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In two recent double-blind clinical trials of fetal ventral mesencephalic cell transplants into the striatum in patients with Parkinson's disease (PD), a significant proportion of the grafted patients developed dyskinetic side effects, which were not seen in the sham operated patients. Comparison between dyskinetic and non-dyskinetic grafted patients in one of the trials suggested that an uneven p
Previously genome-wide association methods in patients with classic bladder exstrophy (CBE) found association with ISL1, a master control gene expressed in pericloacal mesenchyme. This study sought to further explore the genetics in a larger set of patients following-up on the most promising genomic regions previously reported. Genotypes of 12 markers obtained from 268 CBE patients of Australian,
Extracellular signal-regulated kinase 2 (ERK2) is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. Passive transport of an ERK2 monomer through the nuclear pore is also reported to coexist. We attempted to characterize the cytoplasmic retention and nuclear translocation of fusion proteins between deletion and sit
The extent to which humans help each other is extraordinary in itself, and difficult to explain from an evolutionary perspective. Therefore, there has been a recent surge in studies investigating the evolution of prosocial behavior using a comparative approach. Nevertheless, most of these studies have focused on primates only, and little is known about other animal orders. In a previous study, com
Summary: The study investigates the effect of physical activity (PA) on a composite score for fracture risk in pre-pubertal children. Low PA in children is related to the composite score for fracture risk and the pre-pubertal years seem to be a period when PA positively affects the score. Introduction: This study evaluates if PA in children is related to clustering of risk factors for fracture. Re
NMD3 is required for nuclear export of the 60S ribosomal subunit in yeast and vertebrate cells, but no corresponding function of NMD3 has been reported in plants. Here we report that Arabidopsis thaliana NMD3 (AtNMD3) showed a similar function in the nuclear export of the 60S ribosomal subunit. Interference with AtNMD3 function by overexpressing a truncated dominant negative form of the protein la
Recent studies indicate a crucial role for neuronal glycogen storage and degradation in memory formation. We have previously identified alpha-amylase (α-amylase), a glycogen degradation enzyme, located within synaptic-like structures in CA1 pyramidal neurons and shown that individuals with a high copy number variation of α-amylase perform better on the episodic memory test. We reported that neuron
In the philosophy of J. L. Schellenberg, “evolutionary religion” is a religious stance oriented towards the deep future. According to Schellenberg, the best form of evolutionary religion is non-doxastic faith in ultimism. I reject Schellenberg’s arguments for preferring ultimism and suggest that committing non-doxastically to traditional religion makes more sense from an evolutionary perspective.
Study Design: Prospective register cohort study. Objectives: The indication for surgery in patients with lumbar spinal stenosis (LSS) is considered to be leg pain and neurogenic claudication (NC). Nevertheless, a significant part of patients operated for LSS have mild leg pain levels defined as leg pain ≤minimally important clinical difference (MICD). Information is lacking on how to inform these
Staphylococcal toxic shock syndrome is a potentially lethal illness attributed to superantigens produced by Staphylococcus aureus, in particular toxic shock syndrome toxin 1 (TSST-1), but staphylococcal enterotoxins (SEs) are also implicated. The genes encoding these important toxins are carried on mobile genetic elements, and the regulatory networks controlling expression of these toxins remain r
Erlotinib inhibits epithelial growth factor receptor (EGFR) kinase activity and is used to treat non-small cell lung cancer (NSCLC). Despite its high efficacy, recurrence can occur in patients who become resistant to the drug. To address the underlying mechanism of Erlotinib resistance, we investigated additional mechanisms related to mode-of-drug-action, by multiple protein-binding interactions,
BACKGROUND: Aortic dissection type A requires immediate surgery. In general surgery populations, patients operated during weekends have higher mortality rates compared to patients operated on weekdays. The weekend effect in aortic dissection type A has not been studied in detail.METHODS: The Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD) registry includes patients (N=1,159) who und
C4b-binding protein (C4BP) regulates the classical pathway C3-convertase of the complement system. Human C4BP is composed of seven identical subunits (alpha-chains) and one unique one (beta-chain). Both types of chains contain homologous repeats called complement control proteins (CCPs); the alpha-chain contains eight CCPs and the beta-chain three. Each alpha-chain contains a binding site for C4b
This study investigates the link between the personality profiles and socio-demographic characteristics of wine consumers and the sensory characteristics of the wines they prefer. This was measured in terms of a self-reported list of the wines they like and buy. The 1176 Italian adults who participated were asked to complete an online form. Information was collected regarding certain socio-demogra
an-European research infrastructures (RIs) have been labelled a ‘pillar’ of the European Research Area initiative and ‘engines’ which are expected to drive forward the European Union (EU) economy by advancing its science and technology and ultimately its competitiveness on the global arena. The focus of this article is on the origins and nature of a policy tool named the European Research Infrastr
Arachidonic acid (AA) functions as a structural component, eicosanoid precursor and surface material for chylomicron production in the gastrointestinal tract. The origin of this AA is poorly characterized. [3H]AA labelled chylomicrons and [14C]AA albumin-FFA were injected intravenously into biliary diverted rats and controls. Radioactivity in tissue lipids was measured after different time interva
