Search results

Background Androgens acting via the androgen receptor (AR) stimulate production of prostate specific antigen (PSA), which is a clinical marker of prostate cancer (PCa). Since genetic variants in the AR may have a significant impact on the risk of being diagnosed with PCa, the aim was to investigate if AR-variants were associated with the risk of having PSA above clinically used cut-off thresholds

The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that are not fully understood. We identified the repressor element (RE)-1 silencing transcription factor (REST) as a mediator of AR actions on gene repression. Chromatin immunoprecipitation showed that AR binds chromatin regions containing well-characterized cis-elements known to mediate REST transcriptional rep

A reproducible and quantitative imaging biomarker to standardize the evaluation of changes in bone scans is an unmet need for prostate cancer patients with skeletal metastasis. Here we have performed a series of analytical validation studies to evaluate the performance of the automated Bone Scan Index (BSI) as an imaging biomarker in patients with metastatic prostate cancer (mPCa).

Background Preventive measures are needed to counteract the increasing burden of cutaneous malignant melanoma (CMM). As a basis for rational melanoma prevention, we investigated geographic differences and impact from socioeconomic factors related to incidence, clinical stage at diagnosis and outcome. Material and methods All patients with primary invasive CMM diagnosed in 2004-2013 in the southern

Background:Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and poor prognosis in several forms of cancer. In this study, we investigated the prognostic impact of PODXL expression in colorectal cancer (CRC).Methods:Using tissue microarrays and immunohistochemistry, PODXL expression was evaluated in 536 inci

Fluorescence lifetime determination has proven to be useful, e.g. identification of molecules, quantitative estimation of species concentration and determination of temperatures. Lifetime determination of exponentially decaying signals is challenging if signals of different decay rates are being mixed, resulting in erroneous results. Such issues occur when the contrast of the measurement object is

Recent advances in stroke treatment have provided effective tools to successfully treat ischemic stroke, but still a majority of patients are not treated due to late arrival to hospital. With modern stroke treatment, earlier arrival would greatly improve the overall treatment results. This prospective study was performed to asses the capability of bilateral accelerometers worn in bracelets 24/7 to

Lundsuniversitet_191105.indd KVALITETSDRIVNA • SAMVERKANDE • ENERGIGIVANDE • VÄRDESKAPANDE Välkommen till KC Group KC Group stödjer kompetensutveckling och förändringsprocesser inom offentlig sektor över hela Sverige. Vi har specialiserat oss på chefscoachning av individer, team och ledningsgrupper. KC Group designar och levererar även skräddarsydda chefsutbildningsprogram, workshops, seminarier o

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/kc_group.pdf - 2026-05-27

Transcriptional profiling of epithelial ovarian cancer has revealed molecular subtypes correlating to biological and clinical features. We aimed to determine gene expression differences between malignant, benign and borderline serous ovarian tumors, and investigate similarities with the well-established intrinsic molecular subtypes of breast cancer.

ARTICLE Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study Maria Lönnrot1,2 & Kristian F. Lynch3 & Helena Elding Larsson4,5 & Åke Lernmark5,6 & Marian J. Rewers7 & Carina Törn4,5 & Brant R. Burkhardt3 & Thomas Briese8,9 & William A. Hagopian10 & Jin-Xiong She11 & Olli G. Simell12,13 & Jorma Toppari14,15 & Anette-G. Ziegler16,17 & Beena

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/74%2010262018_679_74_MP22a_Lonnrot_Diabetologia_2017.pdf - 2026-05-27

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children RESEARCH ARTICLE Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children Ezio Bonifacio1, Andreas Beyerlein2,3,4, Markus Hippich2,3,4, Christiane Winkler2,3,4, Kendra Vehik5, Michael N. Weedon6, Mic

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/88%2010262018_679_88_MP165a_Bonifacio_PLOS%20Med_2018.pdf - 2026-05-27

Voice problems are common among workers in occupations with high demands on oral communication. For sustaining vocal health, it is important to find efficient ways for how to reduce strain on the voice at work, and one way to do so is optimizing the room acoustics for communication. However, to date we do not know enough about what kind of room acoustic conditions that support voice and speech mos

Until today, the performance of a motor vehicle has required the present of a human driver. With a human driver follow human factors. In recent years, more automatic functions have been implemented in new cars and self-driving cars at higher levels have begun to develop. This development limits the influence of the human factors. The purpose is with the thesis project, to investigate which problem

Hjärttransplantationer syftar till att rädda liv men kan även vara riskabla ingrepp. Det är mycket som kan gå fel. Det transplanterade hjärtat lider stor risk att avstötas i mottagarens kropp, och en mer detaljerad kunskap om faktorerna som påverkar avstötning har således möjligheten att rädda liv. Avstötning orsakas av att mottagarens immunförsvar känner av HLA-molekylerna, där HLA står för HumThe beneficial effects of HLA matching at the HLA-A, -B and -DR loci on recipient short- and long-term survival in heart transplants have been established in a number of studies. The objective of the present study was to evaluate the importance of individual HLA alleles at the HLA-A, -B and -DR loci as risk factors for recipient death within one year after transplant by using artificial neural net

Background: Pre-hospital electrocardiogram (ECG) transmission to an expert for interpretation and triage reduces time to acute percutaneous coronary intervention (PCI) in patients with ST elevation Myocardial Infarction (STEMI). In order to detect all STEMI patients, the ECG should be transmitted in all cases of suspected acute cardiac ischemia. The aim of this study was to examine the ability of

This LUii report presents empirical results from studies on consumption and over-indebtedness in Swedish young adults in a digital context. The studies have been conducted through in-depth interviews with municipal financial counsellors as well as a quantitative survey with approximately 1,100 respondents in a sample representative of Swedes from 18 to 25 years old. The report includes an extensiv

Retroperitoneal sarcomas are rare and treatment should optimally be centralized. Despite successful centralization with 90% of the patients referred prior to surgery, delays occur, which led us to assess lead times in a population-based series. Method. Patients diagnosed with retroperitoneal sarcoma in the southern Sweden health care region 2003-2009 were eligible for the study. Data on referrals

PURPOSE: The purpose of this study was to observe sickness absence before and after the cancer diagnosis among cancer patients with five common forms of cancer. METHODS: Using cohort data, we observed sick leave in the pre- and post-diagnostic phase among patients with colon, rectal, breast, prostate, or lung cancer (n = 2,738). We also identified reference subjects without cancer (total n = 12,24

Background: The WHO and the World Bank ask countries to report the national volume of surgery. This report describes these data for Sweden, a high-income country. Methods: In an 8-year population-based observational cohort study, all inpatient and outpatient care in the public and private sectors was detected in the Swedish National Patient Register and screened for the occurrence of surgery. The