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BACKGROUND: Risk factors for suicide and fatal accidental intoxication are extensively studied, while risk factors for intoxications/injuries of undetermined intent are less well known. The latter have shown an overlap with suicides, but also with fatal accidental intoxications. The objective was to analyze potential differences and similarities in the patterns of risk factors for accidental intox

Introduction Trastuzumab is part of the standard treatment for HER2-positive breast cancer. The aim of this study was to estimate the societal value of trastuzumab administered through subcutaneous (SC) injection compared to intravenous (IV) infusion. Methods Female patients with HER2-positive breast cancer receiving SC or IV trastuzumab were consecutively enrolled from five Swedish oncology clini

Introduction Fever is an integral part of the inflammatory response and has therefore likely a physiological role in fighting infections. Nevertheless, whether fever in itself is beneficial or harmful in adults is unknown. This protocol for a systematic review aims at identifying the beneficial and harmful effects of fever control interventions in adults. Methods and analysis This protocol for a s

Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. T

Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t

In four previous case-control studies we have shown an association between exposure to phenoxyacetic acids or chlorophenols and soft-tissue sarcoma (STS). These chemicals are contaminated by dioxins and dibenzofurans, some of which are known carcinogens in experimental animals. In a meta-analysis of our four studies we studied such exposure including the relation to tumour localization and histopa

A 4π radiation dosemeter for use in medical radiology was designed. It is based on a solid state silicon detector, a sensor wafer, a flex card, a 3D plastic holder and a spherical stainless steel filter with a distribution of holes around the detector. The detector is attached to the wafer using only low Z material. To achieve an energy and directional response which is as uniform as possible for

Populärvetenskaplig sammanfattning: Under de senaste 300 åren har jordbrukslandskapet i Sverige genomgått stora förändringar. Detta började med att bönderna i slutet av 1600-talet erhöll en stor del av adelns jord. De fick således förvalta sin egen vinst, vilket resulterade i en rad nyodlingar och tekniska hjälpmedel. I början av 1900-talet introducerades konstgödslet och efter andra världskriget Human-induced eutrophication has rapidly become one of the most important environmental issues. The problem is largely due to the shift in agricultural practices. Farming methods have become more efficient during the last 300 years. Watercourses have been straightened out and wetlands have been reduced to increase agricultural landuse. Since the end of the 1940s, fertilization has increased dramat

Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA). Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Ta

The study field of the thesis is regional integration in Africa. The focus is set on the African Union (AU) and its main programme for promoting democracy on the continent, the New Partnership for Africa´s Development (NEPAD). By applying two theories, one on democratization through regional organizations and the other on hidden agendas within them, the thesis makes an assessment on the work for d

The responses to step and pulse transients with reactants have been simulated for conventional step-transient conditions at atmospheric pressure and pulsing under vacuum using a temporal analysis of products (TAP) reactor, respectively. Propene oxidation over an oxide catalyst with the participation of lattice oxygen was chosen as a model reaction. The mechanism comprises adsorption of the reactan

Using two epochs of HST/WFPC2 images of the metal-rich globular clusterNGC 6528 we derive the proper motions of the stars and use them toseparate the stars belonging to NGC 6528 from those of the Galacticbulge. The stellar sequences in the resulting colour-magnitude diagramfor the cluster are significantly better determined than in previouslypublished data. From comparison of the colour-magnitude

The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by addition of a transmembrane (tm) sequence, and constituti