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Cytostatika är läkemedel som används för att behandla cancer genom att hämma eller stoppa celldelning. De används även som immunhämmande medel, till exempel vid organtransplantationer och autoimmuna sjukdomar. Eftersom dessa läkemedel påverkar cellers tillväxt kan de vara skadliga även i mycket små mängder om de hamnar i miljön. Cytostatika har upptäckts i ytvatten, grundvatten och dricksvatten i Introduction: Cytostatic pharmaceuticals are increasingly detected in the aquatic environment, raising concerns due to their persistence and toxicity. Background: Conventional wastewater treatment processes do not effectively remove these compounds. Advanced oxidation processes, such as ozonation, are needed to degrade cytostatic pharmaceuticals during wastewater treatment. However, these process

The aim of this research project was to create a bioinformatic image analysis pipeline for the investigation of lymphocytes in healthy human lungs. The lung is an important organ to study as it provides a fast way for pathogens to enter the body. Therefore, the pulmonary immune system must be further investigated in both healthy and diseased tissue. In order to do comparative studies, we need to c

The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage

As the greenhouse gas emissions keep on increasing the need for solutions to help reduce emissions across all sectors has never been greater. The European Union has pointed out green hydrogen as a step in increasing the sustainability of the energy sector in Europe. Goals has been set to boost the development of hydrogen technology since the green hydrogen production today is only existing in an i

The study examines the narratives of the Decembrist revolt created in and around Russian state-funded cinema. By exploring the narratives surrounding a particular instance of political dissent in the past, the research seeks to uncover the factors that impact on the negotiation of cultural memory between the text and the audience in the context of state-influenced media. This exploration is based

Populärvetenskaplig sammanfattning: Utvärdering av borrhålsloggar. Syftet med detta examensarbete var att göra en utvärdering av wireline borrhålsloggar från borrhålet Kyrkheddinge-4, 3 km öster om Staffanstorp i Skåne. Den undersökta delen av borrhålet Kyrkheddinge-4 befinner sig inom den potentiella reservoarsandstenen, Lundasandstenen. Wireline borrhålsloggar är geofysiska verktyg som används This study is an evaluation of formation characteristics, as derived from wire-line well logs, of the Lund Member in the borehole Kyrkheddinge-4, 3 km east of Staffanstorp, Skåne, Sweden, through the comparison to measured core data. The purpose is to assess the feasibility of using some of the porosity and permeability equations and cross-plots derived for the investigated section and applying th

Previous studies have found that launch prices reflect the therapeutic gains of pharmaceuticals (for instance: Ekelund and Persson, 2003, on Sweden and Lu and Comanor, 1998, on the US). Furthermore, Howard et al (2015) found that purely pharmaceutical costs to “Medicare” at launch for new anticancer drugs increased annually, from 1995-2013, after controlling for health benefits and inflation. This

In this master thesis, the topic of energy storage connected to concentrator photovoltaic power production is assessed. The end goal is to propose the optimal energy storage technology and its sizing, regarding power and energy capacity, for an existing concentrator photovoltaic power plant. The plant is located in the province of Algarve in Portugal, the installed production capacity is 4.5 MW, a

Purpose: This study aimed to investigate the factors associated with blood pressure control in a primary healthcare population with hypertension. Materials and methods: We used baseline data from a recent Swedish randomized controlled trial where 400 patients diagnosed with hypertension from 10 primary health care centers were included. The participants underwent blood pressure measurements, blood

We evaluated the association between cardiopulmonary bypass (CPB) time during surgery for acute type A aortic dissection (ATAAD) and mid-term survival. Data of 1122 patients who underwent surgery for ATAAD in eight Nordic centers from January 2005 to December 2014 were retrospectively analyzed. An adjusted logistic regression analysis was performed to investigate the association of incremental 30

Background: Dissecting free tissue flaps can be challenging and time-consuming. Imaging technologies are typically used to assist with preoperative planning. However, conventional methods have limitations that could potentially be overcome by extended reality technologies. This systematic review aimed to evaluate the current use of extended reality (XR) in preoperative planning for microsurgical f

Background: Portal vein embolization (PVE) may be used to induce hypertrophy of the future liver remnant (FLR) before major hepatectomy. The influence of hyperbilirubinemia on FLR hypertrophy after PVE is controversial. The aim of this study was to compare FLR hypertrophy after PVE between patients with and without elevated P-bilirubin. Materials/methods: This is a Scandinavian retrospective cohor

Background: Tattoo inks are mixtures of organic and inorganic color pigments and having a tattoo may be adversely associated with biomarkers of male fecundity. Objective: To examine the association between tattoo exposure and biomarkers of male fecundity. Methods: Participants were young adult Danish males (aged 18–21 years) sampled from the Danish National Birth Cohort. Upon recruitment in 2017–2

BACKGROUND: Many poly- and perfluoroalkyl substances (PFAS) are persistent and have long half-lives in the human body. However, there are limited data on the different routes of elimination. Most pharmacokinetic models assume that the urinary route dominates.OBJECTIVES: Our aim was to investigate the relative importance of fecal and urinary elimination for linear perfluorooctane sulfonic acid (L-P

The study examines the narratives of the Decembrist revolt created in and around Russian state-funded cinema. By exploring the narratives surrounding a particular instance of political dissent in the past, the research seeks to uncover the factors that impact on the negotiation of cultural memory between the text and the audience in the context of state-influenced media. This exploration is based

OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade

Many women are occupationally active during pregnancy. The aim of this study was to investigate associations between exposure to chemicals during pregnancy and the risk of gestational diabetes or preeclampsia. The cohort included singleton births in Sweden between 1994 and 2014. The cohort was limited to low-educated mothers to reduce potential confounding from unidentified life-style associated f