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Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid Dexamethasone (Dex) on these responses.Design: Bovine cartilage explants were treated with either cytokines alone (10 ng/ml TNFα, 20 ng/ml IL-6, 100 ng/ml
Future hydrological droughts in reservoir-regulated regions remain uncertain due to the complex interactions between climate change and reservoir operation. Existing studies usually rely on simplified empirical representations of historical reservoir operations and rarely consider the role of optimal reservoir operation policies. Here, we used the upper Hanjiang River basin (UHRB) in China as a ca
Background: Early substitution of calcineurin inhibitor (CNI) with mammalian target of rapamycin inhibitors has been shown to improve kidney function and reduce intimal hyperplasia in heart transplant (HTx) recipients but data on long-term outcome of such a regime are still sparse. Methods: In the SCHEDULE trial, 115 de novo HTx recipients were randomized to (1) everolimus with reduced exposure of
Purpose: To address key issues of low SNR and image distortions in prostate diffusion MRI (dMRI) by means of using strong gradients, single-shot spiral readouts and an expanded encoding model for image reconstruction. Methods: Diffusion-weighted spin echo imaging with EPI and spiral readouts is performed on a whole-body system equipped with strong gradients (up to 250 mT/m). An expanded encoding m
Objectives To follow up four previously identified classes 'pure axial spondyloarthritis' (axSpA) ('axial'), 'axSpA with peripheral signs' ('inflammatory back pain+peripheral'), 'axSpA at risk' and 'no spondyloarthritis' ('no SpA'). They reflect the expert-opinion-free construct or 'Gestalt' of chronic back pain suspicious of axSpA. The aim was to assess participants' transitions between these cla
PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODSPatients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association b
Light-level geolocators were used to record the annual migration cycles of black terns Chlidonias niger (9 individuals, 11 journeys) and common terns Sterna hirundo (7 individuals, 11 journeys) breeding in southernmost Sweden. The black terns used two different non-breeding (Oct–Mar) regions along the Atlantic coast of Africa, either north of the equator between Senegal and Liberia (3 individuals)
Misfolding, self-assembly, and subsequent deposition of amyloid β plaques and tau tangles are closely associated with Alzheimer’s disease (AD) and its neurodegenerative processes, driving healthy neurons into a diseased state. At present, AD is the most widespread form of dementia, causing profound personal and familial hardship as well as imposing a substantial societal economic burden.Currently,The purpose of the work that forms the basis of this thesis has been to investigate fundamental properties of amyloid β and tau self-assembly and their solubility. The results of this research are presented as five research articles. In Paper I, a solubility assay for determining the solubility of amyloid proteins is developed and its use demonstrated for the Aβ40 peptide. Paper II finds that tau
A new encapsulation strategy for probiotics is highly needed to tackle the challenge of significant viability loss of bacteria during storage and passage through the gastrointestinal system. A new controlled delivery system for probiotics based on EC oleogels is proposed in this thesis. A relatively non-complicated in vitro lipolysis model was established to evaluate the relative conversion from t
Objective: This study aimed to report the initial experience with a novel bidirectional double cuff inner branch design for incorporation of renal and mesenteric arteries in patients undergoing fenestrated and branched endovascular aortic repair (F/BEVAR). Methods: A retrospective review was undertaken of the experience of F/BEVAR with grafts integrating at least one bidirectional double cuffed in
In ultrarelativistic heavy ion collisions at the LHC, each nucleus acts a sources of high-energy real photons that can scatter off the opposing nucleus in ultraperipheral photonuclear ((Formula presented)) collisions. Hard scattering processes initiated by the photons in such collisions provide a novel method for probing nuclear parton distributions in a kinematic region not easily accessible to o
Antipsychotics are mainly used for severe psychiatric disorders. Risperidone is the only antipsychotic approved for younger children. Aripiprazole is approved for older children, ziprasidone and lurasidone for adolescents. To describe paediatric utilisation of antipsychotic drugs in Sweden. Dispensations of antipsychotic drugs to children aged 5–17 years from 2008 to 2021 were analysed using the N
Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re
4MOST,1 the 4m Multi-Object spectrographic Survey Telescope, is an upcoming optical, fiber-fed, MOS facility for the VISTA telescope at ESO's Cero Paranal Observatory (Chile). The preliminary design of 4MOST features 2,400 fibers split into a low-resolution (1,600 fibers, 390-900 nm, R > 5; 000) and a high-resolution channel (800 fibers, three arms, ∼20-25 nm coverage each, R > 18; 000) with an Ec
Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. Th
In order to generate high-voltage high-pulsed power, klystron modulators necessarily contain at least one capacitor bank charging structure supplying the energy to be released during the pulse. Conventional charging structures are based on ac/dc front-end units typically based on diode rectifiers combined with power charging structures operated in on/off mode as a second stage, producing prohibiti
Purpose: To model prediction of undetected glaucoma in a predominantly white population, based on intraocular pressure (IOP) and subject age. Methods: In 1992–1997, a population screening for glaucoma was performed at Malmö University Hospital where individuals between 55–79 years of age (n = 46 614) living in Malmö, were invited to a free eye health examination. Recently examined patients were no
SUMMARY: Antibody repertoires reveal insights into the biology of the adaptive immune system and empower diagnostics and therapeutics. There are currently multiple tools available for the annotation of antibody sequences. All downstream analyses such as choosing lead drug candidates depend on the correct annotation of these sequences; however, a thorough comparison of the performance of these tool
Eligibility criteria for hematopoietic stem cell transplantation (HSCT) in acute lymphoblastic leukemia (ALL) vary according to disease characteristics, response to treatment, and type of available donor. As the risk profile of the patient worsens, a wider degree of HLA mismatching is considered acceptable. A total of 138 children and adolescents who underwent HSCT from HLA-identical sibling donor
PurposeTo estimate Swedish experience-based value sets for EQ-5D health states using general population health survey data.MethodsApproximately 45,000 individuals valued their current health status by means of time trade off (TTO) and visual analogue scale (VAS) methods and answered the EQ-5D questionnaire, making it possible to model the association between the experience-based TTO and VAS values
