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Background: Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. Methods: PSA- and hK2-specific monoclonal antibodies were used in solid-phase, two
OBJECTIVE: To adapt the Knee injury and Osteoarthritis Outcome Score (KOOS) into French and to evaluate the psychometric properties of this new version. METHODS: The French version of the KOOS was developed according to cross-cultural guidelines by using the "translation-back translation" method to ensure content validity. KOOS data were then obtained in patients with symptomatic knee osteoarthrit
Popular Abstract in Swedish Varje dag produceras miljardtals nya blodceller, vilka exempelvis har som uppgift att transportera runt syre och försvara kroppen mot olika invaderande bakterier och virus. Dessa olika blodkomponenter har sitt ursprung i sällsynta blodbildande stamceller som återfinns i benmärgen. Dessa är så kallade vävnadsspecifika stamceller och har både förmågan att återbilda sig sjBlood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation process that results in the production of mature effector blood cells. Aging is characterized
The overall aim of this thesis was to describe the experiences of obstetricians and parents and the attitudes of midwives in relation to critical situations during pregnancy and birth. The data collection (Paper I and II) started in year 2000 with interviews with obstetricians (n=14) concerning the meaning of being in ethically difficult situations. During 2002 to 2004 interviews with parents (n=2
Contamination of soil and water by heavy metal ions (HMs) is a problem all over the world.The use of biological methods alone or in combination with other techniques for treatment of such polluted sites constitutes a major challenge. The present thesis summarizes work based on four basic technologies: 1) use of Sulphate Reducing Bacteria (SRBs) for production of hydrogen sulphide which is used to
The purpose of this study was to investigate women's wishes and need for knowledge concerning sexuality and relationships in connection with gynecological cancer. A total of 11 women were interviewed following the completion of their treatment for gynecological cancer. The data was analyzed using latent content analysis. Two main categories were identified: "The absence of knowledge about the body
The Department of Physics at Lund University is participating in a European Union project called EUMAPP (European Union Microdose AMS Partnership Programme), in which sample preparation and accelerator mass spectrometry (AMS) measurements of biological samples from microdosing studies have been made. This paper describes a simplified method of converting biological samples to solid graphite for C-
Smoking is a risk factor for developing chronic obstructive pulmonary disease (COPD), but there are no good indicators for early identification of subjects who will develop symptomatic COPD. The aim of this study was to investigate inflammatory mechanisms related to changes in lung function and emphysematous changes on high resolution computed tomography (HRCT) in 'healthy' smokers. Subjects were
In patients with radiculopathy due to degenerative disease in the cervical spine, surgical outcome is still presenting with moderate results. The preoperative investigations consist of clinical investigation, careful history and most often magnetic resonance imaging (MRI) of the cervical spine. When MRI shows multilevel degeneration, different strategies are used for indicating which nerve root/ro
Age-associated and degenerative loss of functional integrity in soft tissues develops from effects of cumulative and subtle changes in their extracellular matrix (ECM). The highly ordered tendon ECM provides the tissue with its tensile strength during loading. As age and exercise collude in the high incidence of tendinopathies, we hypothesized that aged tendons fail due to cumulative damage result
The available energy (AE), driving the turbulent fluxes of sensible heat and latent heat at the earth surface, was estimated at four partly complex coniferous forest sites across Europe (Tharandt, Germany; Ritten/Renon, Italy; Wetzstein, Germany; Norunda, Sweden). Existing data of net radiation were used as well as storage change rates calculated from temperature and humidity measurements to final
Many cyber-physical systems comprise several control applications sharing communication and computation resources. The design of such systems requires special attention due to the complex timing behavior that can lead to poor control quality or even instability. The two main requirements of control applications are: (1) robustness and, in particular, stability and (2) high control quality. Althoug
Many embedded systems comprise several controllers sharing available resources. It is well known that such resource sharing leads to complex timing behavior that degrades the quality of control, and more importantly, can jeopardize stability in the worst-case, if not properly taken into account during design. Although stability of the control applications is absolutely essential, a design flow dri
Although many studies have been made for homogenous constant diffusion, bone is an inhomogeneous material. It has been suggested that bone porosity decreases from the inner boundaries to the outer boundaries of the long bones. The diffusivity of substances in the bone matrix is believed to increase as the bone porosity increases. In this study, an experimental set up is used where bovine bone samp
Six-membered cyclic carbonates are potential monomers for phosgene and/or isocyanate free polycarbonates and polyurethanes via ring-opening polymerization. A two-step process for their synthesis comprising lipase-catalyzed transesterificationofa polyol, trimethylolpropane(TMP) with dimethylcarbonate(DMC)in a solvent-free system followed by thermal cyclization was optimized to improve process effic
Degradation of organic matter takes place in many processes within a wastewater treatment plant (WWTP). The need for optimisations and extended degradation processes for both organics and nitrogen will increase as outlet demands are strengthened and increasing loads are desired. The purpose of this work was to study the degradation of organic matter at WWTPs within two areas in particular; 1) d
Widespread presence of toxic and persistent pollutants in the environment, even at low concentrations, causes risks of adverse effects to human health and the ecosystem. Biological methods for treatment of water streams and removal of persistent pollutants are of great interest due to their simplicity, low cost, and mild operational conditions without harmful by-products. The purpose of this resea
This study deals with the diffusion of a new medical technology — vaccination against smallpox — in nineteenth-century Scania in Sweden. Using an aggregated sample of parishes as well as a micro-level dataset for four parishes, we investigate the socioeconomic as well as the geographical patterns of diffusion of vaccination in the province. We also relate the adoption of vaccination across geograp
The ductility of Al alloys is dictated by the nucleation, growth and coalescence of small internal voids originating from intermetallic particle fracture and from the presence of pre-existing porosity. The ductility is degraded when intermetallic particles are large and clustered. A low ductility adversely impacts both forming operations and the integrity of structural components. Local stirring u
