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This study describes the evaluation and characterization of a self-nanoemulsifying drug delivery system (SNEDDS) consisting of a nonionic surfactant (Cremophor RH40), a mixture of long chain mono-, di-, and triacylglycerides (Maisine 35-1 and Sesame oil) and ethanol. Compositions containing 10% (w/w) ethanol, 40%-60% (w/w) lipid content, and 30%-50% (w/w) Cremophor RH40 were identified as pharmace
PRELP (proline, arginine-rich end leucine-rich repeat protein) is an extracellular matrix leucine-rich repeat protein. The amino-terminal region of PRELP differs from that of other leucine-rich repeat proteins in containing a high number of proline and arginine residues. The clustered proline and basic residues are conserved in rat, bovine, and human PRELP. Although the function of PRELP is not ye
BACKGROUND: Simultaneous contact allergies to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA-R) or epoxy resins of the bisphenol F-type and the reactive diluent phenyl glycidyl ether (PGE) have been reported. The reason might be cross-reactivity, exposure to an epoxy resin system with PGE as a component, or contamination by PGE in the epoxy resin. AIMS: To study contamination by PGE,
The part-load behaviour of combined cycle power plants (CCPP) equipped with post-combustion CO2 capture is analyzed. Different CCPP configurations are compared, including single-, dual- or triple-pressure level steam generators. The gas turbine is a single shaft unit using the variable guide vanes and fuel flow to control the load. The 90% CO2 capture is achieved using monoethanolamine (MEA 30%wt)
Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379
Global population projections foresee the biggest increase to occur in Africa with most of the available uncultivated land to ensure food security remaining on the continent. Simultaneously, greenhouse gas emissions are expected to rise due to ongoing land use change, industrialisation, and transport amongst other reasons with Africa becoming a major emitter of greenhouse gases globally. However,
An important component of the carbon cycle is the lateral flow of dissolved organic carbon (DOC) from terrestrial ecosystems to streams and rivers. The fate of this carbon depends very much on the bioavailability of DOC (BDOC), which may determine whether DOC is returned to the atmosphere as CO2 or deposited in sediments. This study focuses on the linkages between stream DOC composition, optical c
Background: The Tau PET ligand 18F-AV1451 has been shown to reliably detect paired helical filaments of tau in Alzheimer's disease, but it is not yet known whether it binds to the tau aggregates present in patients with mutations in the gene (MAPT) coding for the tau protein. Further, no study has yet compared the cerebral retention of 18F -AV1451 with the tau aggregates revealed using neuropathol
The objective was to investigate if diffusing laser fibres can be modelled as conductive heat sources without miscalculating coagulated volumes, and if finite element analysis, disregarding light transport, may be used for three dimensional (3D) treatment planning in interstitial laser thermotherapy (ILT). Temperature distributions and coagulated volumes with a diffusing laser fibre, as compared t
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcripta
Två grundläggande rättsgrundsatser inom civilprocessrätten är principen om jura novit curia och kontradiktionsprincipen. Jura novit curia innebär att domstolen känner lagen och att domstolen ska tillämpa den adekvata rättsregeln på tvisten, oavsett om parterna baserat sin talan på denna eller ej. Kontradiktionsprincipen, som både finns i intern svensk rätt och i EKMR, stadgar att ingen får dömas oTwo fundamental principles in the Swedish procedural code are the principle iura novit curia and the principle of an adversarial procedure. Iura novit curia means that the court knows the law and that the judge is responsible for the application of the relevant legal rules, whether the parties have based their pleadings on these or not. The principle of an adversarial procedure, which exists both
År 1979 införde Sverige ett uttryckligt agaförbud. Stadgandet i 6 kap. 1 § föräldrabalken, (FB) innebär att föräldrar inte får utsätta barn för kroppslig bestraffning eller annan kränkande behandling. Agaförbudet är en markering från lagstiftarens sida om att barn är extra skyddsvärda. Enligt motiven till 6 kap. 1 § FB är det dock oundvikligt att föräldrar erkänns rätten att övervinna fysiskt motsIn year 1979 a ban on corporal punishment was introduced in Swedish law. According to Children and Parents Code (CPC), parents cannot practice any form of physical punishment upon their children. Hence, the ban on corporal punishment can be considered a clear statement declaring that the protection of children is a matter of high relevance in the Swedish society. However, there is an ambiguity in
