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The expression levels of fetal hemoglobin (HbF) in bacterial recombinant systems are higher compared with normal adult hemoglobin (HbA). However, heme disorientation in globins are often observed in recombinant production processes, both for HbA and HbF, although the degree of heme oriental disorder is much lower for HbF. In addition, the heme disorientation can be converted to a normal conformati
Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the pr
Abstract in Undeterminedhe paper is based on selected findings of the research project EEC 2092/91 (Organic) revision. It contributes to an improved understanding of the core ethical values associated with and principles of organic farming, analyses reference to such values in the European Regulation (EEC) 2092/91 and its ongoing revision, and contrasts them with current practice of organic agricu
Aim Understanding what constituted species ranges prior to large-scale human influence, and how past climate and land use change have affected range dynamics, provides conservation planners with important insights into how species may respond to future environmental change. Our aim here was to reconstruct the Holocene range of European bison (Bison bonasus) by combining a time-calibrated species d
Diamine oxidase (DAO) is an enzyme involved in the regulation of cell proliferation and the immune response. This enzyme performs oxidative deamination in the catabolism of biogenic amines, including, among others, histamine, putrescine, spermidine, and spermine. The mechanistic details underlying the reductive half-reaction of the DAO-catalyzed oxidative deamination which leads to the reduced enz
The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenyl-propane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product enantiomers. In order to understand the differences in the stereoconfigurations of the products, the reactions were studied kinetically during both th
One of the best systems for exploring the origin of enzyme catalysis has been the reaction of ketosteroid isomerase (KSI). Studies of the binding of phenolates to KSI have been taken as proof that the electrostatic preorganization effect only makes a minor contribution to the binding of the real, multiring, transition state (TS). However, our simulation study has determined that the difference bet
Integrating low-power wearable systems into routine health monitoring is an ongoing challenge. Recent advances in the computation capabilities of wearables make it possible to target complex scenarios by exploiting multiple biosignals and using high-performance algorithms, such as Deep Neural Networks (DNNs). However, there is a tradeoff between the algorithms' performance and the low-power requir
Objectives: Dupuytren disease is a common condition that causes progressive finger contractures resulting in impaired hand function and difficulties in performing daily activities. Patient reported outcome measures (PROMs) are commonly used in research and clinical practice to evaluate treatment outcomes. Both general upper extremity PROMs and Dupuytren-specific PROMs are available, typically deve
Purpose: There is a need for a simple, non-invasive, and easily accessible 3D imaging technique for the anophthalmic socket to create imaging data for future 3D printing of prostheses. This study aimed to investigate the feasibility of using a novel handheld tomographic ultrasound for 3D mapping of the anophthalmic socket. Methods: Ten anophthalmic sockets were scanned using a tomographic ultrasou
The number of degrees of freedom is a crucial parameter in many electromagnetic problems. In for example modern communication systems spatial diversity is often employed through multiple beams to enhance capacity and reliability. However, while the degrees of freedom can be computed, their connection to physical quantities is not as easily understood. To address this issue, this paper proposes a s
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of clustering of care activities for promoting development and preventing morbidity in preterm infants.
Background: Preterm and low birth weight infants are at an early stage of development, and do not receive adequate maternal circadian signals. They are often cared for over prolonged periods of hospitalisation in neonatal intensive care units (NICU), where environmental circadian stimuli are lacking. Exposure to artificial light–dark cycles may stimulate the development of the circadian system and
Decarbonization policies require public support to be implemented and to remain in legislation. Examinations of public support for climate policies tend to focus on asmall number of policy instruments and/or use hypothetical instead of real policy proposals. Here, we address these criticisms by examining public support acrossfour distinct policy instruments– command-and-control, market-based, info
This study bridges occupational health and innovation management by proposing psychosocial safety climate (PSC) as a key precondition for employee-driven innovation (EDI). EDI emphasises employees’ unique potential to generate and implement innovative ideas, with conducive working conditions, particularly those supporting psychological health, being crucial. Using a mixed-method explanatory design
