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Studies on fibre intake and incident colorectal cancer (CRC) indicate inverse associations. Differences by tumour stage have not been examined. We examined associations between fibre intake and its sources, and incidental CRC. Separate analyses were carried out on the basis of sex, tumour location and the Tumour, Node, Metastasis (TNM) classification. The Malmö Diet and Cancer Study is a populatio

Alzheimer’s disease (AD) is the most common cause of dementia, costing about 1% of the global economy. Failures ofclinical trials targeting amyloid-βprotein (Aβ), a key trigger of AD, have been explained by drug inefficiency regardlessof the mechanisms of amyloid neurotoxicity, which are very difficult to address by available technologies. Here, wecombine two imaging modalities that stand at oppos

The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family gene orthologs in mouse and human, is highly and specifically expressed in late terminal erythroid differentiation (TED). In this study, we investigated the role of Ypel4 in murine erythropoiesis, providing for the f

Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we performed ribonucleic acid sequencing of flow-sorted primitive (CD34+CD38low) and

Sea salt aerosol particles are highly abundant in the atmosphere and play important roles in the global radiative balance. After influence from continental air, they are typically composed of Na+, Cl-, NH4+, and SO42- and organics. Analogous particle systems are often studied in laboratory settings by atomizing and drying particles from a solution. Here, we present evidence that such laboratory st

Given that FLT3 expression is highly restricted on lymphoid progenitors, it is possible that the established role of FLT3 in the regulation of B and T lymphopoiesis reflects its high expression and role in regulation of lymphoid-primed multipotent progenitors (LMPPs) or common lymphoid progenitors (CLPs). We generated a Flt3 conditional knock-out (Flt3fl/fl) mouse model to address the direct role

INTRODUCTION: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florb

BACKGROUND: Diagnostic testing is essential for disease surveillance and test-trace-isolate efforts. We aimed to investigate if residential area sociodemographic characteristics and test accessibility were associated with Coronavirus Disease 2019 (COVID-19) testing rates.METHODS: We included 426 224 patient-initiated COVID-19 polymerase chain reaction tests from Uppsala County in Sweden from 24 Ju

Den här uppsatsens syfte är att uppmärksamma och analysera om och hur muslimerna på ön blir förtryckta samt att försöka bidra med medvetenhet och forskning. Iris Marion Youngs teori om förtryck vid namn Förtryckets fem ansikten används för att kunna studera materialet som utgörs av nyhetsartiklar och dokument från Amnesty. En innehållsanalys utförs på materialet där ett flertal förtryckande maktst

Höje å har de senaste 200 åren blivit 50 procent kortare och förlorat 90 procent av avrinningsområdets våtmarker. För att kunna klara av framtida behov gällande matproduktion och utbyggnad av städer krävs effektiv avvattning av landskapet. Traditionella diken är bra på att avvattna mark, men medför många nackdelar för biologisk mångfald och näringstransport från jordbruksmark till havet. Tvåstegsd

Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demo

Popular Abstract in Swedish Rehabilitering har sedan länge varit en viktig och naturlig del av behandlingen för personer med reumatiska sjukdomar. I denna doktorsavhandling om teambaserad rehabilitering för personer med kroniska reumatiska ledsjukdomar ges en uppdatering av kunskapsläget liksom en historisk bakgrund. De vetenskapliga resultat som redovisas i avhandlingen visar i korthet på följandThe aim of this thesis was to study outcome and evaluation of rheumatological multidisciplinary team rehabilitation programmes in patients with chronic inflammatory arthritis (CIA); rheumatoid arthritis (RA), ankylosing spondylitis, psoriatic arthritis and other spondyloarthritides, and to analyse health care utilization over the last decade in patients with RA. In Study I the outcome of an 18 da

Tracking techniques are vital for the understanding of the biology and ecology of organisms. While such techniques have provided important information on the movement and migration of large animals, such as mammals and birds, scientific advances in understanding the individual behaviour and interactions of small (mm-scale) organisms have been hampered by constraints, such as the sizes of existing

För att se om brand regimerna i Sverige före större antropogena påverkningar skett år jämförbara med nutida Kanadensiska brand regimer jämförde jag två datasets av brand storlek och antal bränder. Man kan se likheter när Kanada och Sveriges brand regimer jämfördes, men eftersom sökarean varierade mycket (Kanada: hela landet, Sverige: 608km2) och den temporala upplösningen (Kanada: 41 år, Sverige: To assess if the fire regimes in Sweden before the strong human intervention are comparable to the recent Canadian fire regime I compared two datasets of fire numbers. A likeness could be found when comparing the Swedish and Canadian fire regimes, but due to the differences in study area (Canada: the whole state; Sweden 608km2) and time span (Canada: 41 years, Sweden: 800 years), no significant re

Våld mot kvinnor i nära relationer är ett socialt problem som blivit mer uppmärksammat de sista åren. Dock är mycket av våldet fortfarande dolt och sker inom hemmets fyra väggar. Vi har intervjuat tre kvinnor som blivit utsatta för denna typ av våld och även professionella som hjälper dessa kvinnor, för att undersöka varför kvinnor stannar kvar hos sina män som slår dem, hur de får styrkan att läm

Vi har i vårt examensarbete undersökt Helsingborgs studentsituation på uppdrag av Helsingborgs Kommun. Redan nu är det bostadsbrist för Helsingborgs studenter och värre blir det i och med att studenterna förväntas nästan fördubblas dubbelt de närmaste fem åren. Därför behöver Helsingborg ett nytt studenthem omgående. Syftet med denna rapport har varit att utreda studenternas boendesituation i Hels

There is a long history of avian studies investigating the impacts of urbanization. While differences in several life-history traits have been documented, either between urban and rural populations or across generalized urbanization gradients, a detailed understanding of which specific environmental variables cause these phenotypic differences is still lacking. Here, we quantified several local en