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Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects.

Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of

Burakumin and Shimazaki Toson's Hakai: Images of Discrimination in Modern Japanese Literature

Popular Abstract in Swedish Shimazaki Toson (1872 - 1943) anses vara Japans främste företrädare för shizenshugi - en japansk form av fransk Naturalisme. Hans debut som romanförfattare skedde 1906 med Hakai - Löftesbrottet. Romanen anses allmänt vara en representant för kokuhaku shosetsu, eller en "bekännelseroman". Denna avhandling påvisar att författaren hade politiska ambitioner att påvisa diskrPublished in 1906, Hakai or The Broken Commandment in English, by Shimazaki Tôson, is generally considered the first novel in the genre of shizenshugi, a Japanese variation of French Naturalisme. Traditionally, the novel has been viewed as an example of kokuhaku shôsetsu, or “confessional novel” in that the protagonist “confesses” his origin as a member of Eta¾an autochtonous and despised minority

Diesel Exhaust Exposure Assessment Among Tunnel Construction Workers—Correlations Between Nitrogen Dioxide, Respirable Elemental Carbon, and Particle Number

Objectives: Occupational exposure to diesel exhaust is common due the widespread use of dieselpowered combustion engines. Diesel exhaust is chemically complex and consists of thousands of compounds present as gases and particulate matter. Both nitrogen dioxide (NO2) and elemental carbon(EC) have been used as markers for diesel exhaust exposure. Currently EC is regarded as the best surrogate of die

Risk Factors for Contra-Lateral Secondary Anterior Cruciate Ligament Injury : A Systematic Review with Meta-Analysis

Background: The risk of sustaining a contra-lateral anterior cruciate ligament (C-ACL) injury after primary unilateral ACL injury is high. C-ACL injury often contributes to a further decline in function and quality of life, including failure to return to sport. There is, however, very limited knowledge about which risk factors that contribute to C-ACL injury. Objective: To systematically review in

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients

Purpose: Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals. Experimental Design: Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate call

Label-free separation of peripheral blood mononuclear cells from whole blood by gradient acoustic focusing

Efficient techniques for separating target cells from undiluted blood are necessary for various diagnostic and research applications. This paper presents acoustic focusing in dense media containing iodixanol to purify peripheral blood mononuclear cells (PBMCs) from whole blood in a label-free and flow-through format. If the blood is laminated or mixed with iodixanol solutions while passing through

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Lisbeth Nilsson Summary presentation Kids Loco I am most thankful to meeting with sensai Junichi Takashio in England 2012 and getting the opportunity to visit Biwako Gakuen in 2014, and returning to Japan in 2017 and 2018. Thanks to these meetings Driving to Learn and the Assessment of Learning Powered mobility use (ALP) became known in Japan. This presentation will show what develops if an infant

Isotope fractionation of zinc in the paddy rice soil-water environment and the role of 2’deoxymugineic acid (DMA) as zincophore under Zn limiting conditions

Non-traditional stable isotope systems are increasingly used to study micronutrient cycling and acquisition in terrestrial ecosystems. We previously proposed for zinc (Zn) a conceptual model linking observed isotope signatures and fractionations to biogeochemical processes occurring in the rice soil environment and we suggested that 2’deoxymugineic acid (DMA) could play an important role for rice

Perceived research needs for Battery and Hydrogen Safety : A Nordic Perspective

Changes in the energy landscape relating both to the ambitions of a green energy transformation as well as increasing global security concerns, have led to increased attention to new energy carriers. These can serve the role of allowing for the electrification of transport and decarbonization of industries as well as to reduce the effects of variation in many sustainable energy sources such as winChanges in the energy landscape relating both to the ambitions of a green energy transformation as well as increasing global security concerns, have led to increased attention to new energy carriers. These can serve the role of allowing for the electrification of transport and decarbonization of industries as well as to reduce the effects of variation in many sustainable energy sources such as win

Diffusive-ballistic heat transport in thin films using energy conserving dissipative particle dynamics

Diffusive-ballistic heat transport in thin films was simulated using energy conserving dissipative particle dynamics (DPDe). The solution domain was considered to be two-dimensional with DPD particles distributed uniformly under constant temperature boundary conditions at the top and bottom walls and periodic boundaries at the side walls. The effects of phonon mean free path were incorporated by i

Graded effects of oxygen and respiratory inhibitors on cell metabolism and spontaneous contractions in smooth muscle of the rat portal vein

The basis for the hypoxic relaxation of spontaneous activity in the rat portal vein was investigated by comparing responses to oxygen and the respiratory chain inhibitors amobarbital and cyanide. With the inhibitors, O2 consumption (FO2) is uniformly decreased throughout the cell mass, and thus O2 gradients in the tissue are avoided. Hence the effects are not to be attributed to all-or-none inhibi

Localized Surface Plasmon Resonance Sensing of Lipid-Membrane-Mediated Biorecognition Events

Supported phospholipid bilayers (SPBs) have emerged as important model systems for studies of the natural cell membrane and its components, which are essential for the integrity and function of cells in all living organisms, and also constitute common targets for therapeutic drugs and in disease diagnosis. However, the preferential occurrence of spontaneous SPB formation on silicon-based substrate

Two-step recovery process for tryptophan tagged cutinase: Interfacing aqueous two-phase extraction and hydrophobic interaction chromatography

In this work, the interfacing of a poly(ethylene glycol) (PEG)-phosphate aqueous two-phase system with hydrophobic interaction chromatography (HIC) for primary recovery of an intracellular protein was evaluated. As a model protein, a recombinant cutinase furnished with a tryptophan-proline (WP) peptide tag was used and produced intracellularly in Escherichia coli (E. coli). E. coli cell homogenate

131I-labelled anti-CD22 MAb (LL2) in patients with B-cell lymphomas failing chemotherapy. Treatment outcome, haematological toxicity and bone marrow absorbed dose estimates.

The experience with radioimmunotherapy in B-cell lymphomas using the rapidly internalizing antibody, anti-CD22 (LL2), is limited. In this study we investigated the efficacy and toxicity of 131I-labelled-LL2 for radioimmunotherapy in patients with B-cell lymphomas that failed one or two cytostatic regimens. Eleven patients were treated with one or repeated cycles of 131I-anti-CD22 antibody, 1330 MB

Growth and characterization of defect free GaAs nanowires

Most III-V compound semiconductor nanowires seeded by metal particles grow preferentially in a (over bar 1 over bar 1 over bar 1)B direction (B wires) and most commonly with many stacking faults perpendicular to the growth direction. If growth proceeds in an alternate direction, defect-free growth has been observed. We present experimental results for the growth of GaAs nanowires in a previously u

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Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy.

To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk)