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A Compact Chemical Kinetic Mechanism for Heavy Fuel Surrogates with n-, iso- and cyclo-Alkanes, and Aromatic Compounds

Modeling of real-world fuels and fuel mixtures in combustion engines, using computational fluid dynamics (CFD), calls for the development of compact and computationally efficient chemical kinetic mechanisms. To improve the modeling capabilities of multicomponent fuels it is necessary to transition from the single-component descriptions of fuels and move toward more complex, accurate multicomponent

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1 A Measure of Last Resort? The Current Status of Juvenile Justice in ASEAN Member States 2 Country Researchers: BRUNEI DARUSSALAM: Datin Paduka Hajjah Intan bte Haji Mohd Kassim CAMBODIA: Aekje Teeuwen INDONESIA: Indah Amaritasari LAOS: Champathong Phochanthilath MALAYSIA: Shelley Casey MYANMAR: Charlotte Moreau PHILIPPINES: Maria Lourdes Fugoso-Alcain SINGAPORE: Kelsey Lefebvre Ekman THAILAND: K

https://rwi.lu.se/app/uploads/2015/04/Juvenile-Justice-Report.pdf - 2026-05-31

RIKSAVTAL

RIKSAVTAL 1 RIKSAVTAL mellan Svensk Scenkonst och Teaterförbundet samt Akademikerförbunden avseende anställda vid offentligt finansierade teaterinstitutioner 2020.11.01 – 2023.03.31 2 Innehållsförteckning 1 Inledande bestämmelser…………………………………………………………………..5 1.1 Avtalets omfattning .................................................................................................... 5 1.2 Undantag ..

https://www.saco.se/globalassets/lokala-akademikerforeningar/privat/akademikerforbunden-aht/dokument/kollektivavtal/svensk-scenkonst-institutionsteateravtalet-2020-2023.pdf - 2026-05-31

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Lunds universitet HT2023 Språk och litteraturcentrum LIVA15: Barnlitteratur (1–30hp) Delkurs 3: Barnlitteraturens genrer (7,5hp) Fastställd av Sektionsstyrelse 2, Språk- och litteraturcentrum, den 7 juni 2023. Facklitteratur Attebery, Brian (1992), ”Fantasy as Mode, Genre, Formula”, i Strategies of Fantasy, Indiana University Press, s. 1-18 (18s) Basu, Balaka och Katherine R. Broad och Carrie Hint

https://www.sol.lu.se/media/utbildning/dokument/kurser/LIVA15/20232/LIVA15_dk3_HT_2023_Litteraturlista_.pdf - 2026-05-31

A Highly Sensitive Porous Silicon (P-Si)-Based Human Kallikrein 2 (hK2) Immunoassay Platform toward Accurate Diagnosis of Prostate Cancer.

Levels of total human kallikrein 2 (hK2), a protein involved the pathology of prostate cancer (PCa), could be used as a biomarker to aid in the diagnosis of this disease. In this study, we report on a porous silicon antibody immunoassay platform for the detection of serum levels of total hK2. The surface of porous silicon has a 3-dimensional macro- and nanoporous structure, which offers a large bi

The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-side

Emphasizing the role of Wnt5a protein expression to predict favorable outcome after radical prostatectomy in patients with low-grade prostate cancer

Wnt5a, a member of non-canonical wingless-related MMTV integration site family is a secreted glycoprotein that plays important roles in development and disease. Recent studies have shown that Wnt5a protein levels are up-regulated in prostate cancer, but contrasting reports exist on the role of Wnt5a to predict outcome after radical prostatectomy in patients with localized prostate cancer. Our grou

Participation and Independence in Old Age - Aspects of home and neighbourhood environments

Popular Abstract in Swedish Det övergripande syftet med denna avhandling var utforska de allra äldstas upplevelser av delaktighet och självständighet med speciellt fokus på hemmet och närmsta omgivningen. Dagens debatt om åldrandet handlar mestadels om kvaliten i vård och omsorg, dess kostnader men också om bristande omsorg. Även boendefrågor debatteras, men då är det oftast bristen på s k särskiThe current trend in Sweden is to support older people to remain living in their own homes as long as possible. Older people spend much of their daily life within the home and neighbourhood environment. It is well known that participation and independence is important in experiencing well being in old age. Thus from a health-promotion perspective it is interesting to uncover aspects within the hom

Tumor markers in prostate cancer I: Blood-based markers

The introduction of total prostate specific antigen (total PSA) testing in blood has revolutionized the detection and management of men with prostate cancer (PCa). The objective of this review was to discuss the challenges of PCa biomarker research, definition of the type of PCa biomarkers, the statistical considerations for biomarker discovery and validation, and to review the literature regardin

The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer.

