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Background and Objectives. From 1994 to 1997 we conducted a population-based, prospective study on intensive therapy in newly diagnosed symptomatic myeloma patients younger than 60 years, comparing their survival to that of a conventionally treated historic population. Long-term results are presented, including the impact of the degree of response on survival and relapse pattern after transplantat
This paper reports the results of a search for strong production of supersymmetric particles in 20.1 fb(-1) of proton-proton collisions at a centre-of-mass energy of 8 TeV using the ATLAS detector at the LHC. The search is performed separately in events with either zero or at least one high-p (T) lepton (electron or muon), large missing transverse momentum, high jet multiplicity and at least three
Introduction Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended-release (ER) oral morphine. A recent large phase III study suggests the subgroup most likely to benefit have chronic obstructive pulmonary disease (COPD) and modified Medical Research C
The results of a search for the direct pair production of top squarks, the supersymmetric partner of the top quark, in final states with one isolated electron or muon, several energetic jets, and missing transverse momentum are reported. The analysis also targets spin-0 mediator models, where the mediator decays into a pair of dark-matter particles and is produced in association with a pair of top
Flavor-changing neutral currents are not present in the Standard Model at tree level and are suppressed in loop processes by the unitarity of the Cabibbo-Kobayashi-Maskawa matrix; the corresponding rates for top quark decay processes are experimentally unobservable. Extensions of the Standard Model can generate new flavor-changing neutral current processes, leading to signals which, if observed, w
A search for new charged massive gauge bosons, W′, is performed with the ATLAS detector at the LHC. Data were collected in proton–proton collisions at a center-of-mass energy of s=13 TeV and correspond to an integrated luminosity of 36.1 fb−1. This analysis searches for W′ bosons in the W′→tb¯ decay channel in final states with an electron or muon plus jets. The search covers resonance masses betw
We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War, based on a considerable body of contemporary sources. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for i
Background:Esophageal atresia (EA) is a congenital malformation affecting 1:3000-4500 newborns. Approximately 15% have a long-gap EA (LGEA), in which case a primary anastomosis is often impossible to achieve. To create continuity of the esophagus patients instead have to undergo lengthening procedures or organ interpositions; methods associated with high morbidity and poor functional outcomes. Eso
We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for inland areas. Coastal areas industrialized through stea
OBJECTIVE: Health system resilience can increase a system's ability to deal with shocks like floods. Studying health systems that currently exhibit the capacity for resilience when shocked could enhance our understanding about what generates and influences resilience. This study aimed to generate empirical knowledge on health system resilience by exploring how public antenatal and childbirth healt
Exercise Doppler echocardiography (EDE) is a well-validated tool in ischemic and valvular heart diseases. However, its use in the assessment of the right heart and pulmonary circulation unit (RH-PCU) is limited. The aim of this study is to assess the semi-recumbent bicycle EDE feasibility for the evaluation of RH-PCU in a large multi-center population, from healthy individuals and elite athletes t
Theoretical calculations of reaction kinetics were done for one‐step reactions catalyzed by cells immobilized in spherical beads. The reactions catalyzed by free cells were assumed to obey Michaelis–Menten kinetics for a one‐substrate reaction. Both external (outside the beads) and internal (inside the beads) mass transfer of the substrate were considered for the immobilized preparations. The theo
Background: Diseases of the bowel are not always displayed on conventional abdominal computed tomography (CT). The studied oral contrast agent aims to improve this. Purpose: To investigate whether the use of a novel oral contrast for abdominal CT enables the same diagnostic advantages as seen in magnetic resonance imaging (MRI). Material and Methods: Twenty-five consented volunteers drank up to 14
This contribution analyses the first decision by the Court of Justice of the European Union (CJEU) on the qualification and regulation of stand-alone software as medical devices. Referring to the facts of the case and the applicable EU regulatory framework, the Court specifically found that prescription support software may constitute a medical device. This would even be the case where the softwar
Summary: Osteoporotic fractures may pose a challenge for skeletal regeneration. This study investigates if pharmaceutical interventions such as bone morphogenetic protein 7 (BMP-7) alone or in combination with Zoledronate have equivalent efficacy in osteoporotic bone? Our findings suggest they do and that an osteoporotic bone environment may increase sensitivity to BMP-7. Introduction: Osteoporosi
Popular Abstract in Swedish Avhandlingen undersöker teologen Gustaf Wingrens (1910-2000) kyrkosyn och relaterar den till den nutida diskussionen om Svenska kyrkan som folkkyrka. Tre viktiga frågor ställs till Wingren och andra teologer och debattörer, som ingår i undersökningen, nämligen: Vad är kyrkan? (om kyrkans väsen). Vem är kyrka? (om gränser, medlemskap och auktoritet). Var är kyrkan? (om kThis thesis explores the ecclesiology of the Swedish theologian Gustaf Wingren and discusses the future of the "folk church". Three questions What, Who and Where is the Church? sustain the structure of this investigation. Wingren reflected on issues related to the openness and the identity of the church. His main concern was the interpretation the gospel as the liberating message to the guilt-ridd
Resultat fran undersökningen visar att personrisker (inklusive dödsrisken) vid brand i ett småhus är tämligen oberoende av husets konstruktion. Trähus och stenhus kan därför klassificeras som likvardiga. Egendomsskador påverkas förutom av husets innehåll och beskaffenhet även av husets utformning och konstruktion. En brännbar konstruktion, speciellt vindsbjälklag- och yttertakkonstruktion innebär
OBJECTIVE:: The aim of the trial was to compare laparoscopic technique with open technique regarding short-term pain, quality of life (QoL), recovery, and complications. BACKGROUND:: Laparoscopic and open techniques for incisional hernia repair are recognized treatment options with pros and cons. METHODS:: Patients from 7 centers with a midline incisional hernia of a maximum width of 10 cm were ra
