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Breast cancer. Quality Assurance and Prognosis.

Popular Abstract in Swedish Sammanfattning på svenska Den svenska nationella cancerstategin från 2009 understryker patientperspektivet och fokus ligger på själva patientprocessen. Modern bröstcancerbehandling omfattar en mer individualiserad behandling med bröstbevarande kirurgi, diagnostik av portvaktskörteln, ett ökat användande av medicinsk terapi med cellgift, antihormon samt antikroppar i såAbstract Background. The Swedish national cancer strategy programme published in 2009 emphasises the patient perspective and focuses on the patient process. Over the years the different modalities in breast cancer treatment are changing position, making accurate diagnosis and quality assurance in breast pathology even more important than before. Aims. The aim of paper I was to examine overall su

Preoperative ropivacaine infiltration in breast surgery

Purpose: The aim of the study was to investigate whether preoperative infiltration with ropivacaine in conjunction with breast surgery improves postoperative pain management and attenuates postoperative nausea and vomiting. Method: Prospective, randomised, double-blind study, including 60 healthy women (ASA 1–2) allocated to one of two groups. Thirty patients were given 0.3 ml/kg saline in the o

Lung cancer in systemic lupus erythematosus

Background: Evidence points to a link between systemic lupus erythematosus (SLE) and an increased risk of lung cancer. Our objective was to provide a brief report of the lung cancer cases from an SLE cohort, with respect to demographics, histology, and exposures to smoking and immunosuppressive medications. Methods: Data were obtained from a multi-site international cohort study of over 9500 SLE p

Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis.

BACKGROUND: /st> Previous studies have indicated that autoantibodies may be detected years before the clinical onset of rheumatoid arthritis (RA). Cartilage biomarkers, such as cartilage oligomeric matrix protein (COMP), have not been studied previously in samples collected before the diagnosis of RA. METHODS: /st> Between 1991 and 1996, 30 447 subjects were included in the Malmö Diet Cancer Study

Passive extraction and clean-up of phenoxy acid herbicides in samples from a groundwater plume using hollow fiber supported liquid membranes

Hollow fiber supported liquid membranes were applied for the passive extraction of phenoxy acid herbicides from water samples. Polypropylene hollow fiber membranes (240 mu m i.d., 30 mu m wall thickness, 0.05 mu m pore size, 30 cm length) were impregnated with 2.0% tri-n-octylphosphine oxide (TOPO) in di-n-hexyl ether in the pores of the fiber wall to form a liquid membrane. They were then filled

Metabolic Syndrome Development during Aging with Special Reference to Obesity Without the Metabolic Syndrome

Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materi

Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors

PURPOSE: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors.METHODS: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients

Antimicrobial combination treatment including ciprofloxacin decreased the mortality rate of Pseudomonas aeruginosa bacteraemia : a retrospective cohort study

Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regim

Adjustable valves in normal-pressure hydrocephalus: a retrospective study of 218 patients.

OBJECTIVE: We sought to assess the value of adjusting shunt valve opening pressure, complications, and outcomes with the use of an adjustable shunt valve in the treatment of patients with normal-pressure hydrocephalus (NPH). METHODS: In a single-center retrospective study, 231 adjustable valves (range, 30-200 mm H2O) were the first shunt implantations in 147 patients with idiopathic NPH (INPH) and

Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis (IOTA) group.

Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent meta-analysis concluded that the International Ovarian Tumor Analysis (IOTA) algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. We sought to develop and validate a model to predict the risk of malignancy in ad

Reforming Refugee Protection: What role can a 'Compact' play in the development of future International Refugee Law?

The Global Compact on Refugees, which is to be adopted in the autumn of 2018, represents an aspiration on the part of the international community towards strengthened solidarity with refugees and affected host countries and is the most ambitious instrument of its kind to date. Indeed, the creation of the Refugee Compact is timely, although perhaps also somewhat surprising in an era of rising popul

Method for interfacial energy determination of gold nanoparticles on solid surfaces

The high surface-to-volume ratio of nanoparticles (NPs) makes them an interesting source for scientific research. How interfacial energies interplay between such a small structure and a solid bulk surface, are important because of the versatile applications NPs regard. In this thesis, a convenient and reliable method for interfacial energy determination was investigated. The interfacial energies

Resilience at the sharp end – a description of nurses' capability to create safety

A large part of the hunt for safety within the healthcare domain seems to be about hunting errors and trying to develop barriers to prevent similar errors in the future, learning from errors. People are seen as the liability and they should try harder to be safe. This study focuses on trying to understand how nurses create safety within the work instead of looking at the errors produced, learni

Clinical Aspects on Chimney Stent Graft Technique in Endovascular Repair of the Aorta.