Det svenska straffrättsliga systemet bygger på att endast fysiska personer kan begå brott och straffas för dessa. För näringsidkare, såväl fysiska som juridiska personer, har det istället införts särskilda sanktioner såsom företagsbot. Någon särskild reglering av företagsbotsprocessen och näringsidkarens processuella rättigheter vid en talan om företagsbot har däremot inte införts. Samtidigt uppstThe Swedish criminal justice system is based on the fact that only physical persons can commit crimes and be punished for them. For traders, both physical and legal persons, special sanctions such as a corporate fine have been introduced. However, no special regulations of neither the corporate fine procedure nor the procedural rights for traders, when pursuing criminal charges of a corporate fine
In 1968 the alternative artist Sture Johannesson was assigned the task of creating a poster for Underground, an exhibition that took place at Lunds Konsthall. The poster named Revolution means revolutionary consciousness! recieved tremendous attention due to its all too clear subversive messages. It seemed as if Johannesson was promoting a psychedelic, sexual and marxist revolution. The official d
I det blomstrande forskningsfältet om planeter och exoplaneter, det vill säga planeter utanför vårat eget Solsystem hittar vi konstant nya planeter och system som alla ger oss pusselbitar till att förstå hur planeter formas och utvecklas. Så för att förstå de observationer vi gör och bedöma hur sannolikt det är att det kan finnas liv på en planet, måste vi förstå alla olika typer av system och hurIn the thriving field of exoplanet research new discoveries are made all the time, and while most of the observed systems can be explained with classical planet formation models - some are much harder to explain. When stars form they are often surrounded by the remaining material of the nebulae they formed from. Some of this remaining material forms into a protoplanetary disk around the protostars
När High Court of Justice avkunnade dom i målet Bell v Tavistock konstaterade domstolen att barn under 16 års ålder som lider av könsdysfori högst troligen inte kan ge ett giltigt samtycke till pubertetsbromsande hormonbehandling eller könskonträr hormonbehandling. Världen fick då ta del av berättelsen om en ung flicka som genomgått identitetsbekräftande vård och sedan ångrat sitt beslut. Denna upWhen the High Court of Justice ruled in Bell v Tavistock that children under the age of 16 suffering from gender dysphoria most likely could not consent to being treated with puberty blockers or cross-sex hormones, the verdict told the story of a young girl who underwent gender-affirming treatment and later came to regret her decision. This essay studied the decision-making capacity of children an
Rätten att få använda straffprocessuella tvångsmedel är viktig och nödvändig för de brottsutredande myndigheterna för att uppnå så effektiv brottsbekämpning som möjligt. Exempel på typiska straffprocessuella tvångsmedel är häktning, anhållande samt husrannsakan, alla innebär en integritetskränkning för den som utsätts för de. När det gäller hemliga tvångsmedel är de att anse som mer integritetskräThe right to use pre-trial coercive measures is important and necessary for the investigating authorities in the objective of achieving the most effective law enforcement possible. Examples of typical criminal coercive measures are detention, arrest and raids, all of which violate the privacy of the victim. Examples of secret coercive measures are secret telemonitoring and secret telephone tapping
I tider av instabilitet och snabba förändringar krävs det av organisationer att snabbt kunna ställa om till nya förutsättningar för att kunna säkra sin överlevnad. Kreativitet har föreslagits vara en viktig komponent för att kunna göra detta möjligt. För att kreativitet ska kunna blomstra på arbetsplatser krävs det att vissa förutsättningar är uppfyllda. I denna studie var syftet att ta reda på omIn times of uncertainty and rapid changes it is crucial for organizations to be able to adjust to new circumstances in order to secure their survival. Creativity has been suggested as an important component in making this possible. In order for creativity to flourish in the workplace certain conditions need to be met. In this study the aim was to find out whether group personality, aggregated indi
