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A method for determination of N-methylsuccinimide (MSI) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in human urine and of MSI in human plasma was developed. MSI and 2-HMSI are metabolites of the widely used organic solvent N-methyl-2-pyrrolidone (NMP). MSI and 2-HMSI were purified from urine and plasma by C8 solid-phase extraction and analysed by gas chromatography-mass spectrometry in the negative
Objective: To clarify the relationship between symptoms, clinical signs and physiological abnormalities that were motivating the initiation of home mechanical ventilation in patients suffering from neuromuscular diseases. Methods: From The Swedish Home Mechanical Ventilation Register we identified 352 patients with neuromuscular diseases and we looked at circumstances ( acute vs elective) and clin
Lipoprotein(a) [Lp(a)], a strong independent cardiovascular risk factor, consists of the unique apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein particle. Apo(a) contains a widely differing number of the plasminogen-like kringle IV, a size polymorphism that is codominantly inherited. In addition to powerful genetic control, renal failure is known to influence the plasma Lp
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women(1-4). A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified(5-9). We previously reported a susceptibility locus (SLEB2) for Nordic multi-case
This master thesis is commissioned by the company Haldex Brake Products AB based in Landskrona. The company is acting on the road vehicle market. Amongst other products the company produces disc brakes for the heavy road vehicle industry. Disc brakes developed by Haldex, based on the sliding caliper principle, are during certain circumstances experiencing problems with malfunction of the brake due
The end of the Cold War altered the international landscape. New insecurities, vast humanitarian crises, extended normative frameworks, and increased funding incited established and new international NGOs to expand their engagement in peace processes. In Nepal a failed democratization process during the 1990s regressed into a decade-long internal armed conflict. Today Nepal is undergoing a transit
Existing immigration policy research often fails to recognise the analytical distinctions between two distinct, yet related, components of immigration policy: immigration control (IC), and immigrant integration. As a consequence research theorising the sources and outcomes of immigration policy either conflates these two components, or fails to address IC policy in its own right. Where IC policy i
Sustainability has become one of the key challenges in the fashion industry, which has been criticized for intense resource use, severe environmental impacts and wasteful business model. There have been a lot of new attempts and initiatives to promote sustainable fashion consumption. Collaborative consumption has been highlighted as one of the alternatives to conventional mass consumption. The ide
In Sweden, hypertension, is one of the most common reasons to attend primary care thus a Swedish public health problem of epic proportions. There is a general consensus about that effective antihypertensive treatment reduces the risk of developing cardiovascular diseases and premature death. Non-pharmacological treatment is advocated to be the basis of treatment. The caregiver is responsible for s
A proteoglycan is a protein with at least one glycosidic chain or glycosaminoglycan (GAG) covalently bound to it. Since a common linker between the core protein and the GAG chain has a xylose present, the biosynthesis of GAGs can be primed using xylosides containing hydrophobic aglycons providing that these xylosides are capable of penetrating the cell membrane. 2-naphthyl β-D-xylopyranoside prim
The association between obesity and psychological stress is ambiguous. The aim is to investigate the association between metabolic syndrome (MetS) and body mass index (BMI), respectively, with occupational stress among Japanese office workers. The study is a secondary analysis of the intervention group from a randomized controlled trial. There are 167 participants included in the analysis. Occupat
The geomagnetic field behavior in polar regions remains poorly understood and documented. Although a number of Late Holocene paleomagnetic secular variation (PSV) records exist from marginal settings of the Amerasian Basin in the Arctic Ocean, their age control often relies on a handful of radiocarbon dates to constrain ages over the past 4,200 years. Here we present well-dated Late Holocene PSV r
Non-medical prescription use of opioids (NMPUO) is a public health concern worldwide. Recently, tramadol misuse is increasing, but the systematic research of misuse of this specific opioid is limited. This study set out to assess the relationship between tramadol use and completion of treatment for substance use among adolescents and adults ≤ 25 years in an outpatient clinical setting. A retrospec
Visibility across supply chains has been a key concern for organisations for many years, but the tools and information systems to achieve real-time visibility have not been available until recently. In response to uncertainty and complexity, advanced information and communication technologies have been explored for supply chain visibility (SCV). However, managerial perspectives are largely absent
Background: Patients with oesophageal and gastric cancer face a poor prognosis and multiple symptoms and problems that negatively affect their quality of life. In view of the prognosis and extensive illness burden, an early palliative care approach is of importance.Aim: The overall aim of this thesis was to describe and compare symptoms, problems and care needs in relation to the initial treatment
Objective: To assess the feasibility and acceptability of HPV self-sampling in Arusha region, northern Tanzania, because the ability for women to self-collect HPV samples can help reduce the number of health facility visits and improve cervical cancer screening coverage rates. Methods: We conducted a facility- and community-based cross-sectional study among 350 women aged 25–55 years in Arumeru di
Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut
