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L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact
Popular Abstract in Swedish Sammanfattning på svenska Den svenska nationella cancerstategin från 2009 understryker patientperspektivet och fokus ligger på själva patientprocessen. Modern bröstcancerbehandling omfattar en mer individualiserad behandling med bröstbevarande kirurgi, diagnostik av portvaktskörteln, ett ökat användande av medicinsk terapi med cellgift, antihormon samt antikroppar i såAbstract Background. The Swedish national cancer strategy programme published in 2009 emphasises the patient perspective and focuses on the patient process. Over the years the different modalities in breast cancer treatment are changing position, making accurate diagnosis and quality assurance in breast pathology even more important than before. Aims. The aim of paper I was to examine overall su
Background. The aim of this study was to determine the relationship between single-nucleotide polymorphisms (SNPs) in MRP2 genes and mycophenolic acid (MPA) pharmacokinetics in renal transplant recipients of the Symphony Pharmacogenomic substudy. Methods. Sixty-six renal transplant recipients of eight Spanish centres were randomized into four branches of immunosuppressive regimen: low dose of cycl
Människohandel för sexuella ändamål är ett komplext fenomen och ett globalt problem som både berör och upprör. Människohandel är gärningar som syftar till ett efterföljande utnyttjande av offret och ett brott där skyddssyftet är personlig frihet och frid. Det är också ett sammansatt problem, det vill säga att det innefattar bland annat brott mot mänskliga rättigheter, organiserad brottslighet, migHuman trafficking for sexual purposes is a complex phenomenon and a global problem that upsets. Human trafficking is an acts aimed to subsequent exploit the victim and a crime which aim the protection of personal liberty and peace. It is also a complex problem, that includes human rights violations, organized crime, migration, gender, poverty and social, economic and political differences between
Den globala klimatförändingen är vår tids största utmaning och det största miljömässiga, sociala och ekonomiska hotet världen över. Genom att använda husdjursgödsel för produktion av förnyelsebar energi i form av biogas kan utsläppen av västhusgaser minskas, samtidigt som lokala resurser utnyttjas på ett hållbart sätt. Norge har som nationellt mål att 30 % av husdjurgödseln ska användas till produClimate change because of increased greenhouse gases in the atmosphere is widely recognized and is our times biggest environmental, social and economical threat worldwide. Converting livestock manure into a renewable energy resource such as biogas contributes to lowering greenhouse gases emissions and takes advantage of local energy resources in a sustainable way. Norway has a national goal to pro
This thesis purpose was to contribute to knowledge which could explain the driving forces behind Corporate Social Responsibility in corporate Sweden and their strategic impact from a management perspective. The method used to archive this research was a qualitative interpretative study conducted by interviews. The thesis is based on descriptive theories of drivers for CSR, concepts of strategy and
There has been much work on classification of malaria infected blood; in resent time, a method using LED-based microscopy has been developed with the goal of reducing time and cost. The education level needed to make such decisions is also reduced using this microscope. This is mainly done to help the developing countries in the fight against malaria and develop these countries competence in the f
Swedish office buildings of the 60’s present at least 27% higher heating demand than from the current standards foreseen. This underlines their need for energy renovation. Meanwhile, office buildings are occupied during daytime, thus internal and solar gains are in phase. Consequently, such buildings could experience overheating problems. A seasonal adaptable envelope, such as a ventilated double
Aims: To evaluate the effects of adding glucagon-like peptide-1 (GLP-1) analogue therapy to insulin on glycated hemoglobin (HbA1c), weight, insulin dosage, treatment satisfaction, and risk of hypoglycaemia. Methods: Type 2 diabetes patients with insulin therapy receiving a GLP-1 analogue at 4 Swedish centers were studied. Hypoglycemia was evaluated using glucometers and patient self-report. The Di
The recipients of blood components, from the first 12 anti-hepatitis C virus (HCV) positive donors identified by blood donor screening, 1985-1991, were traced retrospectively and tested to assess the HCV transmission rate, HCV genotypes and disease severity. Three enzyme-linked immunosorbent assay (ELISA) positive but RIBA-indeterminate and HCV RNA-negative donors did not transmit HCV to their 9 t
On 1 April 2015, the EU milk quotas were abolished after 30 years in force. The purpose of this paper is to assess the Intra-Union trade effects of the reform, using the gravity model of trade. In particular, the aim is to find out whether competitive Member States have started to export more dairy products as compared to the non-competitive Member States following the reform. In order to perfor
