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Supported phospholipid bilayers (SPBs) have emerged as important model systems for studies of the natural cell membrane and its components, which are essential for the integrity and function of cells in all living organisms, and also constitute common targets for therapeutic drugs and in disease diagnosis. However, the preferential occurrence of spontaneous SPB formation on silicon-based substrate
In this work, the interfacing of a poly(ethylene glycol) (PEG)-phosphate aqueous two-phase system with hydrophobic interaction chromatography (HIC) for primary recovery of an intracellular protein was evaluated. As a model protein, a recombinant cutinase furnished with a tryptophan-proline (WP) peptide tag was used and produced intracellularly in Escherichia coli (E. coli). E. coli cell homogenate
The experience with radioimmunotherapy in B-cell lymphomas using the rapidly internalizing antibody, anti-CD22 (LL2), is limited. In this study we investigated the efficacy and toxicity of 131I-labelled-LL2 for radioimmunotherapy in patients with B-cell lymphomas that failed one or two cytostatic regimens. Eleven patients were treated with one or repeated cycles of 131I-anti-CD22 antibody, 1330 MB
Most III-V compound semiconductor nanowires seeded by metal particles grow preferentially in a (over bar 1 over bar 1 over bar 1)B direction (B wires) and most commonly with many stacking faults perpendicular to the growth direction. If growth proceeds in an alternate direction, defect-free growth has been observed. We present experimental results for the growth of GaAs nanowires in a previously u
The Women's Health in the Lund Area (WHILA) study invited all women (n=10,766) living in the Lund area of Southern Sweden by 1995, who were born between 1935 and 1945. The health screening program included a postal validated questionnaire concerning medical history, drug treatment, family history of diabetes and hypertension, menopausal status, smoking and alcohol habits, education, household, and
A concept based on the Peroxidase-chip (P-chip), antibody co-immobilization, competitive and enzyme-channeling principle was exploited to develop an integrated flow-through amperometric biosensor for detection of environmental pollutants such as s-triazine herbicides. In this concept, recombinant peroxidase is immobilized on the gold electrode (P-chip) in such a way that direct electron transfer i
We have studied whether calculations of the binding free energy of small ligands to a protein by the MM/GBSA approach (molecular mechanics combined with generalized Born and surface area solvation) can be sped up by including only a restricted number of atoms close to the ligand. If the protein is truncated before the molecular dynamics (MD) simulations, quite large changes are observed for the ca
Background and objectives: Fetal RHD genotyping of cell-free maternal plasma DNA from RhD negative pregnant women can be used to guide targeted antenatal and postnatal anti-D prophylaxis for the prevention of RhD immunization. To assure the quality of clinical testing, we conducted an external quality assessment workshop with the participation of 31 laboratories. Materials and methods: Aliquots of
The purpose of this essay was to analyze the management and steering of the social welfare service. The objective was specifically to examine how the leaders approach their position as managers of the social welfare service, and also how they approach their way of steering. The social welfare service acts under political decisions, but the management interpret and transform these decisions into ac
Title: A qualitative and quantitative analysis of the risk parameter LGD based on the Basel II Framework Seminar date: 27 January 2007 Course: Financial Economy, Master Thesis, 10 poäng (15 ECTS) Author: Helén Dybing Advisor: Hans Byström Key words: LGD, LTV, Risk, Basel II, Estimation model Purpose: The purpose of this thesis is to get a deeper understanding of the risk parameter LGD and try to i
BACKGROUND: Permanent pacemaker implantation (PPM) early after cardiac transplantation has been shown not to predict a worse outcome. However, the requirement for pacing late after transplantation and its prognostic implications are not fully known. We describe the clinical indications, risk factors and long-term outcome in patients who required pacing early and late after transplantation.METHODS:
The general goal of the Swedish drug policy is to create a society free from narcotics. The government aims to reach this goal with a restrictive policy where consumption of narcotics is illegal, which is very uncommon in democratic countries. This policy has in later years been criticized due to the high number of deaths related to drug use in Sweden and little has been done by the government to
Immune checkpoint blockade (ICB) therapy can restore T cell function in tumors, but not all patients benefit, and the mechanisms behind this remain unclear. In this study, we used patient-derived organotypic (PDO) cultures from metastatic melanoma to examine transcriptomic and cellular changes following ex vivo T cell stimulation. Genomic and transcriptomic features were preserved during PDO forma
How Do We Treat the Super-Elderly with Distal Radius Fractures and What is the Outcome? A Register Study in 239 Patients of 80 years or olderLinnea Sara Arvidsson, MD; Ellen Lööf, Bachelor of Medicine; Antonio Abramo, PhD; Magnus Tägil, PhDLund University, Lund, SwedenIntroductionWith a rapidly ageing population, the number of wrist fractures will rise dramatically in the super elderly group. BasiIntroductionWith a rapidly ageing population, the number of wrist fractures will rise dramatically in the super elderly group. Basic knowledge of outcome after fracture in this heterogenic group is absent. Our aim was to use our prospective distal radius fracture register to study the super-elderly patients with distal radius fractures. We hypothesized that the health status of the patient, rather
Postal address Lunds universitet, Box 117, 221 00 Lund Visiting address Naturvetarvägen 16D Telephone 046-222 00 00 Email sara.naurin@fs.lu.se, johanna.mellgren@fs.lu.se Website www.fs.lu.se Research Services Sara Naur in & Johanna Mel lgren Research funding advisors Lund University’s internal management rules for applications to the Knut and Alice Wallenberg Foundation – grants for research proje
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/management_rules_kaw2020.pdf - 2026-05-30
Postal address Lunds universitet, Box 117, 221 00 Lund Visiting address Scheeletorget 1, Medicon Village Telephone 046-222 00 00 Email sara.naurin@fs.lu.se, johanna.mellgren@fs.lu.se Website www.fs.lu.se Research Serv ices Sara Naur in & Johanna Mel lgren Research funding adv isors Lund University’s internal management rules for applications to the Knut and Alice Wallenberg Foundation – grants for
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/managementrules-kaw2021.pdf - 2026-05-30
1 Verksamhetsplan för Socialhögskolan 2018 Antagen av Institutionsstyrelsen 2017-12-13 INLEDNING Denna verksamhetsplan presenterar Socialhögskolans samlade verksamhet utifrån den indelning som görs i budget: grundutbildning, forskarutbildning, forskning och gemensamma verksamheter. Eftersom de huvudsakliga kostnaderna för verksamheten består i personalkostnader och personalen är institutionens vik
https://www.soch.lu.se/internt/sites/soch.lu.se.internt/files/verksamhetsplan_2018.pdf - 2026-05-30
Immobilised 1,3-specific lipase from Rhizopus arrhizus was used as catalyst for the esterification of dl-glycero-3-phosphate and fatty acid or fatty acid vinyl ester in a solvent-free system. With lauric acid vinyl ester as acyl donor, a(w)<0.53 favored the synthesis of lysophosphatidic acid (1-acyl-rac-glycero-3-phosphate, LPA1) and the spontaneous acyl migration of the fatty acid on the molecule