Popular Abstract in Swedish Inledning/introduktion: Öppen rekonstruktion av aorta innebär en påtaglig risk för postoperativa komplikationer och dödlighet, särskilt i den äldre befolkningen och i dem som är mindre lämpliga för en sådan stor operation. Endovaskulär aorta kirurgi förefaller säker, hållbar och effektiv när det finns tillräcklig proximal och distal tätningszon för en stentgraft. FenestIntroduction: Open repair of the aorta carries a high risk for morbidity and mortality especially in the elderly population and in patients unfit for major surgery. Endovascular aortic repair is safe, durable and effective when there is adequate proximal and distal sealing zone for the aortic stent graft. Fenestrated and branched stent grafts have made the repair possible for complex but elective

Legitimering av tvångsvård : Klienter och deras socialsekreterare om LVM

Syftet med denna avhandling har varit att undersöka tvångsvårdens legitimitet. För det ändamålet har jag genomfört, spelat in och transkriberat kvalitativa intervjuer med 80 klienter – som var föremål för LVM-vård våren 2006 – samt deras socialsekreterare när klienterna dels var intagna på LVM-hem och dels vid en uppföljning cirka sex månader efter tvångsvårdens slut. Avhandlingen utgår från fem The aim of this dissertation was to examine the legitimacy and the legitimizing of compulsory care for substance abusers according to LVM. For this purpose I have conducted, recorded and transcribed qualitative interviews with 80 clients – taken into such care in spring 2006 – and their social welfare officers when the clients were in compulsory care and then again about six months after its termi

Influence of MRP2 on MPA pharmacokinetics in renal transplant recipients-results of the Pharmacogenomic Substudy within the Symphony Study

Background. The aim of this study was to determine the relationship between single-nucleotide polymorphisms (SNPs) in MRP2 genes and mycophenolic acid (MPA) pharmacokinetics in renal transplant recipients of the Symphony Pharmacogenomic substudy. Methods. Sixty-six renal transplant recipients of eight Spanish centres were randomized into four branches of immunosuppressive regimen: low dose of cycl

Striatal Glutamate Release in L-DOPA-Induced Dyskinetic Animals

L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact

GIS-baserad metod för etablering av centraliserade biogasanläggningar baserad på husdjursgödsel

Den globala klimatförändingen är vår tids största utmaning och det största miljömässiga, sociala och ekonomiska hotet världen över. Genom att använda husdjursgödsel för produktion av förnyelsebar energi i form av biogas kan utsläppen av västhusgaser minskas, samtidigt som lokala resurser utnyttjas på ett hållbart sätt. Norge har som nationellt mål att 30 % av husdjurgödseln ska användas till produClimate change because of increased greenhouse gases in the atmosphere is widely recognized and is our times biggest environmental, social and economical threat worldwide. Converting livestock manure into a renewable energy resource such as biogas contributes to lowering greenhouse gases emissions and takes advantage of local energy resources in a sustainable way. Norway has a national goal to pro

Hepatitis C virus transmission, 1988-1991, via blood components from donors subsequently found to be anti-HCV-positive

The recipients of blood components, from the first 12 anti-hepatitis C virus (HCV) positive donors identified by blood donor screening, 1985-1991, were traced retrospectively and tested to assess the HCV transmission rate, HCV genotypes and disease severity. Three enzyme-linked immunosorbent assay (ELISA) positive but RIBA-indeterminate and HCV RNA-negative donors did not transmit HCV to their 9 t

Effectiveness of a light-weight ice-vest for body cooling in fire figther´s work

The aim of the present study was to examine the effects of wearing a light-weight ice-vest (1 kg, water) on physiological and subjective responses in fire fighter’s work. The experiments were carried out in a climatic chamber, in a container under extreme radiant heat, and during simulated smoke-diving. In addition, the physical cooling effect of the ice-vest was measured with a thermal mannequin.