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This thesis consists of six articles on three different subjects in the area of complex analysis, operator theory and harmonic analysis. Part I - "The Shift Operator on Spaces of Vector-valued Analytic Functions" consists of three closely connected articles that investigate certain operators in the Cowen-Douglas class with spectrum D - the unit disc, or equivalently, the shift operator M_z
At present, air conditioning (AC) is the most effective means for the cooling of indoor space. However, its increased global use is problematic for various reasons. This is a correspondence to the supplementary opinion provided by Dr. Bin Yang, Dr. Stefano Schiavon, and Dr. Faming Wang to our paper titled “Challenges of using air conditioning in an increasingly hot climate.” The paper explored the
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airway remodeling, including emphysema and fibrosis. Proteoglycans and their glycosaminoglycan (GAG) chains are key components of the extracellular matrix and may be altered as the disease advances. This study analyzed lung tissue from COPD patients (GOLD stages II-III and IV), non-COPD smokers, and non-smoker
Background: Survivors of cardiac arrest often face multifaceted challenges—cognitive, emotional, physical, and existential—that extend beyond clinical recovery. Despite these long-term consequences, follow-up care is often insufficient, and access to reliable information and support remains limited. Broader initiatives to address post–cardiac arrest care are still lacking. This qualitative study rBackground: Survivors of cardiac arrest often face multifaceted challenges—cognitive, emotional, physical, and existential—that extend beyond clinical recovery. Despite these long-term consequences, follow-up care is often insufficient, and access to reliable information and support remains limited. Broader initiatives to address post–cardiac arrest care are still lacking. This qualitative study r
Genetic determinants underlying most human blood groups are now clarified but variation in expression levels remains largely unexplored. By developing a bioinformatics pipeline analyzing GATA1/Chromatin immunoprecipitation followed by sequencing (ChIP-seq) datasets, we identify 193 potential regulatory sites in 33 blood-group genes. As proof-of-concept, we aimed to delineate the low-expressing com
Most definitions of cancer broadly conform to the current NCI definition: "Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body." These definitions tend to describe what cancer "looks like" or "does" but do not describe what cancer "is" or "has become." While reflecting past insights, current definitions have not kept pace with the underst
Background: Accurate blood type data are essential for blood bank management, but due to costs, few of 43 blood group systems are routinely determined in Danish blood banks. However, a more comprehensive dataset of blood types is useful in scenarios such as rare blood type allocation. We aimed to investigate the viability and accuracy of predicting blood types by leveraging an existing dataset of
The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-resistance to classes of therapies with independent mechanisms of action. We hypothesize that this can occur through PACC memory, whereby cancer cells that have
Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use a transparent phosphorescent thin film to visualize the self-generated hypoxia field of prostate cancer cells and quantify local O2 consumption rates, mea
Recent research has indicated that machining of titanium alloys with uncoated cemented tungsten carbide tools fulfil the criteria for Kirkendall porosity. If this occurs during machining, it could contribute to the type and rate of tool wear, compromising the tools structural integrity close to the edge line within the contact zone. In this study, voids were observed at the tool-workpiece contact
Tumor hypoxia plays a critical role in cancer progression and therapeutic resistance. Here, we present a protocol for the self-generation of hypoxia by metastatic cancer cells using phosphorescence-based O2 sensing. We describe steps for phosphorescent film calibration, system assembly, and real-time imaging of hypoxia development. We then detail approaches to spatially map resulting O2 gradients.
Carbon Fibre-Reinforced Polymers (CFRP) are a fast growing market of high performance materials and components. Thermally induced damage during machining processes such as drilling or routing are among the limiting factors for product quality, yet accurate temperature measurement remains challenging. This study develops a methodology which combines machinable thermocouples and IR thermometry techn
Thin-film thermocouples (TFTCs) are critical for real-time temperature monitoring in advanced manufacturing processes where conventional sensors fail due to spatial constraints or complex geometries. This study develops K-type TFTCs on stainless steel 316 L substrates with optimized SiO₂/SiO insulation layers for industrial deployment. In particular, two types of stainless steel substrates were in
Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD
Hard-to-heal wounds are a growing human and financial concern, constituting approximately 1–3% of the healthcare budget. Wound care is not a medical specialty and is often not prioritized within healthcare. A large portion of the cost and suffering caused by wounds has the potential to be mediated through improved knowledge and effectivised workflows. One potential way to achieve this is through t
Inköpspolicy FÖRSÄTTSSIDA STYRDOKUMENT Inköpspolicy Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsstyrelsen Beslutsdatum: 2024-1
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-11/inkopspolicy.pdf - 2026-07-25
Mutations in the glucocerebrosidase (GBA) gene have been associated with the development of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line was generated from a 60-year old patient diagnosed with PD and carrying a new mutation variant p.R301C in GBA. Using non-integrating Sendai virus-based technology, we utilized OCT3/4, SOX2, c-MYC and KLF4 transcription factors to reprogr
