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Introduction: Knowledge of longitudinal progression in mild Alzheimer’s disease (AD) is required for the evaluation of disease-modifying therapies. Our aim was to observe the effects of long-term cholinesterase inhibitor (ChEI) therapy in mild AD patients in a routine clinical setting. Methods: This was a prospective, open-label, non-randomised, multicentre study of ChEI treatment (donepezil, riva
Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRC
Background: Recent reviews conclude an association between traffic-related pollution and incidence of asthma in children, but not all studies agree. Studies have almost exclusively relied on parental-reported symptoms or parental-reported diagnoses of asthma and wheeze. Our aim was to investigate if traffic exposure is associated with higher incidence of early onset asthma, using registry-based ou
Background: The objective was to investigate in a group of obese subjects the course in skeletal muscle phospholipid (SMPL) fatty acids (FA) during a 24-weeks weight maintenance program, which was preceded by a successful very low calorie dietary intervention (VLCD). Special focus was addressed to SMPL omega-3 FA, which is a lipid entity that influences insulin action. Methods: Nine obese subjects
Background: Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978-2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods: The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical
Achieving a sustainable Swedish industry will require better utilization of resources already available and already spent. Nationally, vast amounts of heat are released into the atmosphere and not made use of. If only a fraction of this energy could be exploited, the path to net zero emission society by 2045 would be thousands of tons worth of CO2 closer. In Sweden, 25% of excess heat delivered to
Climate change, the energy crisis of 2022-2023, and estimations of future electricity demands have stressed the necessity for a rapid transition of the energy system. Offshore wind energy plays an important role in this transition, and is expected to expand considerably on a global level, in the EU and in Sweden. While Swedes show high support of wind energy, a majority of recent projects have bee
The ability of thermoresponsive, amine-functionalized microgel particles to take part in microgelmicrogel inter-cross-linking has previously been reported in the literature, in connection to applications such as for example the formation of stimuli-responsive colloidal gels and colloidosomes [1]. This thesis deals with the synthesis of such thermoresponsive, cross-linkable microgels and their subs
Purpose: The aim of this paper is to find out how the PMM system can be used to remain resilient to a change in the environment and so continue to provide appropriate guidance to managers in real time. Methodology: The paper is based on a qualitative research method with primarily an abductive approach to derive insight about a PMM system’s use to remain resilient to a change in the environment.
Recently, several regions in southern Sweden suffered extremely low groundwater levels following a long-term infrequency in rainfall. In response, irrigation was banned in many of the affected municipalities during 2016–2017, amongst which Mörbylånga municipality was one. Because nearly half of the nation’s drinking water is extracted from groundwater, protecting and managing this vital resource i
Blood loss in the first days of life has been associated with increased morbidity and mortality in very preterm infants. In this systematic review we included randomized controlled trials comparing the effects of interventions to preserve blood volume in the infant from birth, reduce the need for sampling, or limit the blood sampled. Mortality and major neurodevelopmental disabilities were the pri
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melb
BackgroundPopulations of long-distance migratory birds experience different environments and are consequently exposed to different parasites throughout their annual cycles. Though, specific whereabouts and accompanied host-parasite interactions remain unknown for most migratory passerines. Collared sand martins (Riparia riparia) breeding in the western Palaearctic spend the nonbreeding period in A
Background: This study investigates the patterns of PET-positive lymph nodes (LNs) in anal cancer. The aim was to provide information that could inform future anal cancer radiotherapy contouring guidelines. Methods: The baseline [18F]-FDG PET-CTs of 190 consecutive anal cancer patients were retrospectively assessed. LNs with a Deauville score (DS) of ≥3 were defined as PET-positive. Each PET-posit
The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet been defined. Two genes under direct control of SOX11 are the class- III β-tubulin gene (TUBB3) in neural cells and the transcription factor
Even though floral scent is of major importance for pollinator attraction, it is less investigated than other floral traits. Previous studies suggest the importance of joint exploration of olfactory and visual floral cues to understand plant–pollinator interactions. We investigated flower scents in Collinsia heterophylla, a bee-pollinated, annual herb a with mixed-mating system combining self- and
Objective The current study aimed to check whether early vascular aging, measured as carotid-femoral pulse wave velocity (cfPWV), is related to kidney function, measured as creatinine-based estimated glomerular filtration (eGFR) and urinary albumin-to-creatinine ratio (UACR), in middle-aged subjects with metabolic syndrome. Methods Participants were recruited from Lithuanian high-risk cohort (LitH
Purpose: To evaluate the long-term predictive value of the need to treat patients referred by optometric practitioners, regarding glaucoma, in Malmö, Sweden, using intraocular pressure (IOP) as the primary referral criterion. Patients and Methods: This retrospective study included 94 of 108 (87%) individuals referred to the Skåne University Hospital in Malmö, Sweden, for elevated IOP during 2012–
