Search results

KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress Neuron Article KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress Johan Jakobsson,1,2,5 Maria Isabel Cordero,1 Reto Bisaz,1 Anna C. Groner,1,2 Volker Busskamp,1,2 Jean-Charles Bensadoun,1 Florence Cammas,3 Régine Losson,3 Isabelle M. Mansuy,4 Carmen Sand

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_neuron.pdf - 2026-06-30

The use of polymers for the delivery of drugs has increased dramatically in the last decade. To ensure the desired properties and functionality of such substances, adequate characterization in terms of the molar mass (M) and size is essential. The aim of this study was to evaluate the changes in the M and size of PVP-b-PAMPS when the amounts of the synthesis reactants in the two-step radical react

A search for Higgs boson pair production in events with two b-jets and two τ-leptons is presented, using a proton–proton collision dataset with an integrated luminosity of 139 fb −1 collected at s = 13 TeV by the ATLAS experiment at the LHC. Higgs boson pairs produced non-resonantly or in the decay of a narrow scalar resonance in the mass range from 251 to 1600 GeV are targeted. Events in which at

Research within contingency theory recognizes and postulates the relevance of contextual factors to the design of organizations. Thus organizations are dependent on the environments in which they operate and on the technologies they utilize. Organizations therefore need to process information about their environments and technologies. Information systems, including computerized information sytems,

OBJECTIVES: In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) and coronary artery disease, undergoing transcatheter aortic valve replacement (TAVR), to determine how AS affects: 1) phasic coronary flow; 2) hyperemic coronary flow; and 3) the most common clinically used indices of coronary stenosis seve

Urbanization has led to significant infrastructural challenges, particularly in the slum areas of the Global South. Nature-based Solutions (NbS) are emerging as innovative approaches to enhance urban sustainability and resilience. This study investigates the enabling environment for decentralized governance in implementing NbS within urban slums, focusing on case studies in Indonesia and the Phili

The present thesis sought to inspect the yet-unexplored digital dimension of North Korean human rights activism, aiming to uncover the strategic digital communication wielded by a selected case study. The research was thus based on an explorative qualitative inquiry of the social media activity of Park Yeonmi, one of the most renowned North Korean defectoractivists in the West. A total of 90 eleme

Canals have always been an important part of The Netherlands and played a big role within the urban development of the cities. As many of the canals lost their functions by the 19th century, a lot were replaced with streets infrastructure. Replacing the canals with streets has affected the overall ambience of many neighbourhoods in The Netherlands. The elimination of the water element caused many

As one of the primary countries of destination for migrant domestic workers in Asia, Singapore is a developed country with one of the highest standards of living in the region. Yet, the city-state has been on the receiving end of extensive criticism concerning the rights and protections of migrant domestic workers. Civil society organizations have been one of the loudest critics, and in recent pub

Young adult novels about suicide are questioned pieces of literature. Fears of suicide contagion and the perceived unsuitability of such narratives for adolescents lie at the centre of this conflict, which has resulted in the banning of books and other censorship moves. Suicide in literature has been the focus of relatively scarce previous research, and there is a need for further literary critici

Action Research, Participatory Action Research and participatory methods have faced a number of criticisms, including that they do not actually involve citizens or create social change, and that they are tokenistic. This thesis develops and tests a new participatory method that contributes to a democratic and emancipatory PAR that responds to these criticisms and the shortcomings of current method

Extractivist projects are causing widespread socio-ecological destruction across Indonesia, impacting ecosystems, rural communities, and Indigenous ways of life. At the forefronts of socio-ecological collapse, women are increasingly taking up leadership roles in environmental activism. Simultaneously, women environmental defenders (WEDs) are experiencing a growing crisis of violent repression. Thi

Chronic respiratory diseases (CRDs) are a group of incurable conditions, among which the most common, such as COPD and asthma, have significant negative impacts on patients’ mental health and economic productivity. Understanding of the causes and affected populations of CRDs is continuously evolving, with air pollution now recognized as an important etiological factor alongside smoking, receiving

This thesis investigates the impact of U.S. sanctions imposed between 2010 and 2012 on Iran’s non-oil exports. Using the Synthetic Control Method (SCM) as the baseline strategy, complemented by an Event Study and a standard Difference-in-Differences (DiD) model, the analysis shows that sanctions led to a sharp and persistent decline in Iran’s export performance relative to a counterfactual scenari

With Artificial Intelligence (AI) relying heavily on vast datasets, including publicly available personal online data and increasing amounts of fines for data breaches the individuals demand for control over personal data increases. The purpose of this thesis is to analyze the efficacy of the GDPR in granting data subjects control over their personal data when they are used to train AI. Therefore,

Renewed scholarly interest in the category of history within the field of International Relations has prompted a revival of the so-called English School and its analytic emphasis on the concept of international society. This study examines the expansion of nineteenth century European international society through the theory of legal reception applied to the cases of Japan and the Ottoman empire. M

One of the target goals for sustainable development is the reduction of maternal mortality, which is a big health issue in some countries. Even if the research on maternal health care has come far and with the right expertise and supplies, almost all maternal deaths would be preventable. A working force to reduce the issues within maternal mortality in many countries are non-governmental organizat