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Cancer and autoimmunity: two sides of the same coin. Complement system proteins in the regulation of immune responses.

Factor H is an inhibitor of the complement system, essential for controlling the alternative pathway and also playing a crucial role in various cellular functions. In this thesis, we identified new intriguing functions of FH as a survival factor for primary human monocytes, promoting their differentiation into immunosuppressive macrophages. We showed that FH is expressed by human breast cancer cel

Coins have both sides : Revealing the structure and pattern of global interdependence network for five critical metals

Evaluating the trade interdependence among countries is the key to understanding critical metal minerals security. By constructing a novel interdependence network, this paper reveals a more comprehensive world hierarchy and risk system of critical metals, and focuses on the interdependencies between China and the US-led MSP countries before and after the Sino-US trade disputes. The results indicat

Two sides of the same coin?

Purpose: This study’s purpose is to study the long term effects of M&A and to examine whether stock price is the only determinant of post-merger performance or if operating performance can be used as an additional determinant. How underlying variables impact these measures are also part of this study´s purpose. Methodology: A quantitative approach is used where two event studies are conducte

Two Sides to the Same Coin: The Dual Life of Consultants in Employee and Employer Branding

Purpose: This research aims to gain an understanding on how consultants in small consultancies, who also hold internal human resource responsibilities, promote their organisation in employee and employer branding. Relevance: Due to the ambiguous consultancy profession and the high potential for individual influences on the corporate brand, branding becomes a very germane topic in our particular r

Two Sides of the Same Coin? A Preliminary Analysis of Sustainable Development Opportunities Identified in National Communications of Non-Annex I Parties

The aim of this paper is to study the extent to which non-Annex I countries are implementing or exploring select actions that support both climate change mitigation and sustainable development objectives in the energy sector. The research is based on a survey of the national communications of 100 non-Annex I Parties to the UNFCCC. Although national communications are intended to provide informatio

Aggressive pituitary tumours and carcinomas : two sides of the same coin?

The European Society of Endocrinology (ESE) survey reported on the largest cohort of 125 aggressive pituitary tumours (APT) and 40 pituitary carcinomas (PC). Whilst the survey focused on treatment effectiveness, all pathological data were not explored in detail. Here, we comment on some interesting pathological findings, notably the difference between APT and PC.

The Other Side of the Coins : The Environmental Impact of Greenfield FDI in Sub-Saharan Africa´s Pollution-Intensive Industries and the Role of Governance

While foreign direct investments (FDI) are promoted as a vehicle for economic development their environmental consequences are less estab-lished. This study tests the hypotheses that 1) FDI led to environmental deg-radation in form of increased greenhouse gas emissions during Sub-Saharan Africa´s recent growth spurt but that 2) this impact was felt to a lesser extent in countries with a higher qua

Two Sides of the Same Coin? A Preliminary Analysis of Sustainable Development Opportunities Identified in National Communications of Non-Annex I Parties

The aim of this paper is to study the extent to which non-Annex I countries are implementing or exploring select actions that support both climate change mitigation and sustainable development objectives in the energy sector. The research is based on a survey of the national communications of 100 non-Annex I Parties to the UNFCCC. Although national communications are intended to provide informatio

Public diplomacy and development communication : Two sides of the same coin?

This chapter seeks to develop a theoretical basis for better understanding the intersections between public diplomacy (PD) and development communication (Devcom). It will be argued that both fields involve (1) theories of influence over social change in foreign countries; (2) a voluntary transfer of resources from an actor promoting a specific cause or agenda to a group or organization in a foreig

Coagulation Systems of Invertebrates and Vertebrates and Their Roles in Innate Immunity: The Same Side of Two Coins?

Bacterial infections represent a serious health care problem, and all multicellular organisms have developed defense mechanisms to eliminate pathogens that enter the host via different paths including wounds. Many invertebrates have an open circulatory system, and effective coagulation systems are in place to ensure fast and efficient closure of wounds. It was proposed early on that coagulation sy

Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin?

Soft tissue sarcoma (STS) diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extremity soft tissue UPS with the aim of identifying molecular subtype signatures and genomic prog

Bet on both sides of the coin to improve the organizational climate: The impact of congruent task and role clarity between leaders and staff

Four organizations at Stockholm-Arlanda airport are going through various organizational changes. They are preparing for present and future demands through structural changes, implementation of new technology, training, and other efficiency and capacity improving measures. The change processes will be followed during two years of which this paper presents the baseline measurement. The key factors

The other side of the coin: the e-government implementation in an Italian municipality

This paper ad to the body of knowledge on the implementation ofthe e-Government and aims to describe how this process was carried out inthe Delta municipality in Northern Italy. This organization is a public organization in an economically important Region and provides services to entrepreneurs such as validation for opening a new business. An interpretativeapproach used with several interviewees