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Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non–muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatmen

BACKGROUND: The wasabi receptor, also known as the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel, is a potential target for development of repellents for insects, like the pine weevil (Hylobius abietis) feeding on conifer seedlings and causing damage in forestry. Heterologous expression of TRPA1 from pine weevil in the yeast Pichia pastoris can potentially provide protein for structur

Importance: Meningioma is the most common subsequent neoplasm following cranial irradiation among survivors of childhood cancer, but there are still uncertainties regarding the magnitude of the radiation dose-response association, potential modifiers of radiation risks, and the role of chemotherapy. Objective: To evaluate meningioma risk in survivors of childhood cancer following radiotherapy and

The subject matter of the thesis is the comprehensive - legal and multidisciplinary - analysis of the terms 'peoples' and 'minorities' in international law. The argument of the author proceeds in four parts: the Problematique which deals with the 'minority challenge' and the international normative response to that challenge; the Critique, criticizing the basic underlying assumptions of the discou

Med ett politiskt parti anklagat för fascism i riksdagen, och nynazister marscherande på gatorna är frågor om demokrati och frihet viktigare än någonsin. Var bör yttrandefrihetens gränser dras? Bör den överhuvudtaget begränsas? Syftet med den här uppsatsen är att utforska en möjlig lösning till de problem som dagens demokrati står inför. Det här åstadkoms genom en konstruktion av ett konceptuellt With a political party accused of fascism in the Swedish parliament and neo-nazis marching in the streets, questions of democracy and freedom of expression are as important as ever. Where to draw the boundaries of the freedom of expression? Why have, or limit, such freedoms in the first place? The purpose of this thesis is to investigate a possible solution to the problems facing contemporary demo

Skatteflykt är ett problem för många av världens suveräna stater. Det finns olika metoder för att bemöta problemet, vanligast är att en stat väljer att instifta en lagstiftning med en generalklausul eller att genom praxis utveckla riktlinjer för när en transaktion skall anses vara skatteflykt. I Sverige och Australien har lagstiftarna valt att genom generalklausuler försöka bekämpa skatteflykt. SyTax avoidance is an issue for many of the sovereign states of the world. Different methods are used in different countries to combat tax avoidance, the most common forms of anti-avoidance measure is either using legislation consisting of a general anti-avoidance rule or using case law to develop general guidelines for when a transaction should be considered tax avoidance. In Sweden and Australia t

This thesis addresses business performance indicators in the context of the Circular Economy (CE) and the textile industry. Its purpose is to explore possible design features of Circular Performance Indicators (CPIs) in the textile industry, to examine the application of such metrics among retailers and to define potential indicators for the Swedish fashion retailer MQ. The research design is exp

Purpose: According to literature there is a set of six key competencies that distinguish sustainability professionals, including researchers, from professionals and researchers in other fields, making them “systemic problem solvers, change agents, and transition managers”. However, there is lack of empirical evidence, first, that these skills are necessary and sufficient for sustainability problem

Den 30 mars 2017 presenterade Finansdepartementet Vissa frågor inom fastighets- och stämpelskatteområdet (SOU 2017:27), även kallat paketeringsutredningen. Förslagen som utredningen presenterade innebär bland annat att transaktioner med paketerade fastigheter ska beskattas symmetriskt med lagfartsöverlåtelser, till skillnad från nuläget då de kan ske skattefritt genom försäljning av näringsbetingaOn March 30th 2017 the special appointed committee from the Swedish Treasury Department presented Vissa frågor inom fastighets- och stämpelskatteområdet (SOU 2017:27), also known as “paketeringsutredningen”. Suggestions from the public investigation include among other things amendments stating that transactions of incorporated real estate should be taxed symmetrically with traditionally transacti

