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Brain-machine interfaces (BMIs) provide a uni- or bidirectional communication link between the central nervous system and the outside world. This link facilitates the studying of neuronal mechanisms underlying behavior as well as the treatment of neurological disease. Wired BMIs are limited in the sense that they restrict the mobility of the subject and they increase the risks for post-surgical co
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Introduktion Adrenokortikotropiskt hormon (ACTH) stimulerar frisättningen av steroid¬hormoner, främst kortisol, från binjurarna. Kortisol är livsnödvändigt och finns alltid i blodet och förhöjs kraftigt vid stress. I början av 90-talet fann vår forskningsgrupp en koppling mellan ACTH och fettomsättningen som inte involverade steroidhAbstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB synthesis, seen in hepatic cell systems, is als
Interactions between danger and pathogen-associated molecular patterns (DAMP and PAMP) and pattern recognition receptors such as Toll-like receptors (TLRs) are critical for the regulation of the inflammatory process via activation of NFκB and cytokine secretion. In this report, we investigated the capacity of LPS-free S100A9 (DAMP) protein to activate human and mouse cells compared to lipoprotein-
The aim of this research was to analyze the effects and the modes of action of elemental sulfur (So) in bioluminescence and respiration of Vibrio fischeri cells and the enzymes crude luciferase, pure catalase, and alcohol dehydrogenase (ADH). Metallic copper removed sulfur and reduced the toxicity of acetone extracts of sediment samples analyzed in the bioluminescence test. The sulfur inhibition o
Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine
This paper presents a picoliter sample preparation technique utilizing the flow-through principle, allowing on-line coupling of chromatographic systems to be made. The work was performed in order to investigate the characteristics and the physicochemical properties of the sample preparation using typical mobile phase conditions from μ-CLC (column liquid chromatography) separations. The device pres
An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of aneuploid cells remains low throughout life in most normal tissues. This implies that newly formed aneu
Background and Objectives The aim of this study was to evaluate the pharmacokinetics, efficacy and safety of a newly developed 10% liquid immunoglobulin preparation in patients with primary immunodeficiency diseases. This new preparation for intravenous use includes three dedicated virus clearance steps in its manufacturing process to ensure a high margin of viral safety. Materials and Methods Thi
Within the framework of the European Land Arctic Physical Processes project and as part of the Danish Research Council's Polar Program, a study on trace gas exchange in a high-arctic ecosystem was conducted in NE Greenland, May-August 1997. On the basis of carbon dioxide flux measurements from three dominant surface types, this paper reports on the upscaling of such measurements from canopy to lan
UPPSATSENS TITEL: Den Femte Positioneringsfällan SEMINARIEDATUM: 2013-05-28 ÄMNE/KURS: Magisteruppsats i företagsekonomi 30 högskolepoäng (ECTS), FEKN90 FÖRFATTARE: Stina Cedergren och Malin Svensson HANDLEDARE: Jens Hultman Fem nyckelord: varumärkespositionering, varumärkesidentitet, förändringsprocessen, positioneringsfällor, yngre och kvinnlig målgrupp SYFTE: Syftet med uppsatsen är att
Solar radiation is affected in a variety of different ways through the atmosphere and on its way down to the Earth’s surface. Clouds are the main factor in this attenuation of solar radiation, but aerosols, ozone and other different gases have a significant impact too. Understanding these processes is fundamental to solar forecasting. However, the atmosphere is constantly changing, which makes for
This research analyses the presence of political personalisation and its role in establishing performed authenticity in political content on TikTok. Despite TikTok being a platform created for entertainment purposes, TikTok has come to play a significant role in political discourse and engagement with politicians Employing a qualitative approach to Multimodal Critical Discourse Analysis, this rese
Ambient airborne particles with an aerodynamic diameter of <2.5 µm (PM2.5), which contain particles from combustion processes, are linked to increased risks for cardiovascular and respiratory diseases. In this experimental study, the short-term and long-term physiologic consequences of PM2.5 inhalation were investigated with the focus on inflammatory parameters and vascular tonus. PM2.5 collected
This scientific report has mainly studied the concept of Industry 4.0 and the possibility to send data from a temperature sensor to the cloud, a process which is an example of the term Internet of Things. The study has been conducted for the consultant business Rejlers to give the CEO as well as the Technical Manager a broader view of how they could implement IoT on behalf of costumers in the futu
Examensarbetets titel: Shared service center inom revisionsbranchen Seminariedatum: 30 maj, 2024 Ämne/kurs: FEKH69 Examensarbete i redovisning på kandidatnivå, 15 högskolepoäng Författare: Olivia Elldalen, Julius Landin, Linnea Mårtensson Handledare: Alexander Hedlund Fem nyckelord: Shared service center, delivery center, revisor, tillit, revisionsbyrå Forskningsfrågor: Hur och varför använde
Abstract Objective: The small intestinal epithelium is a highly complex system continuously renewed by a process involving cell proliferation and differentiation. In mammals, the physiological function of intestine is not fully mature at birth, and many factors could accelerate gut maturation. In the current study we hypothesized that the pancreatic enzymes could be one of such factors. In the sa
Land-use change affects both the quality and quantity of soil organic carbon (SOC) and leads to changes in ecosystem functions such as productivity and environmental regulation. Future changes in SOC are, however, highly uncertain owing to its heterogeneity and complexity. In this study, we analyzed the outputs of simulations of SOC stock by Earth system models (ESMs), most of which are participan
Nonradical-based advanced oxidation processes (AOPs) catalyzed by defective carbonaceous materials have exhibited great superiorities in trace antibiotics removal from natural water matrices. However, the complicated, extensive and highly-energy consumed synthesis methods are seriously hindering its development and application. Herein an in-situ electrochemical synthesis technology was developed a
