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This study investigated the rationale of boron neutron capture therapy (BNCT) for the treatment of Grade III and IV astrocytoma. The European Community joint research program on BNCT plans to use sulfhydryl boron hydride (BSH) in clinical trials. The work presented here, examines the performance of BSH in eight patients with Grade III and IV astrocytoma using a measurement technique which precisel
Genetically engineered mice have successfully been used to investigate molecular and cellular mechanisms associated with cell dysfunction following brain trauma. Such animals may also offer a possibility to investigate mechanisms involved in posttraumatic hemodynamic alterations. The objective of the study was to establish a mouse model in which important hemodynamic alterations following trauma c
Escherichia coli TolA is a cytoplasmic membrane protein required for outer membrane integrity and the translocation of F-specific filamentous (Ff) bacteriophage DNA. Both phage infection and membrane integrity depend on several TolA interactions, e.g. those of the TolA C-terminal domain (TolAIII). Membrane integrity involves interaction with two host proteins and phage translocation requires direc
The pine sawfly, Diprion jingyuanensis Xiao et Zhang, is a serious pest of Chinese pine (Pinus tabulaeformis Carr.) in the northern parts of China. The general biology of this recently described sawfly species is little known and in the present study we used a synthetic pheromone to monitor its flight period and to evaluate the possibility to use pheromone traps as a tool for estimating and predic
The major aim of our current work is to develop a deep understanding of biological effects of nanoparticles and how these effects are mediated by proteins that are adsorbed on the nanoparticles under different biological circumstances. Due to their small size, nanoparticles have distinct properties compared to the bulk form of the same materials, and these properties are rapidly revolutionizing ma
It has been suggested that autochthonous (internally produced) organic carbon and allochthonous (externally produced) organic carbon are utilized by phylogenetically different bacterioplankton. We examined the relationship between the source of organic matter and the structure and function of lake bacterial communities. Differences and seasonal changes in bacterial community composition in two lak
Irritable bowel syndrome has a negative impact on a person's quality of life, but only a few existing studies have been based on patients' own perceptions. This study therefore aimed to collect information on the view of female patients with irritable bowel syndrome regarding what constitutes a good quality of life for them and to create a healthcare model for these patients. For the study, 30 wom
This thesis explored the application of pre-trained transformer models in detecting suicidal ideation in social media posts. We leveraged social media data from platforms like Reddit and Twitter and applied a robust hyperparameter random search strategy to fine-tune and evaluate existing transformer models. Despite noise in the fine-tuning data, the models demonstrated high performance in identify
This thesis addresses the problem of horizontal incoherence between the first and second pillar of the European Union in its external relations. Horizontal coherence is an important concept for the European Union's legitimacy and strength. Internally, coherence is essential for the Union's democratic legitimacy, as democratic influx comes from the Council. Externally, to the extent incoher
Shared e-scooters are sometimes presented as a sustainable mobility option, but their environmental impact depends on their utilization. When utilization is low, idle e-scooters increase operational costs and decrease overall energy efficiency. This thesis explores whether neighborhood-level built environment and socio-demographic characteristics influence the usage efficiency of shared e-scooters
This master thesis investigates the legal foundations for training of artificial intelligence (AI) models using personal data, with an emphasis on compliance with the European Union’s General Data Protection Regulation (GDPR). The core issue addressed is the lack of clear legal basis for AI training processes that involve the collection and use of personal data (gathered directly or indirectly thr
Syftet med studien är att undersöka hur det fysiska och det digitala flödet för sterilhantering av instrument kombineras på ett sjukhus. Detta för att kunna utläsa hur dessa två flöden stödjer varandra mot riskförebyggande för att tillgodose behoven för ett framgångsrikt tjänstemöte.
Business & IT alignment (BIA) är ett komplext ämne som har studerats i över trettio år och handlar om hur IT och verksamheten ska integreras. För att en organisation ska ha möjlighet att prestera på hög nivå är integrering av IT och verksamheten vitalt. The Strategic Alignment Model är en modell utformad på 90-talet för att beskriva vilka komponenter som är viktiga att beakta för att lyckas in
Purpose – The purpose behind our study was to understand how individuals socially construct followership in a management consultancy. We did this through exploring the relations between consultants and their selected leaders, as well as through exploring how they related to the notion of followership. Literature review – We selected theory that was relevant with respect to our research question a
This thesis explores how early-stage startup founders use their professional networks to acquire equity investment from venture capitalists and business angels. Through qualitative interviews with founders across various industries, the research reveals essential networking practices that lead to successful fundraising efforts. The study highlights how building trust and credibility with network c
This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. Studies were eligible if they quantitatively assessed death anxiety or death acceptance using validated measures, or qualitatively explored attitudes toward death
