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Introduction The intensity and duration of childhood cancer treatment may disrupt psychosocial development and thereby cause difficulties in transition into adulthood. The study objective was to assess social outcomes in early adulthood after successful treatment for childhood acute myeloid leukemia (AML), Wilms tumor (WT) and infratentorial astrocytoma (IA). Methods Nordic patients treated for AM
Purpose Primary lung adenocarcinoma remains a deadly disease. Gene expression phenotypes (GEPs) in adenocarcinoma have potential to provide clinically relevant disease stratification for improved prognosis and treatment prediction, given appropriate clinical and methodological validation. Experimental Design 2395 transcriptional adenocarcinoma profiles were assembled from 17 public cohorts and cla
Background: Prognostic factors in patients with localized primary cutaneous malignant melanoma (CMM) are well described. However, prognostic factors for recurrence are less documented. Objectives: The aim of this study was to identify prognostic risk factors for first recurrence in patients with localized stages I-II CMM using population-based data. Methods: This study included 1437 CMM patients r
The mucopolysaccharidoses (MPS) are lysosomal storage disorders that result from defects in the catabolism of glycosaminoglycans. Impaired muscle, bone, and connective tissue are typical clinical features of MPS due to disruption of the extracellular matrix. Markers of MPS disease pathology are needed to determine disease severity and monitor effects of existing and emerging new treatments on dise
The spruce bark beetle Ips typographus is the most damaging pest in European spruce forests and has caused great ecological and economic disturbances in recent years. Although native to Eurasia, I. typographus has been intercepted more than 200 times in North America and could establish there as an exotic pest if it can find suitable host trees. Using in vitro bioassays, we compared the preference
Currently, in the era of big data and 5G communication technology, electromigration has become a serious reliability issue for the miniaturized solder joints used in microelectronic devices. Since the effective charge number (Z*) is considered as the driving force for electromigration, the lack of accurate experimental values for Z* poses severe challenges for the simulation-aided design of electr
Hydroxide ion conducting poly(terphenyl alkylene)s functionalized with piperidine-based quaternary ammonium cations were synthesized via superacid-catalyzed polyhydroxyalkylations. By employing different synthetic strategies, we have systematically varied the structures of the cation and the backbone polymer to study the effects on morphology, stability and hydroxide conductivity. Two monomers wer
The utilisation of biomass instead of fossil resources is an important alternative for the transition into a sustainable society. Biomass, owing to its primary constituents—cellulose, hemicelluloses and lignin—has the potential to replace many products that are produced from fossil resources today, including plastics, textile fibres and fuels. To fully exploit this potential, all of the components
Using an animal model, the thesis explores how the initial ventilation of the lungs, and surfactant therapy, should best be managed after premature birth. Material and measurements: The studies were made in newborn lambs delivered by cesarean section. Spread of exogenous surfactant was analysed by mixing it with technetium-labelled macroaggregated human serum albumin and imaging the radioactivity
Popular Abstract in Swedish Elektrostatiske vekselvirkninger mellem biomolekyler er vigtige, ikke bare i biologiske systemer, men også i flere tekniske sammenhænge. I denne afhandling studereres en række forskellige egenskaber, relevant for særligt proteiner. Således har vi ved hjælp af molekylær simulering undersøgt hvorledes proteiner vekselvirker med protoner, salte, andre peptider og proteinerElectrostatic interactions in bio-molecular systems are important not only in the living cell but also in more technical applications. Using molecular simulation as well as approximate theories the properties of a number of aqueous protein solutions have been studied. This includes interactions with other proteins, protons, charged membranes as well as flexible polyelectrolytes. The focus is on el
Popular Abstract in Swedish I Sverige insjuknar årligen drygt 6000 kvinnor i bröstcancer. Antalet nyinsjuknade kvinnor i sjukdomen stiger något för varje år samtidigt som dödligheten minskar. En av orsaken till den minskade dödligheten är modern medicinsk behandling som idag kompletterar den kirurgiska behandlingen. Sjukdomsförloppet vid bröstcancer är mycket varierande beroende på tumörens utbredBackground: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. In spite of adjuvant treatment with TAM, some patients with h
