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Urinary tract infections (UTIs) are clustered in certain individuals but the molecular basis of disease susceptibility is not known. A single gene was shown to control the susceptibility to acute pyelonephritis and renal scarring in mice. The IL-8 receptor homologue (mIL-8Rh) controls neutrophil function during acute infection and the mIL-8Rh deletion causes tissue damage through neutrophil entrap
Popular Abstract in Swedish Nya operationsmetoder för trokantära höftfrakturer – klinisk och biomekanisk utvärdering av Medoff´s glidplatta och Twin hook Akademisk avhandling av Ola Olsson Sammanfattning på svenska Benskörhet är en folksjukdom som bidrar till uppkomst av en rad typfrakturer. Till dessa hör höftfrakturer, som utgör ett folkhälsoproblem och en stor utmaning för samhällets sjuvårdsIn allowing compression along the femoral shaft (uniaxial dynamization) and optional compression along the femoral neck (biaxial dynamization), the Medoff sliding plate (MSP) represents a new principle in the fixation of trochanteric hip fractures. The Twin hook with 2 apical hooks was designed as an alternative to the lag screw. In 3 prospective consecutive case series and 1 prospective randomize
Background— The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins. Methods and Results— Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were de
This thesis is done in cooperation with Dresser Wayne AB in Malmö and the objective has been to investigate if it is possible to use the X-flo meter, see Figure 1, in an LPG-dispencer. An increased pressure is used in the LPG-system, which involves a higher risk of leaking and strength problems. During the development consideration has been taken to a new outlet, though other couplings are used in
This thesis project was to develop a module for a forest precision seeder. The project is made at BCC AB. BCC is a worldwide supplier of forest seed centre and containerized nursery equipment. BCC develops, designs, produces and sales machines for forest seed handling. BCC s existing precision seeder can not handle seed that are tinier than 1 mm in diameter. With a growing market in countries with
Background: Recent experiments have confirmed that the neutron-rich isotopes F28,29 belong to the so-called island of inversion (IOI), a region of the nuclear chart around Z=10 and N=20 where nuclear structure deviates from the standard shell model predictions due to deformation and continuum effects. However, while the general principles leading to the IOI are relatively well understood, the deta
Objectives: The prevalence of several autoimmune diseases, including thyroid dysfunction, has been reported to be increased in patients with endometriosis. Upregulated thyroid stimulation hormone (TSH) receptors in ectopic endometrium and elevated serum titers of TSH receptor antibodies (TRAb) IgG in endometriosis patients indicates an overlap in pathophysiology. However, cross-reactivity with oth
Background: In advanced Parkinson's disease (PD), dyskinesias and non-motor symptoms such as sleep dysfunction can significantly impair quality of life, and high-quality management is an unmet need. Objective: To analyze changes in dyskinesia and non-motor symptoms (including sleep) among studies with levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Methods: A comprehensive l
Background: Previous studies have reported Blood type O to confer a lower risk of SARS-CoV-2 infection, while secretor status and other blood groups have been suspected to have a similar effect as well. Study design and methods: To determine whether any other blood groups influence testing positive for SARS-CoV-2, COVID-19 severity, or prolonged COVID-19, we used a large cohort of 650,156 Danish b
Timely diagnosis of Alzheimer's disease (AD) is critical for appropriate treatment/patient management. Cerebrospinal fluid (CSF) biomarker analysis is often used to aid diagnosis. We assessed analytical performance of second-generation (Gen II) Elecsys® CSF immunoassays (Roche Diagnostics International Ltd), and adjusted existing cut-offs, to evaluate their potential utility in clinical routine. A
Background: Physical inactivity is a main cause of childhood obesity which tracks into adulthood obesity, making it important to address early in life. Physical activity on prescription (PAP) is an evidence-based intervention that has shown good effect on physical activity levels in adults, but has not been evaluated in children with obesity. This project aims to evaluate the prerequisites, determ
BACKGROUND: Triglyceride-glucose (TyG) index is a useful low-cost marker of insulin resistance. We aimed to evaluate the association between TyG index and arterial stiffness, incidence of diabetes, adverse cardiovascular outcomes, and all-cause and cardiovascular mortality in two large prospective Swedish cohorts, the Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CV) and the Malmö Preven
Aim: Understanding how climate conditions influence plant–pollinator interactions at the global scale is crucial to understand how pollinator communities and ecosystem function respond to environmental change. Here, we investigate whether climate drives differences in network roles of the main insect pollinator orders: Diptera, Coleoptera, Lepidoptera and Hymenoptera. Location: Global. Time period
The EU Biodiversity strategy aims to plant 3 billion trees by 2030, in order to improve ecosystem restoration and biodiversity. Here, we compute the land area that would be required to support this number of newly planted trees by taking account of different tree species and planting regimes across the EU member states. We find that 3 billion trees would require a total land area of between 0.81 a
Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family mem
Background:Sensory overresponsivity (SOR) has emerged as a potential endophenotype in obsessive-compulsive disorder (OCD), but few studies have examined SOR in relation to the major symptom dimensions of OCD and to symptoms across the full obsessive-compulsive (OC) symptom spectrum.Objective:This study had 2 main objectives. First, we examined the psychometric properties of the SOR Scales in a com
Background: Preventing and responding to gender-based violence (GBV) is both a human rights imperative and a multifaceted economic issue. GBV can also act as a barrier to economic empowerment. The aim of the study was to examine the association between women’s empowerment (physical mobility, decision making and economic resources) and GBV among married youth in India. Methods: Community based cros
Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps
BACKGROUND: In Bangladesh, diarrhoea in children under-five is a major public health problem with cost implications. Although under-five diarrhoea mortality and morbidity have declined from 2007 to 2018, change in the economic burden is unknown. This study determined the change in the societal economic burden of under-five diarrhoea in Bangladesh comparing 2007 to 2018.METHODS: A prevalence-based,
The aim of the creation of this cohort was to investigate patterns of health and health care utilisation before and during the COVID-19 pandemic, overall and in relation to specific diagnoses, among people with intellectual disabilities (ID) compared to the general population. People living in Skåne, the southernmost region of Sweden, on 1st of January 2014 with at least one diagnosis of ID (ICD-1
