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PURPOSE: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.EXPERIMENTAL DESIGN: The efficacy of HDACi

While research indicates that indoor lighting, exposure to daylight, physical activity, and sleep interact to influence functioning, mood, and daily rhythm, strategies are needed to support behavioral changes among older adults who often spend more time at home after retirement. The objective was to design a web-based course to encourage behavior change related to light, activity, and sleep. GrounWhile research indicates that indoor lighting, exposure to daylight, physical activity, and sleep interact to influence functioning, mood, and daily rhythm, strategies are needed to support behavioral changes among older adults who often spend more time at home after retirement. The objective was to design a web-based course to encourage behavior change related to light, activity, and sleep. Groun

This article uses new quantitative data to systematically test established arguments concerning the origins of party strength in 11 West European countries between 1870 and 1939. Through time-series cross-sectional analyses and using a wide range of sources, I investigate the role of the development of parliamentarism, suffrage extension, civil society, and the adoption of proportional representat

En större mängd kvartsavslag och brända ben, upptäckta vid rekognosering (Norrbottens Museum) av hyggesberedda ytor norr om byn Sammakko, c. 40 km SO Gällivare, har tolkats att indikera ett kortvarigt använt boplatsområde. Platsen, liggande c. 100 meter norr Linaälven och i kanten av en nästan igenväxt göl, genomgick arkeologisk förundersökning sommaren 2019. Insamlat material av brända ben och trA large number of quartz fragments from knapping andburnt bone, discovered during reconnaissance (NorrbottensMuseum) of forest-cleared areas north of the villageSammakko, c. 40 km SE of Gällivare, have been interpretedto indicate a short-term used dwelling site. Th esite, located c. 100 meters north of the Linaälven Riverand at the edge of an almost overgrown pond, underwentarchaeological prelimin

BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the preferred treatment of peritoneal carcinomatosis (PC) of colorectal carcinoma. Patients with positive lymph node status have worse survival after CRS-HIPEC, which is probably due to higher rates of systemic failure. In this study, we analysed the effect of administration and timing of systemic chemot

Sammanställning av kursvärdering för JAPC01, ht 2018 1= stämmer inte alls; 5 stämmer helt. Svarande: 33 Kommentarerna återges ordagrant, avgränsade med semikolon. 1. Läraren/ lärarna var pedagogiska och kunde förklara innehållet på ett bra sätt: 4,03 Kom: Det var stundtals svårt att hänga med och lite överrumplande; Var inte här ofta nog för att ha en bra uppfattning, men intrycket jag fick var po

https://www.sol.lu.se/media/utbildning/dokument/kurser/JAPC01/20182/Sammanst_llningKursv_rderingJAPC01ht18.docx - 2026-05-28

Sites of Lobaria pulmonaria reported from the nemoral zone of the Swedish provinces Skåne and Blekinge since 1990 were revisited. At each locality, the habitat ecology and lichen viability were investigated. A substantial decline was noted, particularly in Skåne, as L. pulmonaria was found at only 24 sites, 22 of which were forests and two were wooded meadows. The commonest habitats for L. pulmona

The HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was condThe HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was cond

Molecular dynamic simulation of nanosized single-crystal copper beams loaded in tension at different strain rates until necking has been performed for two different crystallographic orientations, the [100]- and the [110]-orientations. The molecular dynamics freeware code LAMMPS was employed for the simulations. It was found that, at low enough strain rates, single necking was obtained for both cry

The implementation of market solutions has been widely attempted in many different parts of the public sector. This chapter concerns a groundbreaking social reform, which introduced personal assistants for ‘functionally impaired’ people. It was a far-reaching and liberating reform aimed at making disabled people part of society. It replaced collective institutional care with individual choice, in

Popular Abstract in Swedish Den globala landbaserade kolcykeln reglerar mängden växthusgaser i atmosfären. För närvarande tas varje år 25-30% av våra utsläpp upp av de landbaserade ekosystemen vilket är en viktig ekosystemtjänst som kanske inte kommer att bestå i längden. Upptagskapaciteten av både hav och landbaserade ekosystem tenderar att försvagas av global uppvärmning. Detta leder till att enThe global terrestrial carbon cycle plays a pivotal role in regulating the atmospheric composition of greenhouse gases. Currently it is responsible for removing 25-30% of our emissions every year, an important ecosystem service that may not persist in the long term. Global warming tends to decrease the CO2 sink capacity of the world’s oceans and ecosystems leading to a larger fraction of our emiss

Irritable bowel syndrome has a negative impact on a person's quality of life, but only a few existing studies have been based on patients' own perceptions. This study therefore aimed to collect information on the view of female patients with irritable bowel syndrome regarding what constitutes a good quality of life for them and to create a healthcare model for these patients. For the study, 30 wom

BACKGROUND AND AIMS: Developing care for older people in the last phase of life requires knowledge about the type and extent of care and factors associated with the place of death. The aim of this study was to examine age, living conditions, dependency, care and service among old people during their last year of life, but also their place of death and factors predicting it. METHODS: The sample (n=

Objectives To determine whether three-dimensional (3D) ultrasound including power Doppler examination of the cervix is useful for predicting time to spontaneous onset of labor or time to delivery in prolonged pregnancy. Methods A prospective study was conducted in 60 women who went into spontaneous labor. All underwent transvaginal 3D power Doppler ultrasound examination of the cervix immediately

Popular Abstract in Swedish Den vanligaste lokalisationen för bråck eller aneurysm på stora kroppspulsåderns (AAA) är i buken nedanför njurpulsådrorna. Mellan 3-6% av befolkningen över 65 års har detta och det är vanligare hos män jämfört med kvinnor (3:1). Majoriteten av bråcken är asymptomatiska och upptäcks som ett bifynd isamband med undersökning för mag eller ryggbesvär. Ca ¼ av bråcken debutAIM: The aim was to evaluate the results of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAA) in terms of intra-AAA pressure and clinical outcomes. METHODS AND RESULTS: 0.014-inch guide-wire-mounted tip-pressure sensors were used for direct intra-aneurysm sac pressure measurement (DISP) through translumbar puncture of the AAA. Mean Pressure Index was calculated (MPI) as the p

Popular Abstract in Swedish Strålbensfrakturer i armbågsleden I denna avhandling har jag försökt kartlägga hur det går för individer som drabbats av ett benbrott i anslutning till armbågen. I underarmen finns två ben, strålbenet och armbågsbenet. Strålbenets övre del ledar dels mot överarmsbenet men också mot armbågsbenet. När en person ramlar med utsträckt arm finns det risk att det uppstår ett All elbow fractures between 1969 – 1979 (n=2965) registered at the radiographic archives at the Malmö University Hospital, where all radiographs are saved since a century, were evaluated. Fractures of the radial head and neck were classified according to the by Broberg and Morrey modified Mason classification. A Mason type I fracture is a less than 2 mm displaced fracture of the radial head or nec

Today most companies have online sales channels. Most commonly have companies started offline and then later expanded online while others have started their business online through, for example, web shops. Even though we today are living in a high technology society, the existence of an offline sales channel is still needed. But what is the exact definition of a sales channel really? In today’s