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The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. In a bivariate analysis combining the nevus results with a recent mela

Water-, sanitation-, and hygiene-related diseases are killing many people each year in developing countries, including Rwanda, and children under the age of five are the most vulnerable. This research assessed human waste disposal practices, knowledge on diseases caused by contact with human faeces, and knowledge on causes and prevention of selected WASH-related diseases. One thousand one hundred

This paper aims to portray the increasingly complex normative structure of international climate change regime, which consists of the 1992 UN Framework Convention on Cimate Change, the 1997 Kyoto Protocol as well as other additional elements that playing a role, such as the practices of the Intergovernmental Panel on Climate Change and the Global Environmental Facility and procedures of these inst

This paper presents and discusses a new database on nominal and real effective exchange rates for an extensive range of European countries spanning 1870-2016. Indeed, with the exception of a few countries, such long run historical series have not been previously constructed. To gage the validity of these series, comparisons with the BIS and IMF indices are conducted. In addition to stretching furt

Background and purpose. Sensorimotor stroke (SMS) is often included among the lacunar syndromes, although the underlying cause of this stroke-subtype is less well documented. To this end we analysed 32 patients presenting with a sensorimotor syndrome. Methods. The study protocol included vascular risk factors, echocardiography, Doppler sonography of carotid arteries, CT scan and MRI of the brain.

The applications of femtosecond lasers to the diagnostics of combustion and flow field have recently attracted increasing interest. Many novel spectroscopic methods have been developed in obtaining non-intrusive measurements of temperature, velocity, and species concentrations with unprecedented possibilities. In this paper, several applications of femtosecond-laser-based incoherent techniques in

□ Total hip arthroplasty (THA) registers are established in several countries to collect data aiming to improve the results after THA. Monitoring of adverse outcomes after THA has focused mainly on revision surgery, but patientreported outcomes have also been investigated. □ Several surgery-related factors influencing the survival of the THA have been thoroughly investigated and have changed clini

We introduce new and simple algorithms for the calculation of the number of perfect matchings of complex weighted, undirected graphs with and without loops. Our compact formulas for the hafnian and loop hafnian of n × n complex matrices run in O(n32n/2) time, are embarrassingly parallelizable and, to the best of our knowledge, are the fastest exact algorithms to compute these quantities. Despite o

Label: Musica Rediviva MRCD 102

Based on the requirements for advanced treatment and resource recovery of nitrogen and phosphorus pollutants in wastewater, the coupled anammox and hydroxyapatite crystallization (anammox-HAP) process was studied with an aim of achieving high efficiency and low energy consumption during simultaneous nitrogen and phosphorus removal. In the long-term experiments and batch tests, the effects of subst

X-ray free-electron lasers (FELs), which amplify light emitted by a relativistic electron beam, are extending nonlinear optical techniques to shorter wavelengths, adding element specificity by exciting and probing electronic transitions from core levels. These techniques would benefit tremendously from having a stable FEL source, generating spectrally pure and wavelength-tunable pulses. We show th

The aim of this work is to develop a novel green solvent based sustainable process to refine lignin into low molecular weight (LMW) and high molecular weight (HMW) fractions. Lignin dispersity reduction were experimentally determined using four solvent mixtures, and benchmarked against eight pure solvents. Data outputs were used for modelling the integrated fractionation process. Dispersity reduct

This case study on the dark side of communication and place branding explores the Amazon corporation’s highly-publicized competitive search for a city to become their second headquarters (dubbed HQ2). In 2017 Amazon sent an open Request for Proposals (RFP) to cities in North America defining what constitutes an ‘ideal’ headquarters. In addition to offering capital and incentives, Amazon’s ideal ci

Innovation in retailing is under-investigated in academia and yet a highly relevant concern given the current changes in the retail landscape. Although retailing is often characterized by a dynamic and highly competitive environment, retail organi- zations are not often considered as ‘innovative,’ at least when compared with manufacturing industries, or when using exist- ing innovation frameworks

Considering the growth in urbanization, leading to an increase in impervious surfaces, and the changing climate, enhancing the intensity and frequency of rainfall events, existing urban drainage networks—separate or combined sewer systems—are presumed to face substantially elevated hydraulic loads, causing pluvial floods in urban areas. There are several ways to address these challenges. Cities ca

Construction of a genetic linkage map of the laboratory rat, Rattus norvegicus, establishes the rat as a genetic model. Allele sizes were reported for 432 simple sequence length polymorphisms (SSLPs) genotyped in 12 different substrains belonging to nine different inbred strains of rats. However, these nine strains represent only a fraction of the more than 140 inbred strains available. If allele