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Popular Abstract in Swedish Ökad förståelse för hjärtats pumpfunktion är av stort intresse för att kunna förbättra diagnostik, behandling och prognoser för hjärtsjuka patienter. Blodflöde i hjärtat är direkt kopplat till hjärtats form och rörelse och kan därför vara en viktig markör för hjärtats funktion. Därför var målet med denna avhandling att utveckla och förbättra mätningar av blodflöde med hIncreased understanding of the pumping mechanics of the heart are of great importance to develop diagnostics, treatment and prognostics for cardiovascular diseases. Blood flow in the heart is connected to its anatomy and function, and may therefore be a sensitive marker of cardiac health and disease. Therefore, the aim of this thesis is to develop and validate methods for quantification and visual

Popular Abstract in Swedish Proteoglykaner (PG), framför allt sådana som bär glykosaminoglykan-sidokedjor av heparansulfat (HS) typ, utgör multifunktionella receptorer på cellytan och i pericellulär matrix hos alla adherenta celler i högre organismer. HS-proteoglykaner är inblandade i många olika cellprocesser, bl.a. koagulation, celltillväxt, och aktivering av enzymer, antienzymer samt bindning t

Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness o

To study global nitrogen (N) leaching from natural ecosystems under changing N deposition, climate, and atmospheric CO2, we performed a factorial model experiment for the period 1901-2006 with the N-enabled global terrestrial ecosystem model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator). In eight global simulations, we used either the true transient time series of N deposition, climate

The main functions of estrogen are associated with reproduction. However, estrogen has been shown to be of functional importance also in non-classic target organs. Previous studies, especially epidemiologic and clinical ones, have addressed estrogen's influence on periodontitis, suggesting that estrogen has a beneficial effect, but the biological mechanisms have not been identified. Estrogen exert

Globally, the food and energy demands of the growing global population are rising and require increased agricultural production. Additionally, climate change will have adverse effects on agricultural productivity. Technological change can contribute to closing yield gaps and reducing post-harvest losses, but needs to be facilitated through investments and education. Considering the multiple driver

The world as we know it today has evolved to be a very connected space, where not only ICT’s (information & communication technologies) have made it easy to interact with individuals around the globe at any time, but also developments in air travel allow to reach ever more distant destinations. Many go as far as describing the world as shrinking or small; it seems that at least it feels smalle

Det finns i detta nu en pågående debatt inom den offentliga upphandlingen kring huruvida det är en för samhället positiv sak att i samband med upphandlingsprocessen ställa krav på att leverantören lever upp till vissa sociala åtaganden. De senaste årens utveckling har resulterat i att EU i allt större utsträckning uppmuntrar upphandlande myndigheter att använda sig av sociala hänsyn i sina upphand

The theoretical focus in this master is information retrieval (IR), and especially the part of IR that includes interactivity. This research is by some researchers called IIR. Our principal aim was to examine if search engines on the WWW are taking advantage of research results from IIR research. A way to do this is to look at the application of special features, in this case query expansion (QE)

Public procurement - which can shortly be explained with the government's activity of purchasing goods and services - presents one of the largest economic markets in the world, accounting, on average, for 15 per cent of the gross national product (GDP) worldwide. One of the most controversially debated issues regarding public procurement is that of procurement linkages. The questions evolve ar

The realisation of the inner market meant that all border controls between the Member States of the European Community were to disappear, so that the four freedoms, workers, capital, services and goods, could cross the borders without problems. But in order to keep the security in a Community with no borders, the external border controls had to be strengthened. This was necessary to keep out drugs

1. The massive growth of large, toxic cyanobacteria in eutrophic waters has traditionally been explained by their evolution of defences to herbivorous zooplankton. These conclusions come mostly from studies using the large-bodied cladoceran Daphnia as a grazer model. In contrast, very little is known about the effects of other zooplankters such as copepods and small cladocerans that, unlike Daphni

Background: Array comparative genomic hybridization (aCGH) is commonly used to screen different types of genetic variation in humans and model species. Here, we performed aCGH using an oligonucleotide gene-expression array for a non-model species, the intertidal snail Littorina saxatilis. First, we tested what types of genetic variation can be detected by this method using direct re-sequencing and

Denna uppsats baserar sig på en utredning av Försäkringskassan, som presenterades i maj 2005. Titeln var Utredning om könsneutralt och delat barnbidrag. Försäkringskassan hade fått i uppdrag av regeringen att utreda förutsättningarna för att göra lagstiftningen kring barnbidraget könsneutral och införa en möjlighet för föräldrarna att kunna dela bidraget mellan sig. Den nuvarande barnbidragslagsti

Continuous water-table (WT) measurements from peatlands are scarce and – if existing at all –very short. Consequently, proxy indicators are critically needed to simulate hydrological changes in peatlands over longer time periods. In this study, we demonstrate that tree-ring width (TRW) records of Scots pine (Pinus sylvestris L.) growing in the Čepkeliai peatland (southern Lithuania) can be used as

Aim/hypothesis: Human enteroviral infections are suggested to be associated with type 1 diabetes. However, the mechanism by which enteroviruses can trigger disease remains unknown. The present study aims to investigate the impact of enterovirus on autophagy, a cellular process that regulates beta cell homeostasis, using the clonal beta cell line INS(832/13) and human islet cells as in vitro models

Background: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 and 18 months after treatment initiation. Methods: ORBIT (online remote behavioural intervention for tics) was a two-arm (1:1 ratio), superiority, sing

Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this study, we investigated the therapeutic potential of MCC950, a specific, small-molecule inhibitor of

Background: Although many people infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) experience no or mild symptoms, some individuals can develop severe illness and may die, particularly older people and those with underlying medical problems. Providing evidence-based interventions to prevent SARS-CoV-2 infection has become more urgent with the potential psychological toll i