Samhället genomgår ett omfattande paradigmskifte för att bekämpa de utmaningar som är förenade med de antropogena utsläppen av koldioxid (CO2) och andra växthusgaser som bidrar till den globala uppvärmningen. Fordonsindustrin som står för en femtedel av de globala utsläppen, varav tre fjärdedelar är kopplade till vägfordon, ser en omvälvande ökning i efterfrågan på icke-fossildrivna fordon så som The societal integration of electric vehicles (EVs) imposes several challenges on the electrical grid, where congestion and overcurrents through related components are of focus for this thesis. Active network management through control systems is one flexible solution to this problem, and in the project Active Network Management for All (ANM4L), a congestion management algorithm utilizing PI contr
Proteiner är kroppens byggstenar och behövs bland annat för att reparera celler, bygga upp vävnader och muskler samt bilda enzymer. Proteinbrist kan leda till försämrad hälsa och därför finns rekommendationer att andelen protein i den dagliga kosten bör utgöra 18 E%. Nedbrytning och upptag av proteiner sker från magsäcken till tunntarmen där bland annat olika enzymer är delaktiga i spjälkningen. TProteins are the building blocks of the body and are needed to repair cells, build tissues and muscles and form enzymes. Protein deficiency can lead to deteriorating health and therefore there are recommendations that the proportion of protein in the daily diet should be 18 E%. Digestion and uptake of proteins takes place from the stomach to the small intestine, where various enzymes are involved.
De utmaningar som dagens och kommande generationer står inför, till följd av klimatförändringarnas konsekvenser, har inga motsvarigheter i historien. Därför utmanas vårt tänkande och agerande från grunden. Som en följd av detta finns en rörelse som försöker påverka politiken och samhället i en mer hållbar riktning: klimataktivisterna. I oktober 2024 friades en klimataktivist av Stockholms tingsrätThe challenges faced by current and future generations as a result of the impacts of climate change are unprecedented. Therefore, our modes of thinking and acting are being fundamentally challenged. As a result, a new climate movement has emerged, calling on politicians to ensure sustainable policies and societies. In October 2024, a climate activist was acquitted by the Stockholm District Court o
Popular Abstract in Swedish Att balansera. Cancer från ett primärvårdsperspektiv. Diagnostik, posttraumatisk stress och vård vid livets slut Denna avhandling belyser cancer från en utgångspunkt som kanske inte handlar om vad man först kommer att tänka på när man hör ordet cancerforskning. Det handlar inte om att “lösa cancerns gåta” eller att hitta nya metoder för behandling eller diagnos. UtgångThis thesis explores cancer from a primary care perspective covering three areas: diagnosis, posttraumatic stress disorder (PTSD), and end-of-life care. We analyzed patient records of every child diagnosed with a malignancy in a defined area. During 12 years 68 children were diagnosed (incidence 14/100,000). For 68% the diagnosis was initiated in primary care. There were 25 children with leukemia
Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, pulmonary function, lower airway symptoms, and cigarette smoking from the general population are lacking. The current study investigates the relationships between CRS and chronic airflow limitation (CAL), lower airway symptoms and COPD in a middle-aged populat
The association between socioeconomic circumstances and incidence of chronic obstructive pulmonary disease (COPD) was investigated in an urban population in Sweden. The study included all 40–89 year-old inhabitants in Malmö, Sweden (N = 117,479) without previous hospitalization due to COPD, who were followed over 14 years for COPD related hospital admissions. The Malmö Preventive Project (MPP) co
Objectives. Despite accumulating research on yoga and its positive impact on both physiological and psychological health, it is still unclear how yoga improves health. Two central components of yoga: yogic breathing and mindfulness, may be important mechanisms by which individuals learn to cope with their daily stressors, and thereby reduce their risk of developing stress-related illness. In this ObjectivesDespite accumulating research on yoga and its positive impact on both physiological and psychological health, it is still unclear how yoga improves health. Two central components of yoga, yogic breathing and mindfulness, may be important mechanisms by which individuals learn to cope with their daily stressors, and thereby reduce their risk of developing stress-related illness. In this st
Background: Benchmarking on an international level might lead to improved outcomes at a national level. The aim of this study was to compare treatment and surgical outcome data from the Swedish National Register for Oesophageal and Gastric Cancer (NREV) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA).Methods: All patients with primary oesophageal or gastric cancer who underwent a resectio
