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TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
Aiming for the sixth generation (6G) wireless communications, distributed massive multiple-input multiple-output (MIMO) systems hold significant potential for spatial multiplexing. In order to evaluate the ability of a distributed massive MIMO system to spatially separate closely spaced users, this paper presents an indoor channel measurement campaign. The measurements are carried out at a carrier
The traditional multiscale approach couples two models operating at different scales. An alternative modelling strategy, called peridynamics originally developed by [1], is to continualize the molecular dynamic models, thus replacing inhomogeneities present on smaller length scales by an enhanced continuum description on larger length scales resulting in a nonlocal reformulation of continuum mecha
Uncertainty quantification (UQ) tasks, such as sensitivity analysis and parameter estimation, entail a huge computational complexity when dealing with input-output maps involving the solution of nonlinear differential problems, because of the need to query expensive numerical solvers repeatedly. Projection-based reduced order models (ROMs), such as the Galerkin-reduced basis (RB) method, have been
I uppsatsen undersöks lagregleringen om överskottsinformation vid användning av hemliga tvångsmedel i rättegångsbalken. Överskottsinformation är information som har med annat att göra än den utredning den hemliga tvångsåtgärden användes för. Lagändringen år 2023 innebär att informationen uttryckligen får användas för ”andra ändamål” än den ursprungliga utredningen vilket kan avse brott eller helt The essay examines the legal regulation on excess information when using secret measures of surveillance in the Code of Judicial Procedure . Excess information is information that pertains to matters other than the investigation for which the secret measure of surveillance was used. The 2023 legislative amendment explicitly allows the information to be used for “other purposes” than the original i
Popular Abstract in Swedish Brist på fria radikaler kan ge artrit Fagocytiska celler i vårt immunförsvar producerar fria syre-radikaler för att eliminera fagocyterade (uppätna) mikroorganismer. Produktionen av dessa syre-radikaler sker med hjälp av ett enzymkomplex (NADPH oxidas) i cellmembranet samt i membranet på de fagosomer, innehållande mikroorganismer, som bildas i och med fagocytos. MännisThe aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. Paper I a
Popular Abstract in Swedish Vävnadskallikrein (VK) är ett äggvitespjälkande protein som dels kan aktivera vävnadsnedbrytande enzymer som kollagenas och gelatinas och dels spjälkar kininogen till kininer (bradykinin och kallidin). Via bindning till speciella kininreceptorer (B2 receptorer) som finns överallt i kroppen, styr kininerna olika processer i de flesta av kroppens organ och vävnader såsom Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland
Popular Abstract in Swedish Artiodactyla (partåiga hovdjur) är uppdelad i tre underordningar, Suiformes (grisar och flodhästar), Tylopoda (kameler och lamor) och Ruminantia (kor, hjortar, antiloper och giraffer). Studien syftade till att analysera släktskapen mellan de olika underordningarna och ordningen Cetacea (valar) genom att sekvensera mitokondrie DNA och jämföra sekvenserna. I våra släktskArtiodactyla (eved-toed ungulates) and Cetacea (whales) are two mammalian orders that are commonly recognised as sistergroups. Recently it has been suggested that Cetacea originated within Artiodactyla, but the relationships among the different artiodactyl lineages and Cetacea have not been conclusively established. In the present study the mitochondrial genome of the pig (Sus scrofa), the hippopo
About 10% of the patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNSTs), accounting for half of all MPNST cases. Several nonrandom chromosomal aberrations have been found, but the target genes remain mostly unrecognized. Mutations in the NF1 and TP53 genes have been found in some MPNSTs, and recent data from mouse models support a synergistic effect
The extant mammalian groups Monotremata, Marsupialia and Placentalia are, according to the ‘Theria’ hypothesis, traditionally classified into two subclasses. The subclass Prototheria includes the monotremes and subclass Theria marsupials and placental mammals. Based on some morphological and molecular data, an alternative proposition, the Marsupionta hypothesis, favours a sister group relationship
Slipped-strand mispairing at sites containing so-called coding repeats (CRs) can lead to phase variation of surface proteins in Gram-negative bacteria. This mechanism, believed to contribute to virulence, has so far not been identified in a Gram-positive bacterium. In the genome of the Gram-positive human pathogen Streptococcus pyogenes, we identified pentanucleotide CRs within a putative signal s
It is currently unclear how often genes that are mutated to cause rare, early-onset monogenic forms of disease also harbor common variants that contribute to the more typical polygenic form of each disease. The gene for MODY3 diabetes, HNF1 alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and previous association studies have suggested a weak trend towa
Popular Abstract in Swedish Andelen vindkraft i elnätet har ständigt ökat under de senaste åren. I många länder utgör idag vindkraften en betydande del av den totala elproduktionen. Detta gäller även vid störningar då vindkraftverk – precis som vattenkraftverk och kärnkraftverk – måste fortsätta bidra till balansen mellan elproduktion och förbrukning. De nya reglerna för anslutning av vindkraft tiSynchronous generators have always been the dominant generation type in the grid. This fact affected both planning and operation of power systems. With the fast increase of wind power share in the grid in the last decade, the situation is changing. In some countries wind power represents already a consistent amount of the total generation. Wind turbines can be classified as non-synchronous generat
Embedded computer systems are subject to a multitude of requirements. These include real-time requirements, that is, such computers must respond to external events within limited time. Many systems, such as satellites and telephone switches, must also operate unattended for long periods of time. They must not fail due to defective software. Modern object-oriented programming languages, particular
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods:
Evolutionary changes in geographic distribution and larval host plants may promote the rapid diversification of montane insects, but this scenario has been rarely investigated. We studied the rapid radiation of the butterfly genus Colias, which has diversified in mountain ecosystems in Eurasia, Africa, and the Americas. Based on a data set of 150 nuclear protein-coding genetic loci and mitochondri
Vecka 44 2016 Vecka 45 2016 31/10 1/11 2/11 3/11 4/11 7/11 8/11 9/11 10/11 11/11 9-12 Förel. Livsmedel Start eget arbete CH Maskrosen E121 10-12 Förel. Livsmedel + Matlagningsmetoder i storkök CH Maskrosen E121 9-16 Tid för eget studiebesök 9-16 Tid för eget studiebesök 9-12 Studiebesök storkök Hagalidskolan, Staffanstorp 9-12 Förel. Märkning Mats Krook 9-12 Studiebesök storkök Järnåkra, Lund 9-12
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven21_finalt_schema_161025_v._2.pdf - 2026-07-17
Hedersrelaterade våldsbrott är något som förekommer även i Sverige. Vi har dock ingen lagstiftning i Sverige som reglerar dessa brott. Begås ett våldsbrott där motivet varit hedersrelaterat, döms gärningsmännen i enlighet med de övriga våldsbrotten som regleras i 3 och 4 kap brottsbalken. Syftet med detta arbete är att undersöka vad bristen på lagreglering avseende de hedersrelaterade våldsbrotteHonor-related violence is something that also occurs in Sweden. However we have no legislation in Sweden that regulate these offenses. Committing a violent crime where the subject was honor-related, convicted offenders in accordance with the other violent crimes governed by Chapters 3 and 4 Penal Code. The purpose of this work is to investigate the lack of statutory regulation concerning the honor
The evolution of globular star clusters tells the history of the formation of galaxies, how stellar streams might have formed and how the future of the Universe might look like. Although the general theoretical background of the evolution is well understood, it is difficult to conduct accurate and realistic computer simulations of objects containing thousands of interacting bodies. This project in