Syftet med denna uppsats är att analysera Fackföreningslagen och dess potentiella konsekvenser för fackföreningars föreningsfrihet i den kambodjanska textilindustrin. Utöver detta analyseras lagen i förhållande till redan befintlig nationell lagstiftning samt i relation till internationell rätt rörande föreningsfrihet. Majoriteten av Fackföreningslagens regleringar är oförenliga med internationeThe aim of the thesis is to elaborately analyse the Trade Union Law and its possible implications for trade unions’ right to freedom of association in the Cambodian garment industry. In addition, the law is evaluated in relation to already existing domestic law and in relation to international law regarding freedom of association. The majority of the Trade Union Law’s provisions are incompatible

Today, one of the most important questions around the world is that of climate change and the battle against carbon emissions. Wind power has proven to be the most successful option among renewable energy sources, and it is a crucial tool in the race to cut our carbon emissions and to safe security of supply within the EU. Until now, most of the development has occurred onshore, but offshore wind

Problem Statement Thule is the world leading developer and manufacturer of transportation solutions. Their company strategy is to enable active families, professionals and outdoor enthusiasts to transport equipment by vehicle safely, easily and in style. RV users of today have higher demands on their equipment and they fill their cars with every type of conveniences found in a modern home. With

The “peer to peer” (P2P) is a technology of downloading and filesharing between online - Internet - users by the mean of specified software. Since June 1999, the Napster software has made the happiness of millions of individuals who used it to obtain and share free audio files Mp3. Rapidly, the major recording companies have prosecuted the Napster Company and managed to force it to close down. The

Background: The search for a biomarker of Alzheimer's disease (AD) pathology (amyloid-β (Aβ) and tau) is ongoing, with the best markers currently being measurements of Aβ and tau in cerebrospinal fluid (CSF) and via positron emission tomography (PET) scanning. These methods are relatively invasive, costly, and often have high screening failure rates. Consequently, research is aiming to elucidate b

This paper presents a new direct electron transfer based-miniaturized glucose/oxygen enzymatic fuel cell (EFC) whose operating ability has been tested in real saliva samples. The bioanode and biocathode are a graphene working electrode and a graphite counter electrode localized on the same screen printed electrode (SPE) modified with poly(vinyl alcohol) N-methyl-4(4'-formylstyryl)pyridinium methos

Suddträsket är ett internationellt erkänt våtmarksområde av stor betydelse som ligger beläget längst Vita Nilen i Sydsudan. Våtmarkens unika ekologiska miljöer har lett till skapandet av flera naturskyddsområden för bevarandet av de naturliga habitaten och dess ovärderliga ekosystemtjänster. Tillsyn av skyddsområdena bidrar i allmänhet till deras bevarande. Däremot har de pågående politiska osäkerThe Sudd wetland, situated along the White Nile in the Republic of South Sudan, is recognized internationally for its unique environmental features. The distinctive ecological characteristics have resulted in the creation of numerous nature reserves in efforts to conserve the habitats and ecosystem services provided. Monitoring changes within the nature reserves usually contributes to their protec

AbstractModern medicine and health care rely on a variety of diagnostic and therapeutic equipment and methods that involve ionizing radiation. To guarantee quality and the safety of patients and staff, advanced radiation detectors and dosemeters are needed that have low energy and operate with directional independence for X-ray and γ-ray photons. Similar instruments are also of great importance fo

Background: Organ involvement often occurs in early systemic sclerosis and has been related to premature death. Identifying patients at diagnosis at risk of developing early organ involvement would be useful to optimize screening and management strategies. Objective: To develop prediction models for the 5-year development of interstitial lung disease, pulmonary arterial hypertension and death. Met

The active site of sulfite reductase (SiR) consists of an unusual siroheme–Fe4S4 assembly coupled via a cysteinate sulfur, and serves for multi-electron reduction reactions. Clear explanations have not been demonstrated for the reasons behind the choice of siroheme (vs. other types of heme) or for the single-atom coupling to an Fe4S4 center (as opposed to simple adjacency or to coupling via chains

Background: To assess balance in single-limb stance, center of pressure movements can be registered by stabilometry with force platforms. This can be used for evaluation of injuries to the lower extremities. It is important to ensure that the assessment tools we use in the clinical setting and in research have minimal measurement error. Previous studies have shown that the ability to maintain stan