of neutralizing and binding antibodies had good agreement (average Kappa for HPV types 6, 11, 16, 18, 3
Nucleic acids are well recognized targets for platinum-based anticancer drugs, with RNA and DNA being kinetically comparable. In the case of RNA, previous studies have shown that the reaction between small duplex RNAs (dsRNAs) and monoaquated cisplatin (cis-Pt(NH3)2Cl(OH2)(+), ) can be followed by the metal induced hyperchromicity occurring directly after addition of to e.g. microRNA mimics. In th
3D computational analysis was performed to investigate heat transfer and pressure drop characteristics of flow in SWFET (Smooth Wavy Fin-and-Elliptical Tube) heat exchanger with four new VGs (vortex generators), RTW (rectangular trapezoidal winglet), ARW (angle rectangular winglet), CARW (curved angle rectangular winglet) and WW (Wheeler wishbone). The numerical model was well validated with the a
Background: Weused a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). Objective: To assess CSF BACE1 activity in AD. Design: Case-control and longitudinal follow-up
As part of the LBA-SMOCC (Large-Scale Biosphere-Atmosphere Experiment in Amazonia – Smoke, Aerosols, Clouds, Rainfall, and Climate) 2002 campaign, we studied the emission of carbon monoxide (CO), carbon dioxide (CO2), and aerosol particles from Amazonian deforestation fires using an instrumented aircraft. Emission ratios for aerosol number (CN) relative to CO (ERCN/CO) fell in the range 14–32 cm−3
Summary The leaking of water through roofs is a major problem in many parts of Tunisia. As a part of a collaboration between "École N: ionale d'Ingénieurs de Tunis" (E.N.I.T.) and Lund University, Institute of Science and Technology (L.N.T.H.), Sweden, a measuring method has been developed to compare the watertightness of different roofing membranes. With the method, three roof structues with diff
Popular Abstract in Swedish Reformationens budskap brukar karakteriseras med hjälp av några "allena": Kristus allena, tron allena, nåden allena och Skriften allena. I denna studie undersöks hur Martin Chemnitz (1522-86) behandlar dessa teman och hur han sätter dem i relation till Augustinus teologi. Martin Chemnitz var en av de mest framstående evangeliska teologerna i generationen efter Martin LuAs a co-author of the Formula of Concord, Martin Chemnitz (1522-86) codified the sola scriptura principle of the Reformation, that the prophetic and apostolic Scriptures are the only rule for all Church doctrine. This principle is clearly expressed in Chemnitz' own theological treatises as well, but in his argumentation one is also confronted with an astonishing number of quotations from the Churc
Prostaglandin E1 has earlier been shown to decrease pulmonary platelet trapping (PPT) following shock. This experiment was performed to evaluate a new method to study PPT in vivo, and to study the effect of prostaglandin E1 and a new antiplatelet drug (ticlopidine) on PPT in rabbits after i.v. administration of endotoxin. Following platelet labeling with In-111, the rabbits were placed under a sci
Popular Abstract in Swedish För drygt ett decennium sedan beslutade EU:s dåvarande tolv medlemsstater att upprätta ett gemensamt europeiskt medborgarskap för unionens invånare. Alltsedan dess har det europeiska medborgarskapet varit en omdiskuterad och kontroversiell, men för den breda allmänheten tämligen okänd, innovation i den europeiska integrationen. I Medborgarskap efter nationalstaten ? ettThis thesis is an attempt to formulate a constructive proposal for the ongoing establishment of a post-national European citizenship in the European Union. To the extent that the proposal is post-national, the ambition is to re-conceptualise the idea and ideal of citizenship in a new historical setting. To the extent that the proposal is constructive, the ambition is to develop and employ a method
