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The Covid-19 pandemic has changed our lives. The first and unexpected lockdown in Italy has seriously upset people daily routine, working organisation, socialisation and interactions with colleagues and relatives. To overcome the physical isolation and collect impressions, the “How are you?” online questionnaire was created and shared as a conversation among friends. Text mining techniques have be
We introduce the concept of a k-dimensional matrix product D of k matrices (Formula presented.) of sizes (Formula presented.) respectively, where (Formula presented.) is equal to (Formula presented.). We provide upper bounds on the time complexity of computing the product and solving related problems of computing witnesses and maximum witnesses of the Boolean version of the product in terms of the
Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the
BACKGROUND: The study aimed to show the relationship between a large number of circulating metabolites and subsequent cardiovascular disease (CVD) and subclinical markers of CVD in the general population. METHODS AND RESULTS: In 2278 individuals free from CVD in the EpiHealth study (aged 45–75 years, mean age 61 years, 50% women), 790 annotated nonxenobiotic metabolites were measured by mass spect
Purpose: This study investigated the use of surface guided radiotherapy (SGRT) in combination with a tomotherapy treatment mode using discrete delivery angles for deep inspiration breath hold (DIBH) treatments of breast cancer (bc). We aimed to assess the feasibility and dosimetric advantages of this approach. Materials and methods: We evaluated camera occlusion in the Radixact treatment system bo
Rationale & Objective: Use of cystatin C in addition to creatinine to estimate glomerular filtration rate (estimated glomerular filtration rate based on cystatin C [eGFRcys] and estimated glomerular filtration rate based on creatinine [eGFRcr], respectively) is increasing. When eGFRcr and eGFRcys are discordant, it is not known which is more accurate, leading to uncertainty in clinical decisio
Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non–muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatmen
Background: To assess whether retrograde cerebral perfusion reduces neurological injury and mortality in patients undergoing surgery for acute type A aortic dissection. Methods: Single-center, retrospective, observational study including all patients undergoing acute type A aortic dissection repair with deep hypothermic circulatory arrest between January 1998 and December 2022 with or without the
Background: In January 2010, the choice reform was instituted in Swedish primary health care establishing free entry for private primary health care providers and enabling patients to choose freely among primary health care centers. The motivation behind the reform was to improve access to primary care and responsiveness to patient expectations. Reform effects on health care utilization have previ
The only way to combat the depletion of resources and climate crisis is to reduceour dependence on fossil fuels. Renewable sources, such as wind and solar energy,are increasingly used to meet our ever-growing energy demands; however, they areintermittent. One promising solution to the power crisis in the world is fuel cells,which, unlike the combustion engine, can operate on renewable fuels such a
OBJECTIVES: Combination chemotherapy regimens have shown promising results in patients with metastatic colorectal cancer. However, only very few studies have studied the effect of palliative chemotherapy in peritoneal carcinomatosis (PC) and no data are present incorporating biological therapies in the treatment of PC in colorectal cancer.METHODS: By means of merging with the regional Eindhoven Ca
There are many definitions of resilience, but in general it refers to the ability of a system, which may be a community, society, or economic system that are exposed to extreme disturbances, persistent stress, or hazards to resist, absorb, accommodate, adapt to, transform and recover from effects of the situation in a timely and efficient manner (PreventionWeb n.d.;). Sustainability is focused on
Since its public release on November 30, 2022, ChatGPT has shown promising potential in diverse healthcare applications despite ethical challenges, privacy issues, and possible biases. The aim of this study was to identify and assess the most influential publications in the field of ChatGPT utility in healthcare using bibliometric analysis. The study employed an advanced search on three databases,
Aim: Accumulated data suggest that routine use of defunctioning stoma in low anterior resection for rectal cancer may cause kidney injury, bowel dysfunction and a higher risk of permanent stomas. We aim to study whether avoidance of a diverting stoma in selected patients is safe and reduces adverse consequences. Methods: SELSA is a multicentre international prospective observational study nesting
Aim: The selective use of defunctioning stomas in anterior resection for rectal cancer hinges on accurately predicting anastomotic leakage. The aim of this study was to develop a prediction model for use in a prospective randomized clinical trial. Method: Colorectal Cancer Database (CRCBaSe) Sweden was used to identify patients who underwent low anterior resection for rectal cancer 2007–2021. Elig
Background A substantial untapped potential for risk reduction may be fulfilled by applying intensive lifestyle interventions targeting the co-existing risky lifestyle factors Smoking, Nutrition (both malnutrition and obesity), risky Alcohol intake, and Physical inactivity (SNAP) before surgery. This trial will compare the effect of combined and individually tailored prehabilitation with standard
PURPOSE: To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association.EXPERIMENTAL DESIGN: Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed
With a fuel consumption of up to 150 tons a day for a containership, fuel cost is the main expense for shippers. To decrease expenses, drag reduction is the most important topic to address. The biggest factor that influence the hydrodynamics of a vessel is marine fouling. A heavily fouled ship can consume an additional 40 % of fuel or more. The process of marine fouling is an extremely diverse and
BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from t
The development and consumption of functional food are increasing. To meet such an increasing demand, vegetable milk extracted from quinoa and fermented with lactic acid bacteria can offer an excellent alternative to fermented dairy milk which has a high nutritive value and is free from lactose, gluten and cholesterol. This research aims at: (a) isolating and identifying the autochthonous microbio
