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The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell
Neurogenesis, the production of new neurons from neural stem cells, dramatically decreases during aging concomitantly with increased inflammation both systemically and in the brain. However, the precise role of inflammation and whether local or systemic factors drive the neurogenic decline during aging is poorly understood. Here, we identify CXCR5/5/CXCL13 signaling as a novel regulator of neuroge
De senaste åren har den digitaliserade gigekonomin och de nya arbetsformerna plattformsarbete och egenanställd etablerats i Sverige och övriga EU-länder. Gemensamt är att själva arbetet fragmentiserats och består av korta uppdrag åt ett flertal uppdragsgivare som förmedlas via en digital delningsplattform eller app. Den som utför en arbetsprestation gör det antingen som anställd eller som företaga
Ageing societies are facing major housing challenges. Understanding and addressing older adults' diverse housing needs and preferences are crucial. Having access to suitable and sustainable housing options can improve social cohesion, independence, health, and well-being. Participatory processes in housing development can enhance inclusion and democratic participation. This study uses Ramlösa Port
Background. The estimation of glomerular filtration rate (GFR) is one tool to detect renal disease. The most used biomarker remains serum creatinine and the European Kidney Function Consortium (EKFCcrea ) equation is the most validated in Europe. More recently, cystatin C has been proposed as a biomarker. We studied the performances of the EKFC equations in a large cohort of subjects according to
Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-indepen
We created an AI support for diagnosis in dyspneic adults at time of triage in the emergency department.Complete data from an entire regional health care system was analyzed, to find AI-derived, unknown, important diagnostic predictors. Most important were prior diagnoses of heart failure or COPD, daily smoking, atrial fibrillation/flutter, life difficulties and maternal care.Sensitivity for AHF,
Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here we show that the transition from a local to a systemic GAS infection is paralleled by pathogen-driven alterations in IgG homeostasis. Using animal models and a combination of sensitiv
BACKGROUND: Diagnostic testing is essential for disease surveillance and test-trace-isolate efforts. We aimed to investigate if residential area sociodemographic characteristics and test accessibility were associated with Coronavirus Disease 2019 (COVID-19) testing rates.METHODS: We included 426 224 patient-initiated COVID-19 polymerase chain reaction tests from Uppsala County in Sweden from 24 Ju
In the present study, we demonstrate an acoustofluidic trapping technique based on the standing bulk acoustic waves (S-BAW) generated inside a uniquely designed chamber - the 'shaped trap' that enables the particle to experience the axial primary radiation force (A-PRF) along the flow direction as the main trapping force.
Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno
Physics classrooms are still clearly marked by practices belonging to a certaineducational past, while teachers are increasingly being asked to teach in lignment with current equality, diversity and inclusion agendas. At the core of this temporal disconnect are teachers’ practices, which are strongly marked by normative regimes in terms of gender, race, ethnicity, class and other social factors. M
Populärvetenskaplig sammanfattning: Kvävebelastningen på sjöar och hav har ökat markant de senaste tiotal åren. Jordbruket står för ca 50 % av de svenska kväveutsläppen som människan bidrar till. En ökad kvävebelastning på haven kan leda till övergödning, vilket får en stor negativ effekt på vattenekosystemen. Ett sätt att minska övergödningsproblematiken är att öka vattnets uppehållstid i landskaPolitical decisions have resulted in more focus on how to optimize wetlands natural ability to lower nitrogen fluxes in order to minimize the problem with eutrophication in costal areas. However there is no exact knowledge how to calculate the effectiveness of nitrogen removal in wetlands with natural water flow due to the many biochemical and hydrological processes that interact. In this study tw
Användningen av mobila tjänster har ökat kraftigt de senaste åren, inte bara med privata abonnemang utan även vid användning med företagsmobiler. Vår undersökning syftar till att öka förståelsen för användande av SMS och MMS inom Svenska storföretag. Den modell vi utarbetat som stöd beskriver spridningen av SMS och MMS i organisationer. Den del av modellen vi undersöker behandlar innovationen, des
Nanoplastics are emerging environmental contaminants that increasingly threaten soil ecosystems, yet their effects on microbial behavior remain poorly understood. This is mainly due to the lack of experimental tools capable of directly observing microbial dynamics in situ under realistic soil-like conditions. Here, we present a proof-of-concept system that enables real-time, high-throughput monito
Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision-making and real-time experimental control. Here, we introduce a theoretical framework that reconceptualises sma
Exposure to natural environments is thought to benefit mental and physical health. A better understanding of the interplay between the individual and the environment in relation to public health is imperative in light of the joint biodiversity, climate, and health crises. This study aimed to 1) identify Body Mass Index (BMI) trajectories in the Scania Public Health Cohort (SPHC), 2) characterise t
Globalt Dynamiskt Engagemang Latinamerika 2024 1GDE LATINAMERIKA 2024 GDE Latinamerika GLOBALT DYNAMISKT ENGAGEMANG | 2024 2GDE LATINAMERIKA 2024 GDE Latinamerika Globalt engagemang är en självklar och nödvändig del i Lunds univer- sitets arbete för att kunna fortsätta utvecklas som ett internationellt ledande universitet som värnar demokrati, mänskliga rättigheter och akademisk frihet. Globalt dy
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-01/Ver%201_GDE%20Latinamerika%202024.pdf - 2026-06-28
Literature list Sustainability Science: The Field Development (MN) 1. Kates, Robert W., et al. (2001). Sustainability Science. Science 292(5517) (2 pages) 2. Clark, W. C. (Ed.). (2007). Sustainability science: A room of its own. Proceedings of the National Academy of Sciences (PNAS), 104(6), 1737-1738. (2 pages) 3. Spangenberg, J. H. (2011). Sustainability science: a review, an analysis and some e
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-01/PhD%20Course%20Literature%20List_25%20Jan.pdf - 2026-06-28
