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Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2013 there were twelve themed workshops, three of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of placental function, cell turnover and immunology: 1) immunology; 2) novel determinants o
Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for beta-cell autoantibodies and diabetes. Genetic testin
BACKGROUND: Conventional dosages of cytostatics in mg/m2 will cause marked variations in systemic exposure, resulting in over- and under-treatment, at least with respect to side effects.PATIENTS AND METHODS: We are conducting a randomized adjuvant study for breast cancer patients younger than 60 years of age with > or = 70% risk of recurrence within five years. The first 89 consecutive patients wh
Significance Our results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy
The hippocampus is a primary region affected in Alzheimer's disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathogenesis by comparing patient-based model systems including iPSC-derived brain cells transplanted into
Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via inter
Research shows that today’s societal crises are rooted in a lack of connection to ourselves, others and nature. At the same time, there is an increasing body of knowledge showing that humans possess innate capacities for connection that can be strengthened through certain methods, and throughout our lifetimes. Such methods have, so far, however, been rarely applied, or adapted to the context of su
Ultrasound Optical Tomography (UOT) combines the high-resolution imaging capability of ultrasound with measurements of light absorption and scattering properties of human tissue. This non-invasive technique could distinguish between cancerous and non-cancerous lesions inside the breast tissue, follow tumor shrinkage during preoperative treatment, or provide information on blood oxygenation levels.
Background: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arreBackground: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arre
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien
Background: Out of hospital cardiac arrest (OHCA) is a significant public health problem associated with high mortality and high healthcare costs. The Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) randomised clinical trial showed that targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months compared to normocapnia after OHCA. We aimed to est
Background: Outcome measurement is essential to progress clinical practice and improve patient care. Aim: To develop a Core Outcome Set for best care for the dying person. Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the
Stödgrupper för barn som växer upp i familjer med psykisk ohälsa, skadligt bruk/beroende eller våld är en insats som erbjuds av socialtjänsten i många kommuner. Trots att stödgrupper ges på frivilliga grunder utan biståndsprövning, dvs ”lätt tillgängligt” (Prop.2024/25:89), är rekryteringen av barn en utmaning. Denna licentiatuppsats fördjupar kunskapen om de förhållanden och överväganden som påveIn Sweden, preventive support groups for children exposed to domestic violence, substance abuse or mental illness in the home are provided by child welfare services (CWS). Support groups for children are often accessible without assessment, available for families to access at their own request, without formal referral or opening a case file which is assumed to lower the threshold. A current approa
PURPOSE: To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association.EXPERIMENTAL DESIGN: Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed
