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Background: Non-linearities in observed log-ratios of gene expressions, also known as intensity dependent log-ratios, can often be accounted for by global biases in the two channels being compared. Any step in a microarray process may introduce such offsets and in this article we study the biases introduced by the microarray scanner and the image analysis software. Results: By scanning the same sp

OBJECTIVES: Sleep deprivation has experimentally been shown to adversely influence glucose metabolism, endocrine function and sympathovagal balance in young men without known serious disease. We investigated the impact of sleep problems and resting heart rate in a large sample of self-reported, healthy middle-aged men and women on long-term mortality. METHODS: In all 22,444 men and 10,902 women pa

Today's handheld computing devices equipped with novel wireless network technologies can provide their users with features such as mobility, multimedia support and group communication. On the other hand, the administrative effort required to enable all these features increases beyond the level that an ordinary user can manage. Ad hoc networks, being able to quickly organise themselves without user

Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good

Objective To evaluate the specificity of expression patterns of cell-free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcriptionpolymerase chain reaction assays. A total of 409 plasma samples were obtained from 364 different patients with SLE,

Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri

A sudden unilateral loss or impairment of vestibular function causes vertigo, dizziness and impaired postural function. In most occasions, everyday activities supported or not by vestibular rehabilitation programs will promote compensation and the symptoms subside. As the compensatory process requires sensory input, matching performed motor activity, both motor learning of exercises and matching t

As part of the LBA-SMOCC (Large-Scale Biosphere-Atmosphere Experiment in Amazonia – Smoke, Aerosols, Clouds, Rainfall, and Climate) 2002 campaign, we studied the emission of carbon monoxide (CO), carbon dioxide (CO2), and aerosol particles from Amazonian deforestation fires using an instrumented aircraft. Emission ratios for aerosol number (CN) relative to CO (ERCN/CO) fell in the range 14–32 cm−3

Popular Abstract in Swedish Reformationens budskap brukar karakteriseras med hjälp av några "allena": Kristus allena, tron allena, nåden allena och Skriften allena. I denna studie undersöks hur Martin Chemnitz (1522-86) behandlar dessa teman och hur han sätter dem i relation till Augustinus teologi. Martin Chemnitz var en av de mest framstående evangeliska teologerna i generationen efter Martin LuAs a co-author of the Formula of Concord, Martin Chemnitz (1522-86) codified the sola scriptura principle of the Reformation, that the prophetic and apostolic Scriptures are the only rule for all Church doctrine. This principle is clearly expressed in Chemnitz' own theological treatises as well, but in his argumentation one is also confronted with an astonishing number of quotations from the Churc

Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3). H3K27me3 is characteristic of the chromatin at genes involved in developmental regulation in undifferentiated cells. Overexpression of EZH2 has been found in several cancer types such as breast, prostate, melano

Liberalisation and deregulation of public utility sectors has been introduced in several European countries. In 1994 Swedish municipalities were instructed to reorganise waste collection routines by enlarging the number of fractions to be able to reuse waste fractions in an environmental benign way. The public waste sector have to a considerable extent been diversified and deregulated. At the same

Popular Abstract in Swedish Mesenteriell ischemi (nedsatt blodcirkulation till tarm och övriga bukorgan) är vanligt förekommande vid ett flertal olika sjukdomstillstånd som t ex blödnings-, septisk och cirkulatorisk chock. Inte minst är tarmen mycket känslig för nedsättning av blodflödet. Tarmskadan, inkluderande dess barriär(skydds-)funktion sker dels under perioden med nedsatt blodförsörjning meIntestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction

A systematic study of cell membrane morphologies whose structure is governed by cubic symmetries has been performed. It is suggested that they are described by periodic cubic surfaces for which space filling surface foliations given by truncated Fourier series defined by the space groups is used as structural representations. Using this a method is developed which enables a direct ultrastructural

Popular Abstract in Swedish Polymergeler och deras interaktioner med joniska surfaktanter. Olika typer av hydrofoba polymerer och hydrophobmodifierade polymerer tvärbinds kemisk till geler. Dessa geler tillhör gruppen responsiva geler, vilket betyder att gelerna ändrar sin volym under yttre påverkan. Gelernas volymändring studeras vid tillsats av olika joniska surfaktanter, vid tillsats av saltThe response on chemically crosslinked gels and polymer solutions on the addition of ionic surfactants and/or addition of salt at different temperatures have been studied. All polymers studied are water soluble and slightly hydrophobic or hydrophobically modified. Because of their hydrophobicity the polymers have a strong tendency to associate, both with themselves and with surfactants. Another i

Popular Abstract in French Phytoplancton invasif : génétique des populations, phylogéographie, et facteurs facilitant l’invasion par Gonyostomum semen De nos jours, les espèces invasives représentent une importante menace à la biodiversité. Une espèce invasive colonise un nouvel environnement, ou elle était absente, et atteint de forte densité rapidement, diminuant l’abondance ou remplaçant les esnvasive species is a major threat to ecosystems and biodiversity. Invasions by macroorganisms have been intensively studied, but little is known concerning microbial invasions. In aquatic environments, phytoplankton, i.e. autotrophic microbes, have a key role as primary producers. In my thesis, I focused on the population genetic structure and phylogeography of the freshwater raphidophyte Gonyosto

Two separate topics in the area of colloidal chemistry have been investigated by the use of molecular modeling: the structural properties of polyion?macroion complexes and of diblock polyampholyte brushes. The main results were obtained by the use of Monte Carlo simulation in the framework of the primitive model, and in the case of polyampholyte brushes the simulation results were also complemente

BACKGROUND: Of all patients with low back pain, 85% are diagnosed as "non-specific lumbar pain". Lumbar instability has been described as one specific diagnosis which several authors have described as delayed muscular responses, impaired postural control as well as impaired muscular coordination among these patients. This has mostly been measured and evaluated in a laboratory setting. There are fe

This article examines the pathophysiology of lesions caused by focal cerebral ischemia. Ischemia due to middle cerebral artery occlusion encompasses a densely ischemic focus and a less densely ischemic penumbral zone. Cells in the focus are usually doomed unless reperfusion is quickly instituted. In contrast, although the penumbra contains cells "at risk," these may remain viable for at least 4 to

Popular Abstract in Swedish Med ett stokastiskt fält (random field) kan man matematiskt modellera en yta vars struktur och variationer i större eller mindre utsträckning kan beskrivas som slumpmässiga. Ett typexempel är havsytan. Det finns vissa ''regler'' för hur den kan se ut, men det exakta utseendet hos en viss våg uppfattas som slumpmässigt. Reglerna omfattar bland annat medelnivån, huIn this thesis the focus is on crossing points in random fields and the probability distributions of various crossing variables in different applications. The crossing points are generalisations to random fields of points of level crossings by stochastic processes. Only crossing events that occur at distinct points in the parameter space are considered, for example stationary points (zero-crossing

OBJECTIVES: To investigate the effects on serum lipids, plasma fibrinogen, plasma insulin, plasma C-peptide and blood glucose, of smoking cessation after 4 months. To develop a group-based smoking intervention programme in primary health care. SETTING: Twenty health centres in primary health care in southern Sweden. SUBJECTS: Four hundred habitual smokers (> 10 cigarettes per day-1, > 10 years), r