OBJECTIVE: Nitric oxide (NO) and oxygen free radicals are implicated in the pathophysiology of traumatic brain injury (TBI). Peroxynitrite formation from NO and superoxide contributes to secondary neuronal injury but the neuroprotective effects of nitric oxide synthase (NOS)-inhibitors have been contradictory. This study was undertaken to examine whether PTtic administration of the (NOS)-inhibitor
Popular Abstract in Undetermined All of our present information technology culture with computers, internet, smart-phones, Bluetooth links, 3D-Tv, iPad tablets, programmable washing/cooking machines, car engines, navigation computers, etc. (the list goes on and on) is based on small electrical circuits. The smaller these circuits can be made, the faster and the better microelectronics can perform.Present-day electronics employ circuits of smaller and smaller dimensions, and today the length scales are so small that the laws of physics which rule micro-cosmos, quantum mechanics, become directly important. This thesis reports on theoretical work on electron transport in different nanostructures. We have studied semiconductor quantum wells, layered materials where each layer can be only a few
Popular Abstract in Swedish Modellsystem för metall-DNA interaktioner Med fokus på anticanceraktiva platina(II) komplex Guld är ett mytomspunnet och fascinerande ämne som ger liv. Ett påstående som kanske förvånar, eftersom guld ofta förknippas med vackra smycken och rikedom. Att guld skulle ge liv var dock en förhoppning i Kina på 600-talet f. Kr. Där använde man nämligen metalliskt guld för medReactions of trans-dicyanodichloroaurate(III) trans-dibromodicyanoaurate(III), trans-diamminedichlorogold(III), cis-diammine(aqua)chloroplatinum(II), cis-ammineaqua-(cyclohexylamine)chloroplatinum(II), chloro(terpyridine)platinum(II) and chloro-(diethylenetriaminepalldium(II) with dimethyl sulfide, thionucleosides, thionucleotides and thione- and guanine-containing 17-mer oligonucleotides have bee
Popular Abstract in Swedish Denna avhandling behandlar modellsystem för farmaka som har DNA och RNA som mål i cellen. Framförallt behandlar den hur strukturen hos DNA och RNA påverkas av inbindning av olika substanser, samt hur fort denna inbindning sker. Tre olika typer av farmaka behandlas: 1. Platinaföreningar som länge använts som cytostatika, 2. RNA interferens som främst har utvecklats undDrugs targeting nucleic acids were studied in DNA and RNA model systems. The effects were investigated with respect to structural and thermodynamic influence, kinetics, and biological function. The drugs employed in this thesis were anticancer active platinum(II) complexes, polyamine derivatives, and siRNA. Structural changes were determined by use of chemical probing and circular dichroism (CD),
With the emergence of Green Chemistry, biocatalysis is becoming an important approach in many laboratory and industrial processes. Enzymes catalyse chemical reactions with high regio- and stereoselectivity at mild conditions and, most importantly, are able to form products that are not possible to obtain by conventional synthetic chemistry. Monooxygenases are a fascinating group of enzymes which o
Context: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. Objective: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n
Intensive harvesting of forest residues for energy production may lead to the depletion of organic matter and mineral nutrients in the forest floor. In order to restore nutrient content wood ash has been suggested as a fertiliser. Ectomycorrhizal (EM) fungi arc involved in the nutrient uptake of forest trees and this study investigates the influence of intensive harvesting and wood ash fertilisati
Popular Abstract in Swedish ”Har en galopperande häst vid något tillfälle alla hovarna i luften samtidigt?” Den här till synes enkla frågan är inte helt enkel att svara på eftersom det inte går att avgöra med blotta ögat om så är fallet. För att avgöra om hovarna verkligen är i luften på samma gång behöver vi andra redskap med bättre tidsupplösning än våra ögon. Första gången någon lyckades göra eOne objective of attosecond science is to study electron dynamics in atoms and molecular systems on their natural time scale. This can be done using attosecond light pulses. Attosecond pulses are produced in a process called high-order harmonic generation, in which a short, intense laser pulse interacts with atoms or molecules in a highly nonlinear process, leading to the generation of high-order
This thesis explores the possibility of using advanced device geometries and heterostructure engineering to manipulate, control, and study the electrical and optical properties of semiconductor nanowires. The first part of the thesis investigates the use of different gate-all-around architectures for creating new types of gate-controlled nanowire devices, primarily intended for fundamental studies