Signal transducer and activator of transcription 3 (STAT3) is known to be involved in the progression of prostate cancer (PCa) and is a key factor in drug resistance and tumor immunoescape. As a result, it represents a promising target for PCa therapy. We studied the effects of the STAT3 inhibitor galiellalactone (GL) on tumor growth and metastatic spread in vitro and in vivo. The effect of GL on

Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma.

The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres. Following the recent finding in familial melanoma of inactivating germline mutations in POT1, encoding a member of the shelterin complex, we searched for mutations in the other five components of the shelterin complex in melanoma families.

Acoustofluidic, label-free separation and simultaneous concentration of rare tumor cells from white blood cells

Enrichment of rare cells from peripheral blood has emerged as a means to enable noninvasive diagnostics and development of personalized drugs, commonly associated with a prerequisite to concentrate the enriched rare cell population prior to molecular analysis or culture. However, common concentration by centrifugation has important limitations when processing low cell numbers. Here, we report on a

A Compartmental Model for Biokinetics and Dosimetry of 18F-Choline in Prostate Cancer Patients

PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentration

t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma

Purpose The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precurso

Diversity of human papillomaviruses in skin lesions.

Pools of frozen biopsies from patients with squamous cell carcinoma (SCC) (n=29) actinic keratosis (AK) (n=31), keratoacanthoma (n=91) and swab samples from 84 SCCs and 91 AKs were analysed with an extended HPV general primer PCR and high-throughput sequencing of amplimers. We found 273 different HPV isolates (87 known HPV types, 139 previously known HPV sequences (putative types) and 47 sequences

Genetic Variation in KLK2 and KLK3 Is Associated with Concentrations of hK2 and PSA in Serum and Seminal Plasma in Young Men

BACKGROUND: Genetic variants in KLK2 and KLK3 have been associated with increased serum concentrations of their encoded proteins, human kallikrein-related peptidase 2 (hK2) and prostate-specific antigen (PSA), and with prostate cancer in older men. Low PSA concentrations in seminal plasma (SP) have been associated with low sperm motility. To evaluate whether KLK2 and KLK3 genetic variants affect p

Serum markers in prostate cancer detection.

Prostate-specific antigen (PSA) testing provides significant benefits by reducing prostate cancer mortality, but also leads to important harms by detecting clinically insignificant cancers. Hence, there are urgent needs for complementary tools for middle-aged men with modest PSA elevations in blood. This review includes research on prostate cancer biomarkers in blood published from March 2013 thro

Biokinetics Of 18F-Choline Studied In Four Prostate Cancer Patients

Biokinetic data are important when calculating the absorbed dose to the patients and can also be used to find the optimal time between injection and imaging. To the authors' knowledge, there are no published biokinetic data in humans for (18)F-choline, except some distribution data at single time points. Four patients with suspicion of metastases due to biochemical recurrence (measurable prostate-

Serum levels of vitamin D, parathyroid hormone and calcium in relation to survival following breast cancer.

Vitamin D, parathyroid hormone (PTH) and calcium in blood are correlated with each other. Previous studies have suggested vitamin D to have anti-proliferative effects on tumor cells, whereas PTH may have carcinogenic effects. A cancer disease may influence calcium levels in blood, but less is known about calcium and its potential effect on cancer risk and survival. The aim of this study was to exa

The fungal metabolite galiellalactone interferes with the nuclear import of NF-κB and inhibits HIV-1 replication.

Galiellalactone (GL) is a metabolite produced by the fungus Galiella rufa that presents antitumor and immunomodulatory activities. GL interferes with the binding to DNA of signal transducer and activator of transcription (STAT)-3 and also inhibits other signal pathways such as NF-κB, but the mechanism of action in this pathway remains unknown. In this study we report that GL inhibits vesicular sto