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C-terminal TFPI-1-derived peptides: their evolutionary host defense functions

Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin

Defining extended half-life rFVIII-A critical review of the evidence

Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient

Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

Bacteria-immunoglobulin-lymphocyte interactions--new aspects

Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on

Hungry Eyes

Friday, at 19:00 – Performance "Immanuel, Immanuel!" by Hungry Eyes Hungry Eyes is a Danish–Swedish performance collective founded by Theatre Academy alumni Dina Viksten Abrahamson, Ida Østman, Mie Kristensen and Olivia Klang. At IAC, they present their second work Immanuel, Immanuel! – a conceptual exploration of the choir as form and method. A choir without choral singing, an essayistic, hopeful

https://www.iac.lu.se/hungry-eyes - 2026-05-31

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Lärares kompetenser och medvetna val - i en digitaliserad skola Karin Ollinen Kommunlicentiand - CSIS Helsingborgs stad, IT-pedagogiska frågor Handledare Pernilla Nillson (Högskolan i Halmstad) Roger Nilssin (Campus Helsingborg) Syfte Skapa en större medvetenhet kring lärares olika professionella kompetenser (ramverket TPACK), hur de samverkar därmed drar nytta av teknikens möjligheter. Brainstorm

https://www.uvet.lu.se/fileadmin/user_upload/uvet/Licentiandutbildningen/Dokument/Karin_Ollonen__forskning.pdf - 2026-05-30

ID3-SD: an algorithm for learning characteristic decision trees by controlling the degree of generalization

Decision trees constructed by ID3-like algorithms suffer from an inability of detecting instances of categories not present in the set of training examples, i.e., they are discriminative representations. Instead, such instances are assigned to one of the classes actually present in the training set, resulting in undesired misclassifications. In this report, twomethods of reducing this problemby le

Skåne, den farliga halvön. Historia, identitet och ideologi 1865-2000

Scania, the dangerous peninsula. History, identity and ideology 1865 to 2000 This dissertation deals with the organized written history of Scania 1865 to 2000 and the intersection of history, identity and ideology. Under what circumstances were the history produced and circulated? What was its significance for identity and ideology alike? The theoretical and analytical inspiration is drawn from P

Localizing Ashkenazic Jews to Primeval Villages in the Ancient Iranian Lands of Ashkenaz

The Yiddish language is over 1,000 years old and incorporates German, Slavic, and Hebrew elements. The prevalent view claims Yiddish has a German origin, whereas the opposing view posits a Slavic origin with strong Iranian and weak Turkic substrata. One of the major difficulties in deciding between these hypotheses is the unknown geographical origin of Yiddish speaking Ashkenazic Jews (AJs). An an

In-Store Recycling - A Consumer Perspective

Syftet med uppsatsen är att studera hur ett segment av Generation Y ser på in-store recycling - en tjänst myntad av författarna till arbetet. In-store recycling är en tjänst som många fast fashion retail-bolag har börjat erbjuda genom att placera insamlingslådor för kläder som konsumenter vill ha återvunnet eller återanvänt, och i retur får konsumenten en belöning i form av en rabattkupong. För at

Interaction of Nanometric Clay Platelets

The free energy of interaction between two nanometric clay platelets immersed in an electrolyte solution has been calculated using Monte Carlo simulations as well as direct integration of the configurational integral. Each platelet has been modeled as a collection of charged spheres carrying a unit charge-the face of a platelet contains negative charges, and the edge, positive charges. The calcula

Redesigning a closed-loop supply chain exposed to risks

Supply chain management includes coordination and motivation of independently operating partners. Therefore, it is important to align logistics structures, processes and incentives, especially when making major changes involving those components. Traditionally, cost, quality, and service have served as prioritized performance indicators for supply chains, but lately risk is also taken into conside

Community-level birth rate: a missing link between ecology, evolution and diversity

We propose a conceptual model to explain the variation in species richness in local communities and in build-up of regional species pools over time. The idea is that the opportunity for new species to enter a community (its invasibility) determines the present richness of that community as well as the long-term build-up of a species pool by speciation and migration. We propose that a community's i

Fair and efficient justice Archives - Page 2 of 2 - The Raoul Wallenberg Institute of Human Rights a

Fair and efficient justice Archives - Page 2 of 2 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Eval

https://rwi.lu.se/news-categories/fair-and-efficient-justice/page/2/ - 2026-05-31

Att förbättra eller förinta? - En granskning av folkmordsbegreppet ur ett rättsutvecklingsperspektiv

Den här uppsatsen syftar till att ur ett rättsutvecklingsperspektiv redogöra för och diskutera framväxten av det internationella brottet folkmord (genocide). Raphael Lemkin myntade 1944 begreppet genocide. Han hade då också en genomtänkt definition av vad begreppet behövde innebära för att omfatta de illdåd som utförs i världen. Bakgrunden till hans engagemang grundade sig i det turkiskottomanska