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Identification of the perivascular compartment as the point of exchange between cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named the glymphatic system, has emerged as an important clearance pathway for neurotoxic peptides such as amyloid-beta. However, the foundational science of the glymphatic system is based on rodent studies. Here we investigated w
Direct ground cooling is a method for cooling buildings whereby free cooling is provided by circulating water through borehole heat exchangers (BHEs). Since no refrigeration cooling is involved, supply water temperature to the building's cooling system is dependent mainly on BHE sizing. This study investigates the sizing of BHEs for direct ground cooling systems, with a particular focus on the inf
This case study investigates the potentials, greenhouse gas (GHG), and energy performance of forest residue biofuels produced by new and emerging production technologies, which are commercially implemented in Sweden for heavy transport. The biofuel options included are ethanol (ED 95), hydro-processed vegetable oil (HVO), and liquefied biogas (LBG) produced from logging residues in forestry and sa
Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 partic
Social desirability may cause spurious relations in self-rating measures. The present study sought to disentangle socially desirable responding and content in the relation between measures of personality traits and well-being. Social desirability was operationalized as the evaluative factor (the tendency to react to evaluative content in questionnaire items). We collected self- and peer-ratings of
The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This revie
The deactivation of a diesel SCR (Selective Catalytic Reduction) catalyst by impregnation with CaSO4 was studied. The loss in activity after 2729 h of use on the engine was lower than when deactivated by impregnation. This was the case even if the amount of Ca in the catalyst was high after use on the engine. In the used catalyst a surface layer of CaSO4 was built up on the monolith during use. Th
A search for highly ionizing particles produced in proton-proton collisions at 8 TeV center-of-mass energy is performed by the ATLAS Collaboration at the CERN Large Hadron Collider. The data set used corresponds to an integrated luminosity of 7.0 fb-1. A customized trigger significantly increases the sensitivity, permitting a search for such particles with charges and energies beyond what was prev
Because the 14C calibration curves IntCal and SHCal are based on data from temperate latitudes, it remains unclear which curve is more suitable for archaeological and paleoenvironmental records from tropical South America. A review of climate dynamics reveals a significant influx of Northern Hemisphere air masses and moisture over a substantial part of the continent during the South American Summe
Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan con
Avhandlingen undersöker olika faktorer som påverkar livsvillkoren för unga svenskar med invandrarbakgrund. Genom att undersöka hur ungdomar föreställer sig sin framtid och vägen dit syftar studien till att ge insikt i hur ungdomar ser på sina livsmöjligheter. Avhandlingen diskuterar hur individer genom sina sociala nätverk (socialt kapital) och medverkan i olika kulturella aktiviteter (kulturellt The dissertation examines the determinants of life chances among young people with immigrant background in Sweden. The dissertation includes four research papers, each examining a specific research question on a determinant of life chances. The studies are based on datasets from two surveys: the Social Capital and Labour Market Integration survey, and a longitudinal study of ten schools in Malmö.S
Background and purpose — Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with or without OA risk factors. Patients and methods — 340 subjects from the Osteoarthritis Initiative, a
Planning and execution of large infrastructure projects benefit from detailed mapping of the subsurface through geophysical methods. However applying geophysical methods in an urban environment requires careful preparation to ensure success in areas where source of noise and present infrastructure may compromise the results. We present and discuss the results of a seismic investigation conducted i
Aim: This study determined the use of standardised procedures for infant noninvasive blood pressure (NIBP) measurements in the Nordic countries and aimed to identify factors included in the standardisation and interpretation of NIBP measurements in infants. Methods: A cross-sectional electronic questionnaire survey was sent to 84 physicians in all 23 university hospitals in Sweden, Norway, Denmark
Postpartum depression (PPD) är ett globalt folkhälsoproblem. Mödrar som migrerar till ett annat land har en ökad risk att drabbas av PPD. Före-komsten av PPD bland utlandsfödda mödrar beräknas vara så hög som 20 procent, vilket nästan är dubbelt så hög som bland inhemsk västerländsk befolkning. Asylsökande och flyktingar är särskilt sårbara grupper som löper en ännu högre risk att drabbas, speciel
We have measured the cross section and single-spin asymmetries from forward W±→μ±ν production in longitudinally polarized p+p collisions at s=510 GeV using the PHENIX detector at the Relativistic Heavy Ion Collider. The cross sections are consistent with previous measurements at this collision energy, while the most forward and backward longitudinal single spin asymmetries provide new insights int
Atherosclerosis is the main killer in the western world. Today’s clinical markers include the total level of cholesterol and high-/low-density lipoproteins, which often fails to accurately predict the disease. The relationship between the lipid exchange capacity and lipoprotein structure should explain the extent by which they release or accept lipid cargo and should relate to the risk for develop
Background and Purpose: It has been recognized that postischemic pharmacological interventions may delay the evolution of neuronal damage rather than provide long-lasting neuroprotection. Also, fever complicates recovery after stroke in humans. Here we report the effects of late postischemic treatment with hypothermia and an antipyretic/anti-inflammatory drug, dipyrone, on cell damage at 1 week an
