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Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern : an observational study

BACKGROUND: To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal COVID-19 among nursing homes residents.METHODS: We performed repeated capillary blood sampling with analysis of S-binding IgG in an open cohort of nursing home residents in Sweden. We analyzed immunological and registry data from 16

Monte Carlo Simulations and Validation of NectarCAM, a Medium Sized Telescope Camera for CTA

The upcoming Cherenkov Telescope Array (CTA) ground-based gamma-ray observatory will open up our view of the very high energy Universe, offering an improvement in sensitivity of 5-10 times that of previous experiments. NectarCAM is one of the proposed cameras for the Medium-Sized Telescopes (MST) which have been designed to cover the core energy range of CTA, from 100 GeV to 10 TeV. The final came

Application of pattern spectra and convolutional neural networks to the analysis of simulated Cherenkov Telescope Array data

The Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory and will be the major global instrument for very-high-energy astronomy over the next decade, offering 5 − 10 × better flux sensitivity than current generation gamma-ray telescopes. Each telescope will provide a snapshot of gamma-ray induced particle showers by capturing the induced Cherenkov emission at ground le

Acoustophoresis for label-free separation and concentration of cancer cells

Here, an acoustophoresis chip is presented that is capable of separating cancer cells from white blood cells (WBCs) and subsequently concentrating the recovered cells in the same chip. The chip utilizes ultrasound standing waves in two dimensions to pre-align, separate and concentrate the cells. 92% of the cancer cells could be recovered while keeping the contamination level of WBCs to only 0.6%.

Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations

The risk of pancreatic cancer (PC) is increased in melanoma-prone families but the causal relationship between germline CDKN2A mutations and PC risk is uncertain, suggesting the existence of non-CDKN2A factors. One genetic possibility involves patients having mutations in multiple high-risk PC-related genes; however, no systematic examination has yet been conducted. We used next-generation sequenc

Expanding the genotype–phenotype spectrum in hereditary colorectal cancer by gene panel testing

Hereditary syndromes causing colorectal cancer include both polyposis and non-polyposis syndromes. Overlapping phenotypes between the syndromes have been recognized and this make targeted molecular testing for single genes less favorable, instead there is a gaining interest for multi-gene panel-based approaches detecting both SNVs, indels and CNVs in the same assay. We applied a panel including 19

ORF-MOSAIC for Adaptive Control of a Biomimetic Arm

This study is an attempt to take advantage of a cerebellar model to control a biomimetic arm. The cerebellar controller is a modified MOSAIC model which adaptively controls the arm. We call this model ORF-MOSAIC (Organized by Receptive Fields MOdular Selection And Identification for Control). The arm features a musculoskeletal model which is controlled through muscle activations by means of optimi

The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus

Long-distance migratory animals such as birds and bats have evolved to withstand selection imposed by pathogens across the globe, and pathogen richness is known to be particularly high in tropical regions. Immune genes, so-called Major Histocompatibility Complex (MHC) genes, are highly duplicated in songbirds compared to other vertebrates, and this high MHC diversity has been hypothesised to resul

The clinicopathological and gene expression patterns associated with ulceration of primary melanoma

Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict benefit from adjuvant interferon. To better understand the biological processes involved, clinicopathological factors associated with ulceration were determined in 1804 patients. From this cohort, 348 primary tumor blocks were sampled to generate gene expression data using a 502-gene cancer panel and 195 b

Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study

Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the rat

Dietary intake of acrylamide and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Acrylamide, classified in 1994 by IARC as 'probably carcinogenic' to humans, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. The association between dietary acrylamide intake and epithelial ovarian cancer risk (EOC) has been previously studied in one case-control and three prospective cohort studies which obtained inconsistent results, and could not further examine histologic

Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender.

Introduction: Many studies over recent decades report an increasing incidence of lung cancer in female patients. Female gender is often reported as a good prognostic factor. Objectives: The aim of the present study was to investigate prognostic factors with a special emphasis on gender. Methods: During 1989-2008, 1497 patients in eastern Scania, a part of southern Sweden with 202 000 inhabitan

The role of public relations practitioners in the reputation management of CEOs - Results of a shadowing study

This paper combines theory and data collected from a shadowing study to explore the role of communication and public relations practitioners in reputation management. In seeking to explore the role communication managers have on the reputation of a CEO and the corporate reputation, this study builds on the existing research on roles research and corporate reputation. The theoretical framework conn

Brian Burdekin Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law

Brian Burdekin Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Work M

https://rwi.lu.se/tag/brian-burdekin/ - 2026-05-31

Poor self-rated health in individuals with irritable bowel syndrome but no increased 10-year cardiovascular risk : results from a Swedish population-based screening program

Introduction: Irritable bowel syndrome (IBS) has been linked to poor health, high stress and diminished quality of life. Previous findings about associations between IBS and cardiovascular disease are, however, contradictory. Our objective was to examine 10-year cardiovascular risk, lifestyle factors, and self-rated health in people with IBS compared to a reference group. Methods: Sweden's souther

Literary exploration as a resource for professional development : Junior doctors’ experiences of shared reading

Studies have shown positive health outcomes from shared reading (SR) for various patient groups. In this article, we explore whether this applies to doctors as well by studying the dynamics of SR sessions and a subsequent participant focus group. Four SR sessions, with one short story and one or two poems each, were held with medical interns working at Skåne University Hospital, Sweden. A reflexiv