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Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have
Objective: The objective of this study was to pool, harmonise and re-analyse national accelerometer data from adults in four European countries in order to describe population levels of sedentary time and physical inactivity. Methods: Five cross-sectional studies were included from England, Portugal, Norway and Sweden. ActiGraph accelerometer count data were centrally processed using the same algo
Purpose: The purpose of this study was to explore the relationship between oxidative stress, antioxidant defense, mitochondrial structure, and biomechanical tissue support in the isolated porcine retina.Methods: Full-thickness retinal sheets were isolated from adult porcine eyes. Retinas were cultured for 2 or 48 h using (1) a previously established low-support explant protocol with photoreceptors
Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a potential treatment for retinal degenerative disorders. Here we report that the suppression of ERG responses is attributable to negative regulation of t
SenseWear Armband (SW) is a multisensor monitor to assess physical activity and energy expenditure. Its prediction algorithms have been updated periodically. The aim was to validate SW in children, adolescents, and adults. The most recent SW algorithm 5.2 (SW5.2) and the previous version 2.2 (SW2.2) were evaluated for estimation of energy expenditure during semi-structured activities in 35 childre
The search for new cancer biomarkers is essential for fundamental research, diagnostics, as well as for patient treatment and monitoring. Whereas most cancer biomarkers are biomolecules, an increasing number of studies show that mechanical cues are promising biomarker candidates. Although cell deformability has been shown to be a possible cancer biomarker, cellular forces as cancer biomarkers have
This article examines the environmental management of Stockholm's large brownfield development Hammarby Sjöstad through the concept of negotiating sustainabilities. An Environmental Programme injected exceptional aims into an ongoing, ordinary planning process involving developers, consultants, contractors and other stakeholders. In parallel, a project team was established and given the task of re
In times of climate change political goals concern a reduction in total energy consumption and to use energy more efficiently. To achieve this, users need to transform their behaviour and start reflecting on their energy use. This paper discusses three different methods for visualising energy use, namely information tools, keeping time-diaries and using the 'Power-Aware Cord'. Each method has its
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals
Several monogenic causes of familial myelodysplastic syndrome (MDS) have recently been identified. We studied two families with cytopenia, predisposition to MDS with chromosome 7 aberrations, immunodeficiency, and progressive cerebellar dysfunction. Genetic studies uncovered heterozygous missense mutations in SAMD9L, a tumor suppressor gene located on chromosome arm 7q. Consistent with a gain-of-f
Universitetslektor Kontaktinformation E-post: karol [dot] nowak [at] jur [dot] lu [dot] se Telefon: +46 46 222 12 35Organisation Juridiska institutionen Rumsnummer: 329 Hämtställe: 56 WebbplatsKarol Nowaks profil i Lunds universitets forskningsportalAndra roller Forskare Mänskliga rättigheter Forskare Folkrätt Affilierad forskare Centrum för beredskap och resiliens (LUPREP) Publikationer Visar av
https://www.jur.lu.se/karol-nowak - 2026-04-30
Docent Socionom, genusvetare samt FD och docent i socialt arbete. Utsedd till exellent lärare. Kontaktinformation E-post: tina [dot] mattsson [at] soch [dot] lu [dot] se Telefon: +46 46 222 12 53Organisation Socialhögskolan Rumsnummer: 418 Hämtställe: 28 WebbplatsTina Mattssons profil i Lunds universitets forskningsportalAndra roller Universitetslektor Socialhögskolan Skyddsombud Socialhögskolan U
https://www.soch.lu.se/tina-mattsson - 2026-04-30
PURPOSE: Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, especially using large cohorts. Thus, we sought to identify the intrinsic molecular subtypes of mCRPC and assess molecular and clinical correlates in the largest combined cohort
The Late Pleistocene cataclysmic releases of glacial meltwater left distinct footprint across the Central European Lowland. Deeply incised tunnel valleys, oversized ice-marginal spillways, fields of mega-dunes, and glacial curvilineations carved by rapid drainage events occur along the southern margin of the last (Weichselian) Scandinavian Ice Sheet margin. These meltwater releases contributed sigThe Late Pleistocene cataclysmic releases of glacial meltwater left distinct footprint across the Central European Lowland. Deeply incised tunnel valleys, oversized ice-marginal spillways, fields of mega-dunes, and glacial curvilineations carved by rapid drainage events occur along the southern margin of the last (Weichselian) Scandinavian Ice Sheet margin. These meltwater releases contributed sig
Introduction: Evidence for gut–kidney interactions in early kidney disease is limited, particularly in community-dwelling adults with largely preserved kidney function. Here, we quantified links between gut microbiota and estimated glomerular filtration rate (eGFR) in two population-based Swedish cohorts. Methods: Deep shotgun metagenomics profiled fecal samples from 9788 adults in the Swedish CAr
Health Law – en ny forskningsmiljö om rätten i vården veckling och en högkvalitativ vård- och omsorgsverksamhet i Sveri- ge och i Europa. Ett exempel är den snabbt växande utvecklingen inom e-hälsa. Det finns e tt betydande intresse hos kommuner, myndigheter och företag för denna utveckling och ofta även en tillmötesgående attityd till förändrade förutsättningar för patienter och brukare. Dessvärr
Microsoft Word - Kaela final draft 1 LUND UNIVERSITY INTERNATIONAL MASTER’S PROGRAMME IN ENVIRONMENTAL STUDIES AND SUSTAINABILITY SCIENCE An Assessment of the Economic, Social and Environmental Impacts of the Mining Industry A Case Study of Copper Mining in Zambia AUTHOR: SUPERVISOR: Priscilla Kaela Kangwa Dr Ransom Lekunze, Copperbelt Museum Department of Social and Economic Geography Buteko Aven
https://www.lumes.lu.se/sites/lumes.lu.se/files/kaela_kangwa.pdf - 2026-04-30
