Filetype
Disinhibition of the mechanistic target of rapamycin (mTOR) pathway has been observed in patients with loss-of-function variants in the disheveled, Egl-10, and pleckstrin domain-containing protein 5 (DEPDC5), and nitrogen permease regulator-like proteins 2 and 3 (NPRL2, and NPRL3) genes, which encode the components of GTPase activating protein Activity Toward Rags Complex 1 (GATOR1) complex. Evero
IntroductionWhile smoking has been consistently identified as a significant contributor to postoperative complications, the existing literature on its association with postoperative pulmonary complications remains conflicting.AimWe examined the association of preoperative smoking with the occurrence of postoperative pulmonary complications (PPCs).MethodsPost hoc analysis of an observational study
BackgroundPreliminary results from the SNAP trial presented at ESCMID Global 2025 reported a high incidence (19.8%) of acute kidney injury (AKI) in patients treated with (flu)cloxacillin for Staphylococcus aureus bacteraemia (SAB).ObjectiveIn Sweden, cloxacillin is used at lower daily doses, and the risk of nephrotoxicity has not been assessed in this setting.MethodsWe retrospectively evaluated re
Background Inversions involving intron 22 (Inv22) of the F8 gene are detected in approximately 45% of all severe hemophilia A (HA) patients. Digital droplet polymerase chain reaction using milepost assays and multiplex ligation-dependent probe amplification (MLPA) allows robust diagnosis of inversions, copy number variations, and more complex rearrangements in F8 . Objectives A total of 350 HA pat
Background: The Peritoneal Cancer Index recorded at laparotomy is based on visual and palpable inspection of peritoneal surfaces for disease. This study aimed to analyze interobserver variation in assigning the lesion score (LS) and morphologic term (MT) to characterize peritoneal lesions (PL) and predict the probability of malignancy (POM) among surgeons with expertise in cytoreductive surgery (C
Background The aim of this systematic review and meta-analysis was to examine autoantibody positive individuals and define: (a) the relative risk of rheumatoid arthritis (RA) compared with autoantibody negative individuals and (b) the cumulative incidence of RA over time, in different populations. Methods A systematic literature search was performed in August 2025. Retrospective case control studi
Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co
Breastfeeding confers a wide range of benefits to mothers and children, and in many contextsmay continue for several years after the birth of a child. As a result, breastfeeding duringpregnancy (BDP) is a common occurrence throughout low- and middle-income countries.Nevertheless, yet there has been little research into its association with the health of breastfedchildren or the outcomes of the pre
Background Multimorbidity, the co-occurrence of two or more non-communicable diseases (NCDs), is common and has been linked to venous thromboembolism (VTE). Whether multimorbidity diagnosed in primary-care is associated with incident VTE remains unclear. We aimed to examine this association. Methods Multimorbidity was defined using Swedish primary-care data. Individuals without prior VTE were incl
To examine longitudinal trajectories of pain occurrence in children with cerebral palsy (CP) aged 1 year to 17 years.A longitudinal register-based study was conducted using data from the Swedish Cerebral Palsy Follow-up Program (2007-2023). Individuals (n = 4887) with confirmed CP, a minimum of three pain assessments, and any Gross Motor Function Classification System (GMFCS) levels were included
India's buildings sector accounts for 41% of national electricity consumption, yet studies incorporating calibrated whole-building energy simulation with thermal comfort evaluation of manufacturing facilities to reduce the industry’s electricity consumption remain scarce, leaving designers without evidence to prioritise passive strategies for this building typology. This study characterises th
Smoking is a well-established risk factor for cardiovascular disease. Studies have indicated that smoking may outweigh the benefit of blood pressure (BP) control. Our aim was to compare cardiovascular risk factors in smokers vs non-smokers from a national sample of treated hypertensives. Data were collected on smoking habits, BP control, total and low-density lipoprotein (LDL) cholesterol, diabete
Between January 1993 - December 1995, the Galileo spacecraft traversed the interplanetary space between Earth and Jupiter and arrived at Jupiter on 7 December 1995. The dust instrument onboard the spacecraft was operating during most of the time and data from the instrument were obtained via memory readouts which occurred at rates between twice per day and once per week. All events were classified
Background: Intrauterine growth restriction (IUGR) is associated with perinatal mortality and with neurologic damage from intraventricular hemorrhage (IVH). We investigated whether S100B, a neural protein found in high concentrations after cell injury in the nervous system, is increased in serum of women whose pregnancies are complicated by IUGR and whose newborns develop IVH. We also explored the
Objective Short bowel syndrome patients frequently experience impaired health-related quality of life. This syndrome is also associated with increased costs for the individuals concerned and the community. Intake of specially processed cereals has been demonstrated to decrease intestinal secretion. This study evaluates the effect of a supplementary diet with specially processed cereals compared wi
OBJECTIVE: Prostate cancer cells secrete the unique protease human glandular kallikrein 2 (hK2) that represents a target for proteolytic activation of cytotoxic prodrugs. The objective of this study was to identify hK2-selective peptide substrates that could be coupled to a cytotoxic analogue of thapsigargin, a potent inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase pump that ind
Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin expression in the subepithelial basement membrane in endobronchial biopsy specimens of the proximal airways from 40 elite, competitive skiers (mean: 17.5; range: 16 to 20 yr) without a diagnosis of asthm
Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